SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 10 VAL A 490
LEU A 488
SER A 359
VAL A 362
MET A 549
 None
 1.43A 1fdwA-4dpgA:
undetectable		 1fdwA-4dpgA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 7 LEU A 258
GLY A 262
LEU A 264
TYR A 316
 None
 0.94A 1gtiA-4dpgA:
undetectable		 1gtiA-4dpgA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 7 LEU A 258
GLY A 262
LEU A 264
TYR A 316
 None
 0.95A 1gtiD-4dpgA:
undetectable		 1gtiD-4dpgA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 7 LEU A 258
GLY A 262
LEU A 264
TYR A 316
 None
 0.95A 1gtiE-4dpgA:
undetectable		 1gtiE-4dpgA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 11 ILE A 564
ALA A 555
PHE A 557
ILE A 551
MET A 549
 None
 1.26A 1uduA-4dpgA:
undetectable		 1uduA-4dpgA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 452
MET A 469
LEU A 482
LEU A 444
PHE A 489
 None
 1.44A 2oaxC-4dpgA:
undetectable		 2oaxC-4dpgA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 SER A 248
ASP A 552
ALA A 555
THR A 559
ILE A 246
 None
 1.07A 3a35A-4dpgA:
2.3		 3a35A-4dpgA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 SER A 248
ASP A 552
ALA A 555
THR A 559
ILE A 246
 None
 1.11A 3a35B-4dpgA:
2.3		 3a35B-4dpgA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 SER A 248
ASP A 552
ALA A 555
THR A 559
ILE A 246
 None
 1.11A 3a3bA-4dpgA:
2.5		 3a3bA-4dpgA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 GLU A 317
HIS A 304
THR A 268
 None
 0.76A 3hkuA-4dpgA:
undetectable		 3hkuA-4dpgA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 5 GLY A 377
PRO A 375
ASN A 562
TYR A 373
 None
 0.99A 3u8qA-4dpgA:
undetectable		 3u8qA-4dpgA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 452
MET A 469
LEU A 482
LEU A 444
PHE A 489
 None
 1.39A 3vhuA-4dpgA:
undetectable		 3vhuA-4dpgA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 5 VAL A 358
ILE A 394
MET A 351
ILE A 462
 None
 0.64A 4c8bA-4dpgA:
undetectable		 4c8bA-4dpgA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 ARG A 241
GLY A 130
LEU A 206
SER A 207
VAL A 101
 None
 0.98A 4htfA-4dpgA:
undetectable		 4htfA-4dpgA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_B_SAMB301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 ARG A 241
GLY A 130
LEU A 206
SER A 207
VAL A 101
 None
 0.97A 4htfB-4dpgA:
undetectable		 4htfB-4dpgA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 8 ARG A 323
PHE A 335
GLY A 548
THR A 337
 APC  A 602 (-3.1A)
APC  A 602 (-3.8A)
LYS  A 601 ( 4.0A)
None
 0.98A 4k87A-4dpgA:
11.3		 4k87A-4dpgA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 6 ARG A 323
GLU A 494
ARG A 485
GLU A 487
 APC  A 602 (-3.1A)
MG  A 603 ( 3.4A)
None
MG  A 603 (-3.4A)
 1.32A 4kr3A-4dpgA:
13.4		 4kr3A-4dpgA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		3 / 3 ASP A 238
LEU A 213
ARG A 178
 None
 0.74A 5e8qA-4dpgA:
undetectable		 5e8qA-4dpgA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 7 GLY A 326
GLU A 325
ASP A 328
ASN A 332
 None
APC  A 602 ( 4.7A)
None
None
 1.02A 5n5dB-4dpgA:
undetectable		 5n5dB-4dpgA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W8A_A_SAMA300_0
(AUTOINDUCER SYNTHASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		5 / 12 LEU A 569
SER A 248
ILE A 246
GLU A 566
THR A 559
 None
 1.43A 5w8aA-4dpgA:
undetectable		 5w8aA-4dpgA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		6 / 10 ARG A 323
GLU A 325
HIS A 331
PHE A 335
GLY A 550
ILE A 564
 APC  A 602 (-3.1A)
APC  A 602 ( 4.7A)
APC  A 602 (-4.2A)
APC  A 602 (-3.8A)
APC  A 602 (-3.4A)
None
 0.89A 6bniA-4dpgA:
51.4		 6bniA-4dpgA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		6 / 10 ARG A 323
PHE A 335
GLU A 494
GLY A 550
ARG A 553
ILE A 564
 APC  A 602 (-3.1A)
APC  A 602 (-3.8A)
MG  A 603 ( 3.4A)
APC  A 602 (-3.4A)
APC  A 602 (-3.7A)
None
 1.06A 6bniA-4dpgA:
51.4		 6bniA-4dpgA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		6 / 10 ARG A 323
GLU A 325
HIS A 331
PHE A 335
GLY A 550
ILE A 564
 APC  A 602 (-3.1A)
APC  A 602 ( 4.7A)
APC  A 602 (-4.2A)
APC  A 602 (-3.8A)
APC  A 602 (-3.4A)
None
 0.84A 6bniB-4dpgA:
51.5		 6bniB-4dpgA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		6 / 10 ARG A 323
PHE A 335
GLU A 494
GLY A 550
ARG A 553
ILE A 564
 APC  A 602 (-3.1A)
APC  A 602 (-3.8A)
MG  A 603 ( 3.4A)
APC  A 602 (-3.4A)
APC  A 602 (-3.7A)
None
 1.05A 6bniB-4dpgA:
51.5		 6bniB-4dpgA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 4dpg LYSINE--TRNA LIGASE
(Homo
sapiens) 		4 / 4 LEU A 210
ASP A 180
PRO A 208
ARG A  80
 None
 1.42A 6fgdA-4dpgA:
undetectable		 6fgdA-4dpgA:
22.24