SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		4 / 4 GLY A 186
SER A 151
ILE A 164
HIS A 176
 None
 1.34A 1yajJ-4dngA:
undetectable		 1yajJ-4dngA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		4 / 5 LEU A  79
ILE A  90
SER A 185
GLY A 187
 None
 0.83A 2otfA-4dngA:
undetectable		 2otfA-4dngA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		5 / 12 TYR A  30
GLY A 327
ILE A 330
VAL A 359
GLY A 360
 None
 0.97A 2qe6B-4dngA:
3.3		 2qe6B-4dngA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		5 / 12 ILE A 276
PHE A 280
PHE A 383
ALA A 387
ASN A 258
 None
 0.99A 2rlcA-4dngA:
undetectable		 2rlcA-4dngA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		5 / 11 PHE A 383
SER A 430
ILE A 428
ALA A 402
GLU A 253
 None
 1.24A 2v0mA-4dngA:
0.3		 2v0mA-4dngA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		5 / 12 ALA A 353
VAL A 367
ILE A 293
PHE A 307
LYS A 306
 None
 0.93A 2v95A-4dngA:
undetectable		 2v95A-4dngA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		4 / 7 PRO A 385
PRO A 328
GLY A 327
THR A 364
 None
 1.02A 2vl2B-4dngA:
undetectable		 2vl2B-4dngA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		5 / 11 ALA A 115
LEU A 112
ILE A 168
ILE A 190
THR A 119
 None
 1.05A 2w9sA-4dngA:
undetectable		 2w9sA-4dngA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		5 / 10 ALA A 115
LEU A 112
ILE A 168
ILE A 190
THR A 119
 None
 1.05A 2w9sC-4dngA:
undetectable		 2w9sC-4dngA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		4 / 7 ILE A 330
LEU A 329
GLY A 327
GLY A  96
 None
 0.80A 2wd9A-4dngA:
undetectable		 2wd9A-4dngA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		4 / 5 ILE A 150
SER A 151
PRO A 152
PRO A 156
 None
 1.29A 3bjwC-4dngA:
undetectable		 3bjwC-4dngA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		3 / 3 LYS A 288
ARG A 162
LEU A 409
 None
 1.17A 3v4tE-4dngA:
undetectable		 3v4tE-4dngA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		5 / 12 GLY A  96
GLY A 327
ASN A 361
THR A 102
ALA A  91
 None
 0.93A 4uckA-4dngA:
2.4		 4uckA-4dngA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		5 / 12 THR A 188
THR A 209
ALA A  41
ALA A  38
THR A  36
 None
 1.18A 5lf7V-4dngA:
undetectable
5lf7b-4dngA:
undetectable		 5lf7V-4dngA:
19.69
5lf7b-4dngA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4dng UNCHARACTERIZED
ALDEHYDE
DEHYDROGENASE ALDY
(Bacillus
subtilis) 		5 / 12 THR A 188
THR A 209
ALA A  41
ALA A  38
THR A  36
 None
 1.17A 5lf7H-4dngA:
undetectable
5lf7N-4dngA:
undetectable		 5lf7H-4dngA:
19.69
5lf7N-4dngA:
18.16