SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dn2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 4dn2 NITROREDUCTASE
(Geobacter
metallireducens) 		4 / 8 PHE A 136
LEU A  83
ALA A  82
VAL A 131
 None
 0.89A 1epbB-4dn2A:
undetectable		 1epbB-4dn2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 4dn2 NITROREDUCTASE
(Geobacter
metallireducens) 		4 / 8 LEU A  -4
GLY A 127
TYR A  -3
GLU A  22
 None
 1.01A 1jlfA-4dn2A:
undetectable
1jlfB-4dn2A:
undetectable		 1jlfA-4dn2A:
16.70
1jlfB-4dn2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4dn2 NITROREDUCTASE
(Geobacter
metallireducens) 		4 / 6 PHE A  16
ALA A  79
LEU A  83
ALA A  86
 None
FMN  A 300 (-3.3A)
None
None
 0.95A 2vcvB-4dn2A:
undetectable		 2vcvB-4dn2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4dn2 NITROREDUCTASE
(Geobacter
metallireducens) 		4 / 6 PHE A  16
ALA A  79
LEU A  83
ALA A  86
 None
FMN  A 300 (-3.3A)
None
None
 0.93A 2vcvK-4dn2A:
undetectable		 2vcvK-4dn2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 4dn2 NITROREDUCTASE
(Geobacter
metallireducens) 		5 / 11 ALA A 149
LEU A 151
ARG A 152
ILE A 153
GLY A 142
 None
 1.03A 3bpxA-4dn2A:
undetectable
3bpxB-4dn2A:
undetectable		 3bpxA-4dn2A:
21.60
3bpxB-4dn2A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 4dn2 NITROREDUCTASE
(Geobacter
metallireducens) 		4 / 4 LEU A  62
LEU A 145
GLY A 142
GLU A 143
 None
 1.28A 5hhjA-4dn2A:
undetectable		 5hhjA-4dn2A:
20.39