SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dkj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		7 / 8 PHE A  17
GLU A  45
TRP A  46
ASP A 113
ILE A 114
PRO A 134
LEU A 157
 SAH  A 501 (-4.8A)
SAH  A 501 (-3.0A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.7A)
SAH  A 501 (-4.3A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
 0.59A 1hmyA-4dkjA:
29.5		 1hmyA-4dkjA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		3 / 3 PRO A 258
ASP A 223
ASP A 263
 None
 0.74A 1sqfA-4dkjA:
7.1		 1sqfA-4dkjA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 7 TYR A 131
LEU A 234
TYR A 210
ILE A 128
 None
 1.08A 1tuvA-4dkjA:
undetectable		 1tuvA-4dkjA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		3 / 3 ARG A 230
SER A  53
TYR A  54
 None
 0.52A 1x70A-4dkjA:
undetectable		 1x70A-4dkjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		6 / 12 PHE A  17
GLY A  19
GLY A  21
ILE A 114
PRO A 134
LEU A 157
 SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
SAH  A 501 (-4.3A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
 1.08A 2hmyB-4dkjA:
29.0		 2hmyB-4dkjA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		7 / 12 PHE A  17
GLY A  19
TRP A  46
ASP A 113
ILE A 114
PRO A 134
LEU A 157
 SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.7A)
SAH  A 501 (-4.3A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
 0.72A 2hmyB-4dkjA:
29.0		 2hmyB-4dkjA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		3 / 3 MET A 177
VAL A 391
GLU A 242
 None
 0.84A 2x9gA-4dkjA:
1.6		 2x9gA-4dkjA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 12 PHE A  17
GLY A  19
PRO A 134
LEU A 157
ASN A 374
 SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-4.3A)
 0.66A 3av6A-4dkjA:
14.3		 3av6A-4dkjA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 12 PHE A  17
GLY A  21
PRO A 134
LEU A 157
ASN A 374
 SAH  A 501 (-4.8A)
SAH  A 501 (-4.0A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-4.3A)
 0.96A 3av6A-4dkjA:
14.3		 3av6A-4dkjA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 4 GLU A 242
GLY A 245
THR A 244
GLU A 389
 None
 1.15A 3e9xA-4dkjA:
undetectable		 3e9xA-4dkjA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		6 / 12 PHE A  17
GLY A  21
ILE A 114
PRO A 134
LEU A 157
ASN A 374
 SAH  A 501 (-4.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-4.3A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-4.3A)
 1.01A 3eeoA-4dkjA:
33.6		 3eeoA-4dkjA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		7 / 12 PHE A  17
TRP A  46
ASP A 113
ILE A 114
PRO A 134
LEU A 157
ASN A 374
 SAH  A 501 (-4.8A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.7A)
SAH  A 501 (-4.3A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-4.3A)
 0.72A 3eeoA-4dkjA:
33.6		 3eeoA-4dkjA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		3 / 3 TYR A 210
TYR A 131
ILE A 161
 None
 0.80A 3eteA-4dkjA:
3.3
3eteB-4dkjA:
3.1		 3eteA-4dkjA:
20.97
3eteB-4dkjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 12 ASN A 352
ASP A 350
VAL A 378
SER A  59
ILE A  57
 None
 1.14A 3k13A-4dkjA:
undetectable		 3k13A-4dkjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 12 ASN A 352
ASP A 350
VAL A 378
SER A  59
ILE A  57
 None
 1.16A 3k13B-4dkjA:
undetectable		 3k13B-4dkjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 12 ASN A 352
ASP A 350
VAL A 378
SER A  59
ILE A  57
 None
 1.15A 3k13C-4dkjA:
