SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dlo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		5 / 9 ILE A 741
VAL A 790
GLY A 763
ILE A 706
ILE A 718
 None
 0.96A 1hshB-4dloA:
undetectable		 1hshB-4dloA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		4 / 7 LEU A 762
ILE A 792
ALA A 764
ILE A 805
 None
 0.99A 1oniB-4dloA:
undetectable
1oniC-4dloA:
undetectable		 1oniB-4dloA:
21.67
1oniC-4dloA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		4 / 6 THR A 606
THR A 601
ASN A 625
ASP A 628
 None
None
NAG  A 904 (-1.6A)
None
 1.28A 2okcA-4dloA:
undetectable		 2okcA-4dloA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_B_VDYB6178_1
(VITAMIN D
HYDROXYLASE)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		5 / 12 THR A 699
ASN A 769
ILE A 678
VAL A 626
LEU A 623
 None
 1.44A 3a51B-4dloA:
undetectable		 3a51B-4dloA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		4 / 8 VAL A 642
PHE A 681
HIS A 683
VAL A 761
 None
 1.10A 3fhxB-4dloA:
undetectable		 3fhxB-4dloA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		3 / 3 HIS A 683
PHE A 645
PHE A 646
 None
 0.54A 3lk0D-4dloA:
undetectable		 3lk0D-4dloA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		5 / 12 ILE A 636
VAL A 598
ILE A 622
ILE A 684
ALA A 633
 None
 1.24A 3ohtA-4dloA:
undetectable
3ohtB-4dloA:
undetectable		 3ohtA-4dloA:
20.22
3ohtB-4dloA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		5 / 12 PHE A 746
LEU A 709
PHE A 720
ALA A 764
SER A 705
 None
 1.13A 3tbgD-4dloA:
undetectable		 3tbgD-4dloA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		5 / 11 LEU A 807
ILE A 805
ARG A 855
LEU A 770
ILE A 783
 None
 1.20A 4dm8A-4dloA:
undetectable		 4dm8A-4dloA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		4 / 8 LYS A 850
LEU A 852
GLU A 806
THR A 844
 None
 0.65A 4ik6B-4dloA:
undetectable		 4ik6B-4dloA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		4 / 6 VAL A 739
LEU A 803
LEU A 762
PHE A 646
 None
 1.12A 4o1zA-4dloA:
0.6		 4o1zA-4dloA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		4 / 7 ASN A 657
GLU A 656
GLU A 655
GLU A 659
 None
 1.27A 4r87I-4dloA:
undetectable		 4r87I-4dloA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		3 / 3 TRP A 834
ILE A 672
SER A 671
 None
 0.89A 5gqbA-4dloA:
undetectable		 5gqbA-4dloA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		4 / 8 ASP A 604
TYR A 572
SER A 650
ASN A 651
 None
 1.01A 5l1fA-4dloA:
undetectable
5l1fB-4dloA:
undetectable		 5l1fA-4dloA:
20.45
5l1fB-4dloA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		3 / 3 ALA A 811
GLN A 865
THR A 814
 None
 0.66A 5n0oA-4dloA:
undetectable		 5n0oA-4dloA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		5 / 12 VAL A 620
PHE A 630
ILE A 684
VAL A 685
VAL A 677
 None
 1.10A 6ap6A-4dloA:
undetectable		 6ap6A-4dloA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		5 / 12 VAL A 620
PHE A 630
ILE A 684
VAL A 685
VAL A 677
 None
 1.10A 6ap6B-4dloA:
undetectable		 6ap6B-4dloA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3
(Homo
sapiens) 		5 / 12 THR A 627
THR A 599
HIS A 683
VAL A 761
GLY A 688
 None
 1.31A 6gngB-4dloA:
undetectable		 6gngB-4dloA:
19.78