SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dlk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 7 THR A 251
GLY A 290
HIS A 292
THR A 280
 THR  A 251 ( 0.8A)
GLY  A 290 ( 0.0A)
HIS  A 292 ( 1.0A)
THR  A 280 ( 0.8A)
 0.88A 1gtnF-4dlkA:
undetectable
1gtnG-4dlkA:
undetectable		 1gtnF-4dlkA:
13.35
1gtnG-4dlkA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 7 THR A 251
GLY A 290
HIS A 292
THR A 280
 THR  A 251 ( 0.8A)
GLY  A 290 ( 0.0A)
HIS  A 292 ( 1.0A)
THR  A 280 ( 0.8A)
 0.95A 1gtnJ-4dlkA:
undetectable
1gtnK-4dlkA:
undetectable		 1gtnJ-4dlkA:
13.35
1gtnK-4dlkA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 6 HIS A 274
ILE A 194
LYS A 240
ALA A 243
 HIS  A 274 (-1.0A)
ILE  A 194 ( 0.7A)
LYS  A 240 ( 0.0A)
ALA  A 243 ( 0.0A)
 0.98A 1hk1A-4dlkA:
undetectable		 1hk1A-4dlkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 5 ILE A 266
LEU A 246
ALA A 113
GLU A 110
 ILE  A 266 ( 0.7A)
LEU  A 246 ( 0.6A)
ALA  A 113 ( 0.0A)
GLU  A 110 ( 0.6A)
 1.29A 1xvaA-4dlkA:
2.8
1xvaB-4dlkA:
2.6		 1xvaA-4dlkA:
20.90
1xvaB-4dlkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 8 GLY A  17
ASN A  42
SER A  43
GLN A  47
 GLY  A  17 ( 0.0A)
ASN  A  42 ( 0.6A)
SER  A  43 ( 0.0A)
GLN  A  47 (-0.6A)
 0.93A 2a8tB-4dlkA:
undetectable		 2a8tB-4dlkA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 7 ALA A 283
ASP A 282
GLY A 277
ILE A 194
 ALA  A 283 ( 0.0A)
ASP  A 282 ( 0.6A)
GLY  A 277 ( 0.0A)
ILE  A 194 ( 0.7A)
 0.84A 2fxdB-4dlkA:
undetectable		 2fxdB-4dlkA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 8 ALA A  24
ALA A  27
ILE A  13
THR A  74
 ALA  A  24 ( 0.0A)
ALA  A  27 ( 0.0A)
ILE  A  13 ( 0.7A)
THR  A  74 ( 0.8A)
 0.74A 3dtuC-4dlkA:
undetectable
3dtuD-4dlkA:
undetectable		 3dtuC-4dlkA:
19.18
3dtuD-4dlkA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		3 / 3 ILE A 137
VAL A 167
ARG A 171
 ILE  A 137 ( 0.6A)
VAL  A 167 ( 0.6A)
ARG  A 171 ( 0.6A)
 0.76A 3p73A-4dlkA:
1.6		 3p73A-4dlkA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		3 / 3 GLN A 158
GLU A 182
LYS A 147
 GLN  A 158 (-0.6A)
GLU  A 182 (-0.6A)
LYS  A 147 (-0.0A)
 1.18A 3su9A-4dlkA:
undetectable		 3su9A-4dlkA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 5 ARG A 107
HIS A 274
ALA A 270
GLU A 268
 ARG  A 107 (-0.6A)
HIS  A 274 (-1.0A)
ALA  A 270 ( 0.0A)
GLU  A 268 (-0.6A)
 1.41A 5a06C-4dlkA:
undetectable
5a06D-4dlkA:
undetectable		 5a06C-4dlkA:
21.81
5a06D-4dlkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 4 ARG A 107
HIS A 274
ALA A 270
GLU A 268
 ARG  A 107 (-0.6A)
HIS  A 274 (-1.0A)
ALA  A 270 ( 0.0A)
GLU  A 268 (-0.6A)
 1.34A 5a06A-4dlkA:
undetectable
5a06F-4dlkA:
1.2		 5a06A-4dlkA:
21.81
5a06F-4dlkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 7 HIS A 319
ILE A 320
VAL A 323
ARG A 325
 HIS  A 319 ( 1.0A)
ILE  A 320 ( 0.4A)
VAL  A 323 ( 0.6A)
ARG  A 325 ( 0.6A)
 1.16A 5kkzK-4dlkA:
undetectable
5kkzQ-4dlkA:
undetectable		 5kkzK-4dlkA:
21.21
5kkzQ-4dlkA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		3 / 3 LEU A 133
VAL A 167
ASP A 168
 LEU  A 133 ( 0.6A)
VAL  A 167 ( 0.6A)
ASP  A 168 ( 0.6A)
 0.64A 5x23A-4dlkA:
undetectable		 5x23A-4dlkA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4dlk PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT
(Bacillus
anthracis) 		4 / 8 PRO A 207
LYS A 204
THR A 286
TYR A 279
 PRO  A 207 ( 1.1A)
LYS  A 204 ( 0.0A)
THR  A 286 ( 0.8A)
TYR  A 279 ( 1.3A)
 1.36A 5x2sI-4dlkA:
undetectable
5x2sJ-4dlkA:
undetectable
5x2sK-4dlkA:
undetectable		 5x2sI-4dlkA:
17.77
5x2sJ-4dlkA:
19.82
5x2sK-4dlkA:
17.77