SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		4 / 8 GLY A  25
GLY A  26
TYR A  61
VAL A 199
 None
None
CR2  A  60 ( 3.5A)
None
 0.91A 1dbbH-4dknA:
undetectable
1dbbL-4dknA:
undetectable		 1dbbH-4dknA:
20.58
1dbbL-4dknA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		4 / 7 TYR A 175
HIS A   7
TYR A  61
GLY A  28
 None
None
CR2  A  60 ( 3.5A)
None
 1.33A 1mxgA-4dknA:
undetectable		 1mxgA-4dknA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		4 / 6 LEU A 208
SER A 141
PHE A 155
GLU A 210
 CR2  A  60 ( 4.9A)
CR2  A  60 ( 4.0A)
CR2  A  60 ( 4.0A)
CR2  A  60 ( 3.0A)
 1.14A 2vn1B-4dknA:
undetectable		 2vn1B-4dknA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		5 / 12 THR A 207
THR A  37
HIS A   7
LEU A  35
TYR A  64
 None
 1.35A 3gwxB-4dknA:
undetectable		 3gwxB-4dknA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		4 / 7 ILE A   9
LYS A  43
PHE A  20
GLY A  13
 None
 1.25A 3sj0X-4dknA:
undetectable		 3sj0X-4dknA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		5 / 12 ASP A 153
ALA A  85
TYR A  84
TYR A 175
SER A 173
 None
 1.30A 4mm4A-4dknA:
undetectable		 4mm4A-4dknA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		5 / 12 ASP A 153
ALA A  85
TYR A  84
TYR A 175
SER A 173
 None
 1.29A 4mm4B-4dknA:
undetectable		 4mm4B-4dknA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		5 / 11 ASP A 153
ALA A  85
TYR A  84
TYR A 175
SER A 173
 None
 1.29A 4mm9A-4dknA:
undetectable		 4mm9A-4dknA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		5 / 12 PHE A 102
ILE A   9
LEU A  57
LEU A  98
LEU A 117
 None
None
CR2  A  60 ( 4.4A)
None
None
 1.32A 4qynB-4dknA:
undetectable		 4qynB-4dknA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		4 / 5 SER A  77
TYR A  84
GLY A  83
TYR A 106
 None
 1.50A 5yodH-4dknA:
undetectable		 5yodH-4dknA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 4dkn AMPHIOXUS GREEN
FLUORESCENT PROTEIN,
GFPA1
(Branchiostoma
floridae) 		5 / 12 GLY A  26
HIS A 110
TYR A 104
PRO A   4
GLY A  28
 None
None
CR2  A  60 ( 4.5A)
None
None
 1.14A 6gngA-4dknA:
undetectable		 6gngA-4dknA:
16.20