SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dmg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 7 LEU A 259
ALA A 255
LEU A 261
VAL A 225
 None
 1.01A 1dvxB-4dmgA:
undetectable		 1dvxB-4dmgA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		5 / 10 LEU A 316
LEU A 313
ALA A 312
LEU A 286
HIS A 283
 None
 1.33A 1gwrA-4dmgA:
undetectable		 1gwrA-4dmgA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.03A 1rg9A-4dmgA:
undetectable		 1rg9A-4dmgA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.04A 1rg9B-4dmgA:
undetectable		 1rg9B-4dmgA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.04A 1rg9C-4dmgA:
undetectable		 1rg9C-4dmgA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		5 / 12 GLU A 180
ARG A 205
ASP A 243
ALA A 248
ILE A 187
 None
SAM  A 401 (-4.1A)
SAM  A 401 (-2.9A)
None
None
 1.08A 1s14B-4dmgA:
undetectable		 1s14B-4dmgA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 7 LEU A 259
ALA A 255
LEU A 261
VAL A 225
 None
 0.95A 1tyrB-4dmgA:
undetectable		 1tyrB-4dmgA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 ARG A 258
GLU A 177
LEU A 252
VAL A 225
 None
 0.86A 2bxgA-4dmgA:
undetectable		 2bxgA-4dmgA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 7 GLU A 128
PRO A  57
ARG A 125
GLY A 126
 None
 1.02A 2hs1B-4dmgA:
undetectable		 2hs1B-4dmgA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.09A 2obvA-4dmgA:
undetectable		 2obvA-4dmgA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.00A 2p02A-4dmgA:
undetectable		 2p02A-4dmgA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		5 / 12 LEU A 315
PHE A 281
VAL A 284
ALA A 270
THR A 273
 None
None
None
SAM  A 401 (-3.7A)
None
 0.96A 3mdvB-4dmgA:
undetectable		 3mdvB-4dmgA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 7 LEU A 259
ALA A 255
LEU A 261
VAL A 225
 None
 1.05A 3ozkB-4dmgA:
undetectable		 3ozkB-4dmgA:
16.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DMG_A_SAMA401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		12 / 12 GLN A 193
TYR A 198
ARG A 205
TYR A 222
TYR A 224
ASP A 243
LYS A 244
ASP A 245
GLU A 269
ALA A 270
ASP A 287
PRO A 289
 SAM  A 401 (-3.3A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.1A)
SAM  A 401 (-4.5A)
SAM  A 401 (-4.5A)
SAM  A 401 (-2.9A)
SAM  A 401 (-4.2A)
SAM  A 401 (-4.9A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.3A)
 0.00A 4dmgA-4dmgA:
65.5		 4dmgA-4dmgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DMG_B_SAMB401_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		11 / 11 TYR A 198
ARG A 205
TYR A 222
TYR A 224
ASP A 243
LYS A 244
ASP A 245
GLU A 269
ALA A 270
ASP A 287
PRO A 289
 SAM  A 401 (-3.7A)
SAM  A 401 (-4.1A)
SAM  A 401 (-4.5A)
SAM  A 401 (-4.5A)
SAM  A 401 (-2.9A)
SAM  A 401 (-4.2A)
SAM  A 401 (-4.9A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
SAM  A 401 (-3.7A)
SAM  A 401 (-4.3A)
 0.30A 4dmgB-4dmgA:
60.0		 4dmgB-4dmgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		5 / 12 LEU A 305
LEU A 331
ARG A 303
SER A 328
THR A 290
 None
 1.13A 4f4dB-4dmgA:
undetectable		 4f4dB-4dmgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		5 / 12 ALA A  51
PHE A  77
MET A 127
LEU A 138
PHE A  78
 None
 1.27A 4iaqA-4dmgA:
undetectable		 4iaqA-4dmgA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		5 / 10 LEU A 315
PHE A 281
VAL A 284
ALA A 270
THR A 273
 None
None
None
SAM  A 401 (-3.7A)
None
 0.94A 4j14A-4dmgA:
undetectable		 4j14A-4dmgA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.04A 4kttA-4dmgA:
undetectable		 4kttA-4dmgA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.01A 4kttC-4dmgA:
undetectable		 4kttC-4dmgA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.02A 4ndnA-4dmgA:
undetectable		 4ndnA-4dmgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.06A 5a1iA-4dmgA:
undetectable		 5a1iA-4dmgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 6 LEU A 259
ALA A 255
LEU A 261
VAL A 225
 None
 1.03A 5a6iA-4dmgA:
undetectable		 5a6iA-4dmgA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 5 LEU A 259
ALA A 255
LEU A 261
VAL A 225
 None
 1.04A 5cr1A-4dmgA:
undetectable		 5cr1A-4dmgA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.07A 5t8sB-4dmgA:
undetectable		 5t8sB-4dmgA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 4 VAL A  52
ALA A  42
PHE A  49
PHE A  68
 None
 1.46A 6cbdA-4dmgA:
1.1		 6cbdA-4dmgA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 5 PHE A  78
VAL A 147
MET A 127
VAL A 133
 None
 0.96A 6ekzA-4dmgA:
undetectable		 6ekzA-4dmgA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 0.99A 6fbnB-4dmgA:
undetectable		 6fbnB-4dmgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.07A 6fboA-4dmgA:
undetectable		 6fboA-4dmgA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.06A 6fcbA-4dmgA:
undetectable		 6fcbA-4dmgA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 8 PRO A 360
ASP A 362
SER A  95
ASP A 200
 None
 1.08A 6fcdA-4dmgA:
undetectable		 6fcdA-4dmgA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493
(Thermus
thermophilus) 		4 / 4 ARG A 131
GLU A 128
GLU A 149
ARG A 156
 None
 1.19A 6fk2A-4dmgA:
undetectable		 6fk2A-4dmgA:
15.78