SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dlq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		5 / 10 LEU A 651
VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 1.41A 1sv5A-4dlqA:
0.5		 1sv5A-4dlqA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		4 / 6 LEU A 580
GLU A 556
ALA A 551
THR A 612
 None
 0.82A 2roxB-4dlqA:
undetectable		 2roxB-4dlqA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		4 / 8 HIS A 646
ASP A 582
LEU A 581
ASP A 653
 None
 1.19A 3n2oC-4dlqA:
6.2
3n2oD-4dlqA:
7.1		 3n2oC-4dlqA:
21.90
3n2oD-4dlqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		3 / 3 PHE A 697
SER A 703
SER A 705
 None
 0.99A 3ufgB-4dlqA:
undetectable		 3ufgB-4dlqA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		4 / 8 VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 0.95A 3v81C-4dlqA:
undetectable		 3v81C-4dlqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		4 / 8 VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 0.98A 4pwdC-4dlqA:
undetectable		 4pwdC-4dlqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		4 / 8 VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 1.12A 4q0bA-4dlqA:
undetectable		 4q0bA-4dlqA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		5 / 10 LEU A 651
VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 1.50A 6bsgA-4dlqA:
undetectable		 6bsgA-4dlqA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		5 / 10 LEU A 651
VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 1.48A 6bsiA-4dlqA:
undetectable		 6bsiA-4dlqA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4dlq LATROPHILIN-1
(Rattus
norvegicus) 		5 / 10 LEU A 651
VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 1.48A 6bsjA-4dlqA:
undetectable		 6bsjA-4dlqA:
9.97