SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4doh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4doh INTERLEUKIN-20
INTERLEUKIN-20
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 11 LEU A 152
ILE A  64
LEU A  65
TYR R  76
GLY A 163
 None
 1.12A 2bxmA-4dohA:
undetectable		 2bxmA-4dohA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4doh INTERLEUKIN-20
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		3 / 3 LYS R  39
TYR R  69
PRO R  59
 None
 1.15A 2j9cC-4dohR:
undetectable		 2j9cC-4dohR:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4doh INTERLEUKIN-20
(Homo
sapiens) 		4 / 8 PHE A  95
ILE A 109
PHE A 149
GLY A 163
 None
 0.96A 2qwxA-4dohA:
undetectable
2qwxB-4dohA:
undetectable		 2qwxA-4dohA:
21.46
2qwxB-4dohA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4doh INTERLEUKIN-20
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		5 / 12 ASN R 178
ILE R 137
THR R 135
ILE R 175
PRO R 158
 None
 1.19A 3kpbA-4dohR:
undetectable		 3kpbA-4dohR:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4doh INTERLEUKIN-20
INTERLEUKIN-20
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PHE R 132
PRO R 131
GLU R 134
GLY A 163
LEU A 165
 None
 1.41A 4oadA-4dohR:
undetectable		 4oadA-4dohR:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 4doh INTERLEUKIN-20
(Homo
sapiens) 		5 / 10 LEU A 169
ASP A 166
LEU A  65
LEU A  86
LEU A 112
 None
 1.07A 4odoA-4dohA:
undetectable		 4odoA-4dohA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 4doh INTERLEUKIN-20
INTERLEUKIN-20
RECEPTOR SUBUNIT
ALPHA
(Homo
sapiens) 		4 / 7 ILE A  64
LEU A  65
TYR R  76
GLY A 163
 None
 1.00A 4z69A-4dohA:
2.1		 4z69A-4dohA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4doh INTERLEUKIN-20
(Homo
sapiens) 		3 / 3 ARG A 124
HIS A 127
ARG A  84
 None
 1.11A 5iaoC-4dohA:
undetectable		 5iaoC-4dohA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4doh INTERLEUKIN-20
(Homo
sapiens) 		3 / 3 ARG A 124
HIS A 127
ARG A  84
 None
 1.10A 5iaoF-4dohA:
undetectable		 5iaoF-4dohA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 4doh INTERLEUKIN-20
(Homo
sapiens) 		4 / 6 THR A 118
LEU A 117
THR A  37
LEU A 112
 None
 1.20A 6mvxA-4dohA:
2.8
6mvxB-4dohA:
2.1
6mvxC-4dohA:
2.1		 6mvxA-4dohA:
20.49
6mvxB-4dohA:
20.49
6mvxC-4dohA:
20.49