SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dok'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		4 / 6 TYR A 185
TYR A 101
ILE A 158
ILE A  88
 None
 1.18A 2dcfA-4dokA:
undetectable		 2dcfA-4dokA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		5 / 12 ALA A  78
ASP A  77
ASP A  74
ILE A 200
LEU A 208
 None
 0.92A 2o4nA-4dokA:
undetectable		 2o4nA-4dokA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		5 / 9 GLU A  85
GLY A 154
PHE A 149
GLU A 157
ILE A 155
 None
 1.37A 2w98A-4dokA:
undetectable		 2w98A-4dokA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		5 / 12 THR A 196
ILE A  45
GLY A  29
GLY A  27
ARG A  89
 None
 1.30A 2y7kC-4dokA:
undetectable		 2y7kC-4dokA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		4 / 7 TYR A 185
TYR A 101
ILE A 158
ILE A  88
 None
 1.16A 2zm7A-4dokA:
undetectable		 2zm7A-4dokA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		6 / 12 PHE A 149
LEU A 186
ALA A  80
VAL A  90
ILE A 145
LEU A 105
 None
 1.49A 3oapA-4dokA:
undetectable		 3oapA-4dokA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		5 / 11 PHE A  75
ALA A  78
ALA A  82
ALA A  80
VAL A  47
 None
 1.02A 4j6cA-4dokA:
undetectable		 4j6cA-4dokA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		5 / 12 PHE A  75
ALA A  78
ALA A  82
ALA A  80
VAL A  47
 None
 1.06A 4j6dA-4dokA:
undetectable		 4j6dA-4dokA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		5 / 12 PHE A  75
ALA A  78
ALA A  82
ALA A  80
VAL A  47
 None
 1.07A 4jbtA-4dokA:
undetectable		 4jbtA-4dokA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		5 / 11 PHE A  75
ALA A  78
ALA A  82
ALA A  80
VAL A  47
 None
 1.08A 4jbtB-4dokA:
undetectable		 4jbtB-4dokA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		5 / 10 PHE A  75
ALA A 201
ASP A 202
SER A 205
ALA A 206
 None
 0.99A 4wnuD-4dokA:
undetectable		 4wnuD-4dokA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		4 / 6 SER A  81
GLY A 191
ARG A 190
GLY A 188
 None
 0.88A 5cdnA-4dokA:
undetectable
5cdnB-4dokA:
undetectable		 5cdnA-4dokA:
18.92
5cdnB-4dokA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		4 / 6 SER A  81
GLY A 191
ARG A 190
GLY A 188
 None
 0.83A 5cdnR-4dokA:
undetectable
5cdnS-4dokA:
undetectable		 5cdnR-4dokA:
18.92
5cdnS-4dokA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		4 / 6 SER A  81
GLY A 191
ARG A 190
GLY A 188
 None
 0.74A 5cdpA-4dokA:
undetectable
5cdpB-4dokA:
undetectable		 5cdpA-4dokA:
18.22
5cdpB-4dokA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		5 / 12 GLN A 182
ILE A  88
VAL A  87
GLY A  46
VAL A 207
 None
 1.11A 5ergB-4dokA:
undetectable		 5ergB-4dokA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE
(Arabidopsis
thaliana) 		4 / 7 ILE A  17
GLU A 157
HIS A 148
VAL A  87
 None
 0.95A 6j20A-4dokA:
undetectable		 6j20A-4dokA:
16.78