SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 HIS A 205
TYR A 390
TYR A 391
VAL A 242
PRO A 239
 None
 1.37A 1ituB-4dnxA:
undetectable		 1ituB-4dnxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		4 / 8 ILE A  99
LEU A 101
PHE A  58
GLY A  57
 None
 1.06A 1os6A-4dnxA:
undetectable		 1os6A-4dnxA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 10 ALA A  44
ALA A  40
VAL A 163
GLY A 266
ASP A 103
 None
 1.02A 2f16K-4dnxA:
undetectable
2f16L-4dnxA:
undetectable		 2f16K-4dnxA:
21.52
2f16L-4dnxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 10 ALA A  44
ALA A  40
VAL A 163
GLY A 266
ASP A 103
 None
 1.01A 2f16Y-4dnxA:
undetectable
2f16Z-4dnxA:
undetectable		 2f16Y-4dnxA:
21.52
2f16Z-4dnxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		4 / 5 LEU A 229
VAL A 364
LEU A 368
ARG A 206
 None
 1.09A 2oiqA-4dnxA:
undetectable		 2oiqA-4dnxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		4 / 5 LEU A 229
VAL A 364
LEU A 368
ARG A 380
 None
 0.93A 2oiqA-4dnxA:
undetectable		 2oiqA-4dnxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 PHE A 267
LEU A  10
PHE A 283
LEU A 279
LEU A  83
 None
 1.47A 3adsA-4dnxA:
undetectable		 3adsA-4dnxA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		4 / 5 ALA A  40
LEU A  47
GLY A  57
THR A  74
 None
 0.85A 3dl9A-4dnxA:
undetectable		 3dl9A-4dnxA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		3 / 3 SER A 360
GLY A 361
THR A 362
 None
 0.17A 3k9wA-4dnxA:
9.0		 3k9wA-4dnxA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		4 / 6 ILE A  99
LEU A 101
PHE A  58
GLY A  57
 None
 1.01A 3sj1X-4dnxA:
undetectable		 3sj1X-4dnxA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		4 / 5 THR A 179
GLY A  50
PRO A  12
TYR A  16
 None
 1.09A 3u8qA-4dnxA:
undetectable		 3u8qA-4dnxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		4 / 5 THR A 179
GLY A  50
PRO A  12
TYR A  16
 None
 1.05A 4grkA-4dnxA:
undetectable		 4grkA-4dnxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		4 / 7 ILE A  99
LEU A 101
PHE A  58
GLY A  57
 None
 1.04A 4hbfA-4dnxA:
undetectable		 4hbfA-4dnxA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		4 / 7 ILE A  99
LEU A 101
PHE A  58
GLY A  57
 None
 1.06A 4hc3A-4dnxA:
undetectable		 4hc3A-4dnxA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 GLN A 152
LEU A 270
ALA A  40
ASN A  43
LEU A  83
 None
 1.29A 4qckA-4dnxA:
undetectable		 4qckA-4dnxA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 MET A  46
VAL A  45
GLY A  42
ALA A  41
SER A  38
 None
 1.04A 4rrwA-4dnxA:
undetectable		 4rrwA-4dnxA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 MET A  46
VAL A  45
GLY A  42
ALA A  41
SER A  38
 None
 1.03A 4rrwB-4dnxA:
undetectable		 4rrwB-4dnxA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 MET A  46
VAL A  45
GLY A  42
ALA A  41
SER A  38
 None
 1.04A 4rrzA-4dnxA:
undetectable		 4rrzA-4dnxA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 MET A  46
VAL A  45
GLY A  42
ALA A  41
SER A  38
 None
 1.03A 4rrzB-4dnxA:
undetectable		 4rrzB-4dnxA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 9 GLN A 285
LEU A  10
ALA A 289
ARG A 184
ALA A 180
 None
 1.46A 5g44A-4dnxA:
undetectable		 5g44A-4dnxA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 ASP A 316
ALA A 317
PRO A 274
GLY A 137
THR A 132
 None
 1.24A 5hfjA-4dnxA:
undetectable		 5hfjA-4dnxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 ASP A 316
ALA A 317
PRO A 274
GLY A 137
THR A 132
 None
 1.20A 5hfjC-4dnxA:
undetectable		 5hfjC-4dnxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 ASP A 316
ALA A 317
PRO A 274
GLY A 137
THR A 132
 None
 1.23A 5hfjD-4dnxA:
undetectable		 5hfjD-4dnxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 ASP A 316
ALA A 317
PRO A 274
GLY A 137
THR A 132
 None
 1.19A 5hfjH-4dnxA:
undetectable		 5hfjH-4dnxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		3 / 3 ASP A   8
ASN A 286
GLN A 285
 None
 0.64A 5k7uA-4dnxA:
1.0		 5k7uA-4dnxA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 4dnx SULFATE
ADENYLYLTRANSFERASE
(Allochromatium
vinosum) 		5 / 12 PHE A 255
ALA A 251
ALA A 277
ALA A 281
MET A 216
 None
 1.07A 5tl8A-4dnxA:
undetectable		 5tl8A-4dnxA:
22.65