SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		3 / 3 GLU A  96
ILE A 147
ARG A 216
 None
 0.85A 1cd2A-4dpkA:
undetectable		 1cd2A-4dpkA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 8 ILE A  21
MET A  26
ASN A 335
GLY A  20
 None
 0.94A 1dzmA-4dpkA:
undetectable		 1dzmA-4dpkA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 8 SER A 331
LEU A 162
MET A 171
VAL A 233
 None
 0.99A 1fduB-4dpkA:
undetectable		 1fduB-4dpkA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 10 VAL A 233
PHE A 272
ASN A 127
ILE A 176
LEU A 218
 None
 1.25A 1fe2A-4dpkA:
undetectable		 1fe2A-4dpkA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 PHE A  99
PHE A 104
PRO A 105
THR A 150
ALA A  10
 None
 1.11A 1fm4A-4dpkA:
undetectable		 1fm4A-4dpkA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 8 SER A 234
LEU A 235
ILE A 211
LYS A 212
 None
 0.84A 1sbrA-4dpkA:
undetectable		 1sbrA-4dpkA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		3 / 3 MET A  26
ASN A 109
GLN A 156
 None
 1.06A 1xoqB-4dpkA:
undetectable		 1xoqB-4dpkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 7 THR A 283
PRO A 282
HIS A  30
GLY A 344
 None
 1.02A 2ddwB-4dpkA:
3.0		 2ddwB-4dpkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		6 / 12 GLY A 311
GLY A 344
GLY A 339
THR A 150
LEU A 122
ILE A 107
 None
 1.28A 2oxtB-4dpkA:
3.0		 2oxtB-4dpkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 5 SER A 331
GLY A 157
HIS A 240
ASP A 204
 None
 1.07A 2oxtB-4dpkA:
undetectable		 2oxtB-4dpkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		3 / 3 ARG A 338
GLN A 277
PRO A 285
 None
 0.81A 2qhfA-4dpkA:
undetectable		 2qhfA-4dpkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 10 ALA A 174
LEU A 162
LEU A 329
ILE A 327
PHE A 256
 None
 0.99A 2w9sD-4dpkA:
undetectable		 2w9sD-4dpkA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 10 ALA A 174
LEU A 162
LEU A 329
ILE A 327
PHE A 256
 None
 0.98A 2w9sF-4dpkA:
undetectable		 2w9sF-4dpkA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 6 MET A  26
ARG A 304
PRO A  61
GLY A  58
 None
 1.41A 3aqiA-4dpkA:
3.6		 3aqiA-4dpkA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 10 ILE A  82
ILE A 107
GLY A 343
PRO A 276
LEU A  27
 None
 0.88A 3elzB-4dpkA:
undetectable		 3elzB-4dpkA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 10 ILE A  82
ILE A 107
GLY A 343
PRO A 276
LEU A  27
 None
 0.98A 3elzC-4dpkA:
undetectable		 3elzC-4dpkA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		3 / 3 GLU A 349
HIS A  30
THR A 283
 None
 0.87A 3hkuA-4dpkA:
undetectable		 3hkuA-4dpkA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 122
GLY A 342
ILE A  33
LEU A 351
ILE A 357
 None
 1.04A 3ijdA-4dpkA:
undetectable		 3ijdA-4dpkA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 122
GLY A 342
ILE A  33
LEU A 351
ILE A 357
 None
 1.11A 3ijdB-4dpkA:
undetectable		 3ijdB-4dpkA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		3 / 3 PRO A 105
PHE A  84
ALA A 348
 None
 0.71A 3itaD-4dpkA:
undetectable		 3itaD-4dpkA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 8 TRP A  54
TRP A 305
HIS A 246
PRO A  61
 None
 1.04A 3v35A-4dpkA:
undetectable		 3v35A-4dpkA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 PRO A 120
LEU A 122
ILE A 107
ILE A 131
TYR A  32
 None
 1.41A 4a79A-4dpkA:
3.0		 4a79A-4dpkA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 6 PHE A 272
ALA A 164
LEU A 126
VAL A 221
 None
 0.88A 4dubA-4dpkA:
undetectable		 4dubA-4dpkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 6 PHE A 272
ALA A 164
LEU A 126
VAL A 221
 None
 0.96A 4dubB-4dpkA:
undetectable		 4dubB-4dpkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A 122
ALA A 284
ILE A 107
GLY A 343
GLY A 339
 None
 1.16A 4hfpB-4dpkA:
undetectable		 4hfpB-4dpkA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 5 VAL A 148
LEU A 351
ILE A 131
LEU A 133
 None
 0.84A 4mghA-4dpkA:
2.4		 4mghA-4dpkA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLY A 157
ILE A  12
GLY A  14
GLY A  17
THR A 154
 None
None
PO4  A 401 ( 4.8A)
PO4  A 402 (-3.1A)
PO4  A 403 (-3.7A)
 1.06A 5eqbA-4dpkA:
undetectable		 5eqbA-4dpkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN4_A_SC2A1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		4 / 4 HIS A 334
GLY A 247
ARG A 304
THR A 244
 None
 1.41A 5nn4A-4dpkA:
0.6		 5nn4A-4dpkA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 GLU A  63
GLU A  22
HIS A 334
THR A 283
GLY A 342
 None
 1.46A 5xioA-4dpkA:
3.8		 5xioA-4dpkA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 LEU A  13
GLY A  40
ILE A  69
ILE A  83
VAL A  80
 None
PO4  A 401 (-3.3A)
PO4  A 401 (-4.2A)
None
None
 1.01A 6emuA-4dpkA:
4.2		 6emuA-4dpkA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		3 / 3 HIS A 129
ASN A 127
LEU A 122
 None
 0.88A 6f7lB-4dpkA:
4.7		 6f7lB-4dpkA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4dpk MALONYL-COA/SUCCINYL
-COA REDUCTASE
(Sulfurisphaera
tokodaii) 		5 / 12 PRO A  74
ILE A  83
LEU A 351
GLY A 145
ILE A 147
 None
 1.04A 6qxsB-4dpkA:
undetectable		 6qxsB-4dpkA:
22.14