SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		5 / 12 ILE A 242
ALA A 240
PHE A 237
THR A 294
ILE A 298
 None
None
None
CLR  A 614 ( 4.0A)
CLR  A 614 ( 4.1A)
 1.09A 1dyiA-4dklA:
undetectable		 1dyiA-4dklA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		4 / 5 LEU A 339
GLU A 341
ALA A 337
LEU A 335
 None
 1.10A 1eta1-4dklA:
undetectable		 1eta1-4dklA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		4 / 5 LEU A 339
GLU A 341
ALA A 337
LEU A 335
 None
 1.14A 1eta2-4dklA:
undetectable		 1eta2-4dklA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		4 / 6 LEU A 339
GLU A 341
ALA A 337
LEU A 335
 None
 1.09A 1etb1-4dklA:
undetectable		 1etb1-4dklA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_2_T442129_1
(TRANSTHYRETIN)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		4 / 6 LEU A 339
GLU A 341
ALA A 337
LEU A 335
 None
 1.13A 1etb2-4dklA:
undetectable		 1etb2-4dklA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		5 / 12 ILE A 242
ALA A 240
PHE A 237
THR A 294
ILE A 298
 None
None
None
CLR  A 614 ( 4.0A)
CLR  A 614 ( 4.1A)
 1.06A 1tdrA-4dklA:
undetectable		 1tdrA-4dklA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		5 / 12 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 0.99A 2aclA-4dklA:
undetectable
2aclE-4dklA:
undetectable		 2aclA-4dklA:
19.01
2aclE-4dklA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		4 / 8 THR A1034
TYR A1025
ILE A1017
SER A1036
 None
 1.08A 2xytH-4dklA:
undetectable		 2xytH-4dklA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		3 / 3 LEU A  74
TRP A 318
TYR A 326
 None
None
BF0  A 601 (-3.8A)
 0.78A 3aicA-4dklA:
undetectable		 3aicA-4dklA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		3 / 3 LEU A  74
TRP A 318
TYR A 326
 None
None
BF0  A 601 (-3.8A)
 0.79A 3aicB-4dklA:
undetectable		 3aicB-4dklA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		3 / 3 LEU A  74
TRP A 318
TYR A 326
 None
None
BF0  A 601 (-3.8A)
 0.81A 3aicE-4dklA:
undetectable		 3aicE-4dklA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		3 / 3 LEU A  74
TRP A 318
TYR A 326
 None
None
BF0  A 601 (-3.8A)
 0.84A 3aicF-4dklA:
undetectable		 3aicF-4dklA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		3 / 3 LEU A  74
TRP A 318
TYR A 326
 None
None
BF0  A 601 (-3.8A)
 0.79A 3aicG-4dklA:
undetectable		 3aicG-4dklA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		3 / 3 LEU A  74
TRP A 318
TYR A 326
 None
None
BF0  A 601 (-3.8A)
 0.78A 3aicH-4dklA:
undetectable		 3aicH-4dklA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		5 / 12 MET A1102
PHE A1114
ALA A1112
PHE A1153
GLY A1077
 None
 1.49A 3aobC-4dklA:
undetectable		 3aobC-4dklA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		5 / 11 ALA A1129
PHE A1153
LEU A1133
ALA A1130
ILE A1078
 None
 1.01A 3fc6A-4dklA:
undetectable		 3fc6A-4dklA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		4 / 7 VAL A  78
LEU A 335
LEU A  88
ILE A  77
 None
 0.74A 3gp0A-4dklA:
undetectable		 3gp0A-4dklA:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		5 / 12 ASP A 147
TYR A 148
ILE A 155
TRP A 293
TYR A 326
 BF0  A 601 (-3.2A)
BF0  A 601 (-4.0A)
None
BF0  A 601 (-4.8A)
BF0  A 601 (-3.8A)
 0.78A 3rzeA-4dklA:
28.8		 3rzeA-4dklA:
53.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		5 / 12 ILE A 242
ALA A 240
PHE A 237
THR A 294
ILE A 298
 None
None
None
CLR  A 614 ( 4.0A)
CLR  A 614 ( 4.1A)
 1.12A 4x5hA-4dklA:
undetectable		 4x5hA-4dklA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		5 / 12 ILE A 242
ALA A 240
PHE A 237
THR A 294
ILE A 298
 None
None
None
CLR  A 614 ( 4.0A)
CLR  A 614 ( 4.1A)
 1.10A 4x5jA-4dklA:
undetectable		 4x5jA-4dklA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		4 / 8 ASN A1144
ARG A1145
ARG A1148
THR A1021
 SO4  A 612 (-4.0A)
None
None
None
 1.20A 5db5A-4dklA:
undetectable
5db5B-4dklA:
undetectable		 5db5A-4dklA:
20.25
5db5B-4dklA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		5 / 12 ILE A 242
ALA A 240
PHE A 237
THR A 294
ILE A 298
 None
None
None
CLR  A 614 ( 4.0A)
CLR  A 614 ( 4.1A)
 1.08A 5e8qA-4dklA:
undetectable		 5e8qA-4dklA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		5 / 12 ILE A 242
ALA A 240
PHE A 237
THR A 294
ILE A 298
 None
None
None
CLR  A 614 ( 4.0A)
CLR  A 614 ( 4.1A)
 1.13A 5e8qB-4dklA:
undetectable		 5e8qB-4dklA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		4 / 7 THR A1026
TYR A1018
GLU A1011
HIS A1031
 None
 0.99A 5ecnA-4dklA:
undetectable		 5ecnA-4dklA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Escherichia
virus
T4;
Mus
musculus) 		5 / 12 MET A1102
ALA A1074
VAL A1149
LEU A1121
VAL A1087
 None
 1.23A 5tudD-4dklA:
25.1		 5tudD-4dklA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		5 / 12 ILE A 242
ALA A 240
PHE A 237
THR A 294
ILE A 298
 None
None
None
CLR  A 614 ( 4.0A)
CLR  A 614 ( 4.1A)
 1.15A 5ujxB-4dklA:
undetectable		 5ujxB-4dklA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4dkl MU-TYPE OPIOID
RECEPTOR, LYSOZYME
CHIMERA
(Mus
musculus;
Escherichia
virus
T4) 		4 / 5 ASP A 147
ILE A 155
PHE A 289
TYR A 326
 BF0  A 601 (-3.2A)
None
None
BF0  A 601 (-3.8A)
 0.54A 6a93B-4dklA:
28.6		 6a93B-4dklA:
25.88