SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 7 PHE A 161
GLY A 208
ARG A 207
GLY A 165
 None
None
None
FAD  A 501 (-3.6A)
 0.86A 11gsB-4dnsA:
undetectable		 11gsB-4dnsA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 6 GLU A 276
ILE A 310
TYR A 135
GLY A 146
 None
 0.97A 1maaB-4dnsA:
undetectable
1maaD-4dnsA:
undetectable		 1maaB-4dnsA:
21.44
1maaD-4dnsA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 12 LEU A  14
ALA A  28
PRO A  55
PHE A 487
ILE A  59
 None
 1.21A 1mx8A-4dnsA:
undetectable		 1mx8A-4dnsA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 8 SER A 342
LEU A 442
ASP A 443
GLU A  98
 None
 0.93A 1mxgA-4dnsA:
undetectable		 1mxgA-4dnsA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 12 PHE A 166
ILE A 357
LEU A 361
SER A 342
ILE A 398
 FAD  A 501 (-4.1A)
None
None
None
None
 1.22A 2e7fA-4dnsA:
undetectable		 2e7fA-4dnsA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		3 / 3 SER A 115
ASP A 133
ASP A 126
 None
 0.62A 2plwA-4dnsA:
undetectable		 2plwA-4dnsA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 12 ALA A 123
LEU A 224
PHE A 147
VAL A 157
GLY A 158
 None
None
None
None
FAD  A 501 ( 3.8A)
 0.96A 2ve3A-4dnsA:
undetectable		 2ve3A-4dnsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 12 PHE A 166
ILE A 357
LEU A 361
SER A 342
ILE A 398
 FAD  A 501 (-4.1A)
None
None
None
None
 1.26A 2ycjA-4dnsA:
undetectable		 2ycjA-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB304_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 4 ARG A  96
VAL A  53
LYS A  99
GLU A  98
 None
 1.49A 3deuB-4dnsA:
0.0		 3deuB-4dnsA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		3 / 3 ASN A 489
GLU A 490
ARG A 440
 FAD  A 501 (-4.4A)
None
FAD  A 501 (-3.9A)
 0.91A 3wxoA-4dnsA:
undetectable		 3wxoA-4dnsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		3 / 3 LYS A 184
LEU A 192
ALA A 218
 None
 0.73A 4iizA-4dnsA:
undetectable		 4iizA-4dnsA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 6 ASN A 489
GLU A  91
GLU A 490
GLU A  98
 FAD  A 501 (-4.4A)
None
None
None
 1.39A 4mi4A-4dnsA:
undetectable		 4mi4A-4dnsA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 7 ASN A 489
GLU A  91
GLU A 490
GLU A  98
 FAD  A 501 (-4.4A)
None
None
None
 1.30A 4r87I-4dnsA:
undetectable		 4r87I-4dnsA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 5 TYR A 439
GLY A 150
TYR A  90
GLY A  87
 FAD  A 501 (-4.8A)
FAD  A 501 (-3.5A)
FAD  A 501 (-4.5A)
FAD  A 501 (-3.2A)
 0.98A 5ayfA-4dnsA:
undetectable		 5ayfA-4dnsA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 6 ILE A 206
ALA A 176
VAL A 180
HIS A 160
 None
None
None
FAD  A 501 (-3.9A)
 0.88A 5eclD-4dnsA:
undetectable		 5eclD-4dnsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 8 ILE A 206
ALA A 176
VAL A 180
HIS A 160
 None
None
None
FAD  A 501 (-3.9A)
 0.88A 5ecnD-4dnsA:
undetectable		 5ecnD-4dnsA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 8 PHE A 358
ILE A 245
GLY A 272
LEU A 297
 None
 0.85A 5hs1A-4dnsA:
undetectable		 5hs1A-4dnsA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 5 HIS A 160
VAL A 125
GLY A 128
ALA A 129
 FAD  A 501 (-3.9A)
None
None
None
 1.04A 5hwaA-4dnsA:
undetectable		 5hwaA-4dnsA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_A_KANA600_1
(BIFUNCTIONAL AAC/APH)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 12 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
 None
 1.45A 5iqbA-4dnsA:
0.2		 5iqbA-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 11 ASP A 485
ASN A 447
ASP A 482
GLU A 101
GLU A 490
 None
 1.33A 5iqbB-4dnsA:
undetectable		 5iqbB-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_B_KANB600_1
(BIFUNCTIONAL AAC/APH)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 11 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
 None
 1.45A 5iqbB-4dnsA:
undetectable		 5iqbB-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 11 ASP A 485
ASN A 447
ASP A 482
GLU A 101
GLU A 490
 None
 1.32A 5iqbC-4dnsA:
0.0		 5iqbC-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_C_KANC600_1
(BIFUNCTIONAL AAC/APH)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 11 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
 None
 1.42A 5iqbC-4dnsA:
0.0		 5iqbC-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQB_D_KAND600_1
(BIFUNCTIONAL AAC/APH)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 12 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
 None
 1.44A 5iqbD-4dnsA:
undetectable		 5iqbD-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_C_NMYC600_1
(BIFUNCTIONAL AAC/APH)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 12 ASP A 485
SER A 454
ASN A 447
ASP A 482
GLU A 490
 None
 1.48A 5iqeC-4dnsA:
undetectable		 5iqeC-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 6 PRO A 387
GLY A 163
PHE A 467
ARG A 390
 None
 1.44A 5jcnB-4dnsA:
undetectable		 5jcnB-4dnsA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 5 ALA A 104
VAL A 106
PHE A  13
ILE A  67
 None
 0.91A 5of1B-4dnsA:
undetectable		 5of1B-4dnsA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA304_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		4 / 4 ARG A 391
THR A 386
GLY A 164
PHE A 388
 None
 1.01A 5uunA-4dnsA:
0.0		 5uunA-4dnsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 10 ASP A 485
ASN A 447
GLU A 101
SER A  97
GLU A 490
 None
 1.38A 6c5uA-4dnsA:
0.0		 6c5uA-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C5U_D_RIOD600_0
(BIFUNCTIONAL AAC/APH)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 10 ASP A 485
ASN A 447
GLU A 101
SER A  97
GLU A 490
 None
 1.37A 6c5uD-4dnsA:
0.0		 6c5uD-4dnsA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4dns FAD-LINKED
OXIDOREDUCTASE BG60
(Cynodon
dactylon) 		5 / 12 ASN A 333
PRO A 317
ILE A 316
VAL A 313
ILE A 370
 None
 1.40A 6j21A-4dnsA:
undetectable		 6j21A-4dnsA:
22.09