SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dn7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 11 VAL A 159
GLY A 129
TYR A 130
GLY A 190
MET A 206
 None
 1.33A 1iolA-4dn7A:
undetectable		 1iolA-4dn7A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 10 TYR A 130
THR A 146
THR A 140
VAL A  88
VAL A 134
 None
 1.39A 1o76A-4dn7A:
undetectable		 1o76A-4dn7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 ILE A 265
THR A 403
GLY A 374
LEU A 322
LEU A 324
 None
None
None
1PE  A 501 (-4.7A)
None
 0.99A 1rjdB-4dn7A:
undetectable		 1rjdB-4dn7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 ILE A 265
THR A 403
GLY A 374
LEU A 322
LEU A 324
 None
None
None
1PE  A 501 (-4.7A)
None
 1.00A 1rjdC-4dn7A:
undetectable		 1rjdC-4dn7A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 11 THR A 285
ASN A 309
GLU A 337
LEU A 345
ILE A 343
 None
 1.44A 1t6zA-4dn7A:
undetectable		 1t6zA-4dn7A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLY A 255
ALA A 256
ILE A 196
GLY A 200
GLY A 199
 None
 0.83A 2avsA-4dn7A:
undetectable		 2avsA-4dn7A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLY A 255
ALA A 256
ILE A 196
GLY A 200
GLY A 199
 None
 0.74A 2avvA-4dn7A:
undetectable		 2avvA-4dn7A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLY A 255
ALA A 256
ILE A 196
GLY A 200
GLY A 199
 None
 0.87A 2avvD-4dn7A:
undetectable		 2avvD-4dn7A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		3 / 3 THR A 178
ASP A  48
SER A  46
 None
 0.82A 2nxeA-4dn7A:
undetectable		 2nxeA-4dn7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		3 / 3 THR A 178
ASP A  48
SER A  46
 None
 0.76A 2nxeB-4dn7A:
undetectable		 2nxeB-4dn7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		4 / 8 SER A 192
THR A 220
PRO A 247
LEU A 260
 None
 1.17A 2v0zO-4dn7A:
undetectable		 2v0zO-4dn7A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLY A 176
LEU A 148
PHE A 204
HIS A 188
PRO A 218
 None
 1.22A 2y7kD-4dn7A:
undetectable		 2y7kD-4dn7A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		4 / 6 TYR A 130
THR A 146
VAL A  88
VAL A 134
 None
 0.99A 2z97A-4dn7A:
undetectable		 2z97A-4dn7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 LEU A  74
VAL A  73
SER A  79
SER A  51
HIS A 188
 None
 1.27A 2zlcA-4dn7A:
undetectable		 2zlcA-4dn7A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		3 / 3 THR A 248
PRO A 247
THR A 220
 None
 0.91A 316dC-4dn7A:
undetectable		 316dC-4dn7A:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		4 / 8 LEU A 103
ILE A 162
HIS A 160
TYR A 195
 None
None
None
1PE  A 500 (-4.7A)
 0.95A 3b9lA-4dn7A:
2.9		 3b9lA-4dn7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		4 / 5 VAL A 222
VAL A 249
THR A 201
THR A 220
 None
 1.28A 3bjwG-4dn7A:
undetectable		 3bjwG-4dn7A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLY A 255
ALA A 256
ILE A 196
GLY A 200
GLY A 199
 None
 0.85A 3cyxB-4dn7A:
undetectable		 3cyxB-4dn7A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		4 / 4 ILE A 163
ARG A  67
ILE A 132
THR A 220
 None
 1.02A 3ia4C-4dn7A:
undetectable		 3ia4C-4dn7A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 ASP A  48
LEU A  47
THR A 178
LEU A  72
LEU A  55
 None
 1.12A 3k2hA-4dn7A:
undetectable		 3k2hA-4dn7A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		6 / 12 GLY A 312
GLY A 253
GLY A 255
SER A 223
ALA A 282
ASN A 281
 None
None
None
1PE  A 500 ( 4.6A)
None
None
 1.43A 3kkzB-4dn7A:
undetectable		 3kkzB-4dn7A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 ILE A 296
GLY A 298
ALA A 266
SER A 270
LEU A 272
 None
 1.06A 3n8xA-4dn7A:
undetectable		 3n8xA-4dn7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 ILE A 296
GLY A 298
ALA A 266
SER A 270
LEU A 272
 None
 1.12A 3n8xB-4dn7A:
undetectable		 3n8xB-4dn7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 11 ILE A 296
GLY A 298
ALA A 266
SER A 270
LEU A 272
 None
 1.17A 3n8yA-4dn7A:
undetectable		 3n8yA-4dn7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 10 ALA A 302
LEU A 289
ALA A 278
VAL A 222
THR A 220
 None
 1.09A 3r9cA-4dn7A:
2.4		 3r9cA-4dn7A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLY A 253
GLY A 255
SER A 223
ALA A 282
ASN A 281
 None
None
1PE  A 500 ( 4.6A)
None
None
 1.45A 3t7sC-4dn7A:
undetectable		 3t7sC-4dn7A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 9 SER A 107
ILE A 162
ASP A 128
ALA A 127
THR A 122
 None
 1.26A 4r1zA-4dn7A:
undetectable		 4r1zA-4dn7A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		4 / 5 SER A 242
GLY A 215
ARG A 241
GLU A  24
 None
 1.21A 4r82A-4dn7A:
undetectable
4r82B-4dn7A:
undetectable		 4r82A-4dn7A:
19.19
4r82B-4dn7A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 GLY A  66
GLY A  69
SER A  68
MET A 142
SER A  63
 None
 1.13A 5hikA-4dn7A:
undetectable		 5hikA-4dn7A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		3 / 3 LEU A 148
TYR A 130
SER A 192
 None
 0.80A 5iktA-4dn7A:
undetectable		 5iktA-4dn7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		3 / 3 TYR A 234
TYR A 130
SER A 192
 None
 0.99A 5iktB-4dn7A:
undetectable		 5iktB-4dn7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 LEU A 251
ILE A 279
VAL A 222
TYR A 246
ALA A 287
 None
 1.13A 6ajiA-4dn7A:
undetectable		 6ajiA-4dn7A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		5 / 12 ALA A 120
SER A  35
THR A 158
LEU A 189
ALA A 156
 None
 1.02A 6djzC-4dn7A:
undetectable		 6djzC-4dn7A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN
(Methanosarcina
mazei) 		3 / 3 ARG A  67
GLY A  66
GLU A  65
 None
 0.61A 6fgdA-4dn7A:
undetectable		 6fgdA-4dn7A:
19.78