undetectable		 3k13C-4dkjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 5 PHE A  24
ILE A 376
MET A  43
ASN A 109
 None
 1.35A 3octA-4dkjA:
undetectable		 3octA-4dkjA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 5 GLY A  21
ILE A  20
VAL A 378
SER A 375
 SAH  A 501 (-4.0A)
SAH  A 501 (-4.4A)
None
SAH  A 501 (-3.0A)
 1.08A 4d33A-4dkjA:
undetectable		 4d33A-4dkjA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 5 GLY A  21
ILE A  20
VAL A 378
SER A 375
 SAH  A 501 (-4.0A)
SAH  A 501 (-4.4A)
None
SAH  A 501 (-3.0A)
 1.08A 4d33B-4dkjA:
undetectable		 4d33B-4dkjA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 6 GLY A  21
ILE A  20
VAL A 378
SER A 375
 SAH  A 501 (-4.0A)
SAH  A 501 (-4.4A)
None
SAH  A 501 (-3.0A)
 1.07A 4d39B-4dkjA:
undetectable		 4d39B-4dkjA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 6 ASN A 275
TYR A 299
TYR A 279
LEU A 296
 None
 1.46A 4f8yA-4dkjA:
3.2
4f8yB-4dkjA:
4.0		 4f8yA-4dkjA:
19.52
4f8yB-4dkjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 5 LEU A 318
ARG A 228
ILE A 291
ASN A 303
 None
 1.37A 4i00A-4dkjA:
undetectable		 4i00A-4dkjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 5 GLY A  19
TYR A 131
SER A 132
GLU A  45
 SAH  A 501 (-3.4A)
None
SAH  A 501 (-2.7A)
SAH  A 501 (-3.0A)
 1.38A 4xueA-4dkjA:
6.9		 4xueA-4dkjA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 12 TYR A 307
ILE A 327
LEU A 338
GLY A 315
ILE A 261
 None
 0.97A 5d4uD-4dkjA:
undetectable		 5d4uD-4dkjA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 12 ASP A 113
PRO A 134
PHE A  17
GLY A  19
GLU A  45
 SAH  A 501 (-3.7A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.0A)
 0.60A 5hfjA-4dkjA:
undetectable		 5hfjA-4dkjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 12 ASP A 113
PRO A 134
PHE A  17
GLY A  19
GLU A  45
 SAH  A 501 (-3.7A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.0A)
 0.55A 5hfjD-4dkjA:
undetectable		 5hfjD-4dkjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 12 ASP A 113
PRO A 134
PHE A  17
GLY A  19
GLU A  45
 SAH  A 501 (-3.7A)
SAH  A 501 ( 4.4A)
SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.0A)
 0.68A 5hfjF-4dkjA:
4.7		 5hfjF-4dkjA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		5 / 11 PHE A  17
GLY A  19
GLU A  45
ASP A 113
PRO A 134
 SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.0A)
SAH  A 501 (-3.7A)
SAH  A 501 ( 4.4A)
 0.45A 5hjiA-4dkjA:
5.2		 5hjiA-4dkjA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 5 ILE A  51
PHE A  62
SER A  99
ALA A 104
 None
 1.07A 5msdA-4dkjA:
2.9		 5msdA-4dkjA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 7 THR A 387
ILE A 236
TYR A 215
PHE A 248
 None
 0.92A 5zsfA-4dkjA:
undetectable
5zsfB-4dkjA:
undetectable		 5zsfA-4dkjA:
10.92
5zsfB-4dkjA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		7 / 12 PHE A  17
GLY A  19
TRP A  46
ASP A 113
ILE A 114
ASN A 374
SER A 375
 SAH  A 501 (-4.8A)
SAH  A 501 (-3.4A)
SAH  A 501 (-4.0A)
SAH  A 501 (-3.7A)
SAH  A 501 (-4.3A)
SAH  A 501 (-4.3A)
SAH  A 501 (-3.0A)
 0.61A 6mhtA-4dkjA:
31.7		 6mhtA-4dkjA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 6 ASP A 267
TYR A 271
GLU A 342
CYH A 225
 None
 1.36A 6mn5A-4dkjA:
undetectable		 6mn5A-4dkjA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4dkj CYTOSINE-SPECIFIC
METHYLTRANSFERASE
(Mycoplasma
penetrans) 		4 / 6 ASP A 267
TYR A 271
GLU A 342
CYH A 225
 None
 1.40A 6mn5C-4dkjA:
undetectable		 6mn5C-4dkjA:
10.53