SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4dm4 CELL DIVISION
CONTROL PROTEIN 73
(Saccharomyces
cerevisiae) 		5 / 11 GLU A 127
PHE A 110
PHE A 146
ILE A   9
PRO A  10
 None
 1.27A 2w3aA-4dm4A:
undetectable		 2w3aA-4dm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4dm4 CELL DIVISION
CONTROL PROTEIN 73
(Saccharomyces
cerevisiae) 		4 / 8 ILE A   9
ALA A  80
LEU A 150
ILE A  62
 None
 0.84A 2w9sE-4dm4A:
undetectable		 2w9sE-4dm4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 4dm4 CELL DIVISION
CONTROL PROTEIN 73
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 110
ASN A  21
PHE A  25
ILE A   7
PHE A  82
 None
 1.38A 3t3qA-4dm4A:
undetectable		 3t3qA-4dm4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 4dm4 CELL DIVISION
CONTROL PROTEIN 73
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 110
ASN A  21
PHE A  25
ILE A   7
PHE A  82
 None
 1.36A 3t3qB-4dm4A:
undetectable		 3t3qB-4dm4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4dm4 CELL DIVISION
CONTROL PROTEIN 73
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 110
ASN A  21
PHE A  25
ILE A   7
PHE A  82
 None
 1.37A 3t3qD-4dm4A:
undetectable		 3t3qD-4dm4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4dm4 CELL DIVISION
CONTROL PROTEIN 73
(Saccharomyces
cerevisiae) 		4 / 7 PHE A  82
GLY A 107
THR A  84
PHE A 110
 None
 1.17A 3vnsA-4dm4A:
undetectable		 3vnsA-4dm4A:
13.36