SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dll'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		4 / 8 LEU A 246
PRO A  45
VAL A 155
GLY A 156
 None
 0.95A 1hrkA-4dllA:
2.2		 1hrkA-4dllA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		4 / 8 LEU A 246
PRO A  45
VAL A 155
GLY A 156
 None
 0.94A 1hrkB-4dllA:
2.4		 1hrkB-4dllA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		5 / 11 LEU A 105
ALA A 144
VAL A 104
LEU A  37
HIS A 192
 None
 1.17A 1kt6A-4dllA:
undetectable		 1kt6A-4dllA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		5 / 11 LEU A 105
ALA A 144
VAL A 104
LEU A  37
HIS A 192
 None
 1.17A 1kt7A-4dllA:
undetectable		 1kt7A-4dllA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		4 / 4 GLY A 193
GLY A 167
GLY A 190
GLY A 195
 None
 0.57A 3bogC-4dllA:
undetectable		 3bogC-4dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		4 / 4 GLY A 193
GLY A 167
GLY A 190
GLY A 195
 None
 0.54A 3bogD-4dllA:
undetectable		 3bogD-4dllA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		5 / 12 LEU A 288
LEU A 309
ILE A 208
GLY A 211
ALA A 212
 None
 0.99A 3n8zB-4dllA:
undetectable		 3n8zB-4dllA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		5 / 12 ALA A 260
GLN A 306
ARG A 250
HIS A 247
ASP A 305
 None
 1.45A 3njzA-4dllA:
undetectable		 3njzA-4dllA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		4 / 6 ALA A 239
ILE A 234
LEU A 244
ALA A 212
 None
 0.89A 3r9sC-4dllA:
undetectable		 3r9sC-4dllA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		5 / 12 ILE A 164
LEU A  37
PHE A 183
ILE A  34
LEU A  57
 None
 1.20A 3w67C-4dllA:
undetectable		 3w67C-4dllA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		4 / 6 PHE A 106
ALA A 111
ALA A 140
LEU A 138
 None
 1.00A 4dtzA-4dllA:
undetectable		 4dtzA-4dllA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_A_DM2A1106_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		5 / 11 PHE A  36
PHE A 183
LEU A 179
THR A 148
ALA A 166
 None
 1.36A 4dx7A-4dllA:
undetectable		 4dx7A-4dllA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		4 / 5 GLY A 236
ASP A 240
GLU A 232
VAL A 252
 None
 0.93A 4nkvD-4dllA:
undetectable		 4nkvD-4dllA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE
(Polaromonas
sp.
JS666) 		4 / 4 LEU A 119
ILE A  90
PRO A 178
LEU A 180
 None
 0.97A 5eb3A-4dllA:
4.9		 5eb3A-4dllA:
20.81