SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dol'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 4dol AT1G53520
(Arabidopsis
thaliana) 		3 / 3 ASP A 197
ASP A 192
LYS A 205
 None
 1.13A 1lqtB-4dolA:
undetectable		 1lqtB-4dolA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 4dol AT1G53520
(Arabidopsis
thaliana) 		3 / 3 ASP A 197
ASP A 192
LYS A 205
 None
 1.11A 1lquB-4dolA:
undetectable		 1lquB-4dolA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4dol AT1G53520
(Arabidopsis
thaliana) 		5 / 12 LEU A 204
GLY A  40
VAL A 208
VAL A  27
LEU A  29
 None
 1.16A 1mx1E-4dolA:
undetectable		 1mx1E-4dolA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4dol AT1G53520
(Arabidopsis
thaliana) 		5 / 10 LEU A 190
ALA A 116
ALA A 120
LEU A 136
PHE A 194
 None
PLM  A 301 (-3.5A)
PLM  A 301 ( 3.7A)
None
None
 1.20A 1rlbE-4dolA:
undetectable		 1rlbE-4dolA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4dol AT1G53520
(Arabidopsis
thaliana) 		4 / 8 TYR A  60
TRP A 158
CYH A  32
LEU A 165
 None
 1.45A 1uw6G-4dolA:
undetectable
1uw6H-4dolA:
undetectable		 1uw6G-4dolA:
21.15
1uw6H-4dolA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4dol AT1G53520
(Arabidopsis
thaliana) 		4 / 8 LEU A 165
TYR A  60
TRP A 158
CYH A  32
 None
 1.45A 1uw6P-4dolA:
undetectable
1uw6T-4dolA:
undetectable		 1uw6P-4dolA:
21.15
1uw6T-4dolA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 4dol AT1G53520
(Arabidopsis
thaliana) 		4 / 8 PRO A  30
LEU A 173
GLY A 172
LEU A 155
 None
 0.90A 1ya4A-4dolA:
undetectable		 1ya4A-4dolA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 4dol AT1G53520
(Arabidopsis
thaliana) 		4 / 7 PRO A  30
LEU A 173
GLY A 172
LEU A 155
 None
 0.89A 1ya4B-4dolA:
undetectable		 1ya4B-4dolA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4dol AT1G53520
(Arabidopsis
thaliana) 		5 / 11 PHE A 143
PHE A 113
ILE A 154
LEU A 117
PHE A 139
 None
PLM  A 301 (-4.8A)
PLM  A 301 (-4.4A)
PLM  A 301 ( 4.7A)
None
 1.08A 1z11B-4dolA:
undetectable		 1z11B-4dolA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 4dol AT1G53520
(Arabidopsis
thaliana) 		5 / 12 PHE A  88
LEU A  70
LEU A 216
ALA A 213
ILE A  81
 None
 1.23A 2bxpA-4dolA:
undetectable		 2bxpA-4dolA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 4dol AT1G53520
(Arabidopsis
thaliana) 		3 / 3 GLU A 131
GLY A 184
SER A 129
 None
 0.62A 4b53B-4dolA:
undetectable		 4b53B-4dolA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4dol AT1G53520
(Arabidopsis
thaliana) 		4 / 8 VAL A  62
TYR A  60
LEU A  87
LEU A  70
 None
 0.89A 4jtrA-4dolA:
undetectable		 4jtrA-4dolA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4dol AT1G53520
(Arabidopsis
thaliana) 		5 / 12 ALA A 120
LEU A 117
ALA A 116
PHE A 113
THR A 112
 PLM  A 301 ( 3.7A)
PLM  A 301 ( 4.7A)
PLM  A 301 (-3.5A)
PLM  A 301 (-4.8A)
None
 0.97A 5k9dA-4dolA:
undetectable		 5k9dA-4dolA:
23.27