SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 4dkw LARGE TERMINASE
PROTEIN
(Salmonella
virus
P22) 		4 / 7 VAL A 413
ILE A 417
GLU A 441
LEU A 344
 None
 0.91A 1j96B-4dkwA:
undetectable		 1j96B-4dkwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 4dkw LARGE TERMINASE
PROTEIN
(Salmonella
virus
P22) 		3 / 3 CYH A 435
PHE A 438
PHE A 439
 None
 0.71A 3cr5X-4dkwA:
undetectable		 3cr5X-4dkwA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 4dkw LARGE TERMINASE
PROTEIN
(Salmonella
virus
P22) 		5 / 9 LEU A 333
ALA A 463
ASP A 321
VAL A 347
ILE A 331
 None
None
MG  A 501 (-2.6A)
None
None
 0.96A 3wsjA-4dkwA:
undetectable		 3wsjA-4dkwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 4dkw LARGE TERMINASE
PROTEIN
(Salmonella
virus
P22) 		4 / 8 GLU A 419
PRO A 407
GLY A 410
ASP A 408
 None
 0.97A 5kgpA-4dkwA:
undetectable		 5kgpA-4dkwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 4dkw LARGE TERMINASE
PROTEIN
(Salmonella
virus
P22) 		4 / 8 GLU A 419
PRO A 407
GLY A 410
ASP A 408
 None
 0.96A 5kgpB-4dkwA:
undetectable		 5kgpB-4dkwA:
19.11