SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4doo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.24A 1fm6X-4dooA:
undetectable		 1fm6X-4dooA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.13A 2prgB-4dooA:
undetectable		 2prgB-4dooA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		4 / 7 TYR A 181
ILE A 177
ARG A  30
PHE A 134
 None
None
DAO  A 301 (-3.8A)
DAO  A 301 (-3.9A)
 1.05A 2vctD-4dooA:
undetectable		 2vctD-4dooA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.39A 3adsA-4dooA:
undetectable		 3adsA-4dooA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 11 ILE A 146
ILE A 160
GLY A 162
PHE A 134
GLY A 166
 DAO  A 301 ( 4.9A)
None
None
DAO  A 301 (-3.9A)
None
 1.09A 4ac9B-4dooA:
undetectable
4ac9C-4dooA:
undetectable		 4ac9B-4dooA:
23.85
4ac9C-4dooA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		4 / 8 VAL A  94
ARG A 142
VAL A  27
GLY A  46
 None
 1.01A 4mk4A-4dooA:
undetectable		 4mk4A-4dooA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 VAL A  54
ILE A  85
ILE A  70
LEU A  25
ILE A  89
 None
 1.09A 4pd4C-4dooA:
undetectable		 4pd4C-4dooA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 10 LEU A  25
ALA A 199
LEU A  80
MET A  81
GLY A 183
 None
 1.39A 5dx3A-4dooA:
undetectable		 5dx3A-4dooA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 ASP A  50
LEU A 196
ALA A 199
PHE A  76
LEU A  57
 None
 1.19A 5nd7B-4dooA:
undetectable		 5nd7B-4dooA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN
(Arabidopsis
thaliana) 		5 / 12 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.10A 5y2oA-4dooA:
undetectable		 5y2oA-4dooA:
18.05