SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dna'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		6 / 12 VAL A 260
LEU A 151
ILE A 199
GLY A 177
ALA A 176
LEU A 262
 None
 1.32A 1eqhA-4dnaA:
0.4		 1eqhA-4dnaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		6 / 12 VAL A 260
LEU A 151
ILE A 199
GLY A 177
ALA A 176
LEU A 262
 None
 1.29A 1eqhB-4dnaA:
undetectable		 1eqhB-4dnaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		6 / 10 LEU A 174
ALA A 186
ILE A 181
GLY A 179
GLY A 178
ILE A 175
 None
None
FAD  A 500 ( 4.4A)
None
None
None
 1.35A 1sdvA-4dnaA:
undetectable		 1sdvA-4dnaA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 SER A 160
ILE A 181
LEU A 206
PHE A 185
ALA A 344
 FAD  A 500 ( 4.2A)
FAD  A 500 ( 4.4A)
None
None
None
 1.08A 1tsnA-4dnaA:
undetectable		 1tsnA-4dnaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 LEU A 275
VAL A 280
GLY A 279
GLY A 272
LEU A 273
 None
None
None
None
FAD  A 500 (-4.3A)
 0.91A 2v3kA-4dnaA:
undetectable		 2v3kA-4dnaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 8 LEU A 273
LEU A 117
ALA A  34
PHE A   9
 FAD  A 500 (-4.3A)
None
None
None
 0.71A 2vcvP-4dnaA:
undetectable		 2vcvP-4dnaA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 10 ILE A 351
LEU A 198
LEU A 206
GLY A 179
ALA A 182
 None
 1.08A 2xf3A-4dnaA:
undetectable		 2xf3A-4dnaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 7 GLY A  14
ALA A 317
VAL A 138
ILE A  33
 FAD  A 500 (-3.2A)
FAD  A 500 ( 3.8A)
None
None
 0.76A 3a2qA-4dnaA:
undetectable		 3a2qA-4dnaA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		6 / 12 GLY A  21
ILE A  33
TYR A  99
GLY A  41
SER A  15
GLY A  17
 None
None
None
FAD  A 500 (-3.4A)
FAD  A 500 (-3.9A)
None
 1.36A 3hs6B-4dnaA:
undetectable		 3hs6B-4dnaA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 6 THR A 159
ILE A 158
THR A 196
PHE A 189
 None
 1.01A 4acbC-4dnaA:
2.4		 4acbC-4dnaA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 134
GLY A 300
ILE A 288
THR A 282
LEU A 275
 None
 1.16A 4n48B-4dnaA:
undetectable		 4n48B-4dnaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 7 GLY A  14
GLY A  13
ALA A 140
ILE A  33
 FAD  A 500 (-3.2A)
FAD  A 500 (-4.4A)
FAD  A 500 (-4.5A)
None
 0.69A 4yjiA-4dnaA:
undetectable		 4yjiA-4dnaA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 404
GLY A 355
GLY A 420
LEU A 419
ALA A 361
 None
 0.98A 5c0oG-4dnaA:
3.0		 5c0oG-4dnaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 GLN A 235
HIS A 252
ILE A 233
ILE A 199
 None
 1.20A 5dnuA-4dnaA:
undetectable		 5dnuA-4dnaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		4 / 5 GLN A 235
HIS A 252
ILE A 233
ILE A 199
 None
 1.28A 5dnvA-4dnaA:
undetectable		 5dnvA-4dnaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 4dna PROBABLE GLUTATHIONE
REDUCTASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A  11
PHE A 324
ALA A 321
ALA A  25
GLU A 109
 FAD  A 500 (-4.8A)
None
None
None
None
 1.12A 5vceA-4dnaA:
undetectable		 5vceA-4dnaA:
22.56