SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dnv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 4dnv AT5G63860/MGI19_6
(Arabidopsis
thaliana) 		5 / 10 THR A 340
GLY A 283
HIS A 287
ALA A 290
ILE A 237
 None
 1.35A 1gtfG-4dnvA:
undetectable
1gtfH-4dnvA:
undetectable		 1gtfG-4dnvA:
13.90
1gtfH-4dnvA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4dnv AT5G63860/MGI19_6
(Arabidopsis
thaliana) 		4 / 6 PHE A 370
GLN A 316
ASN A 303
LEU A 270
 None
 1.19A 2nyrA-4dnvA:
undetectable		 2nyrA-4dnvA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 4dnv AT5G63860/MGI19_6
(Arabidopsis
thaliana) 		3 / 3 GLY A 355
ASP A 367
SER A 365
 None
 0.69A 2qhfA-4dnvA:
undetectable		 2qhfA-4dnvA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 4dnv AT5G63860/MGI19_6
(Arabidopsis
thaliana) 		5 / 10 GLY A  40
GLN A 359
LEU A 341
ALA A  22
ALA A  76
 None
 1.31A 4wnuD-4dnvA:
undetectable		 4wnuD-4dnvA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4dnv AT5G63860/MGI19_6
(Arabidopsis
thaliana) 		5 / 12 LEU A 133
VAL A 135
VAL A 229
TYR A 248
GLY A 195
 None
 1.38A 5i8fA-4dnvA:
undetectable		 5i8fA-4dnvA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4dnv AT5G63860/MGI19_6
(Arabidopsis
thaliana) 		6 / 12 PRO A 111
VAL A  72
ALA A  29
VAL A  36
LEU A 377
GLY A 361
 None
 1.39A 5igtA-4dnvA:
undetectable		 5igtA-4dnvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4dnv AT5G63860/MGI19_6
(Arabidopsis
thaliana) 		6 / 12 PRO A 215
VAL A 177
ALA A 134
VAL A 141
LEU A 117
GLY A 101
 None
 1.31A 5igtA-4dnvA:
undetectable		 5igtA-4dnvA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4dnv AT5G63860/MGI19_6
(Arabidopsis
thaliana) 		5 / 12 LEU A 291
ALA A 290
THR A 288
LEU A 270
PRO A 319
 None
 1.15A 5k9dA-4dnvA:
undetectable		 5k9dA-4dnvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 4dnv AT5G63860/MGI19_6
(Arabidopsis
thaliana) 		4 / 6 LEU A 360
TRP A  39
SER A  57
GLY A 363
 None
 1.09A 5o4yF-4dnvA:
undetectable		 5o4yF-4dnvA:
4.98