SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4do7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		5 / 11 HIS A   9
HIS A  11
GLU A  62
GLY A  81
ILE A  52
 ZN  A 401 (-4.2A)
ZN  A 401 (-3.3A)
None
None
None
 1.05A 1jzsA-4do7A:
undetectable		 1jzsA-4do7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		5 / 12 LEU A 189
ALA A 230
PHE A 234
GLY A 168
LEU A 260
 None
 1.20A 1kglA-4do7A:
undetectable		 1kglA-4do7A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		4 / 7 LEU A 189
ALA A 167
ILE A 223
PRO A 170
 None
 0.97A 1oniB-4do7A:
0.8
1oniC-4do7A:
0.7		 1oniB-4do7A:
22.36
1oniC-4do7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		5 / 12 LEU A 249
GLY A 204
ARG A 106
LEU A  39
VAL A 261
 None
None
ZN  A 401 ( 4.4A)
None
None
 1.28A 2w8yA-4do7A:
undetectable		 2w8yA-4do7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		4 / 5 HIS A   9
LEU A  42
LEU A 249
ASP A 255
 ZN  A 401 (-4.2A)
None
None
None
 1.29A 4aqlA-4do7A:
12.7		 4aqlA-4do7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		4 / 6 CYH A 226
LEU A 172
HIS A 166
LEU A 205
 None
None
ZN  A 401 (-4.6A)
None
 1.07A 5hpuC-4do7A:
undetectable
5hpuD-4do7A:
undetectable		 5hpuC-4do7A:
14.00
5hpuD-4do7A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		4 / 5 HIS A  11
HIS A   9
VAL A  54
ALA A  56
 ZN  A 401 (-3.3A)
ZN  A 401 (-4.2A)
None
None
 1.28A 5i3bB-4do7A:
undetectable		 5i3bB-4do7A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		5 / 12 ALA A 117
ASP A 149
PRO A 148
GLU A 144
PHE A 143
 None
 1.00A 5x6yC-4do7A:
undetectable		 5x6yC-4do7A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		4 / 6 TRP A 278
GLY A 235
ALA A 276
LEU A 277
 None
 0.90A 6fosA-4do7A:
undetectable		 6fosA-4do7A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4do7 AMIDOHYDROLASE 2
(Burkholderia
multivorans) 		3 / 3 TYR A 254
ASP A 255
GLN A  46
 None
 0.85A 6g1pA-4do7A:
undetectable		 6g1pA-4do7A:
21.89