SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 LYS A  73
THR A  74
GLY A 106
LEU A 122
 None
 0.77A 1aegA-4dppA:
undetectable		 1aegA-4dppA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 PHE A 296
LEU A 291
VAL A 268
VAL A 263
 None
 1.11A 1e7aB-4dppA:
undetectable		 1e7aB-4dppA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 VAL A 136
GLY A 138
THR A 152
THR A 140
ILE A 123
 None
 1.21A 1gtnL-4dppA:
undetectable
1gtnM-4dppA:
undetectable		 1gtnL-4dppA:
13.95
1gtnM-4dppA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 VAL A 337
LEU A 336
ALA A 307
LEU A 311
 None
 0.82A 1pthA-4dppA:
undetectable		 1pthA-4dppA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 VAL A 337
LEU A 336
ALA A 307
LEU A 311
 None
 0.82A 1pthB-4dppA:
undetectable		 1pthB-4dppA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ASP A  83
ALA A  86
ASP A  89
GLY A 312
VAL A 317
 None
 1.14A 1sduB-4dppA:
undetectable		 1sduB-4dppA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ASP A  83
ALA A  86
ASP A  89
PRO A 316
VAL A 317
 None
 0.75A 2avoB-4dppA:
undetectable		 2avoB-4dppA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ASN A 139
GLY A 141
PHE A 182
ALA A 163
THR A 191
 None
 0.99A 2axnA-4dppA:
undetectable		 2axnA-4dppA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 PHE A 130
ILE A  93
LEU A 308
ALA A  99
ASP A  83
 None
 1.26A 2iyfB-4dppA:
undetectable		 2iyfB-4dppA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 VAL A 127
THR A 126
VAL A 104
GLY A 138
 None
 1.13A 2p2fB-4dppA:
undetectable		 2p2fB-4dppA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 ASP A  83
ALA A  86
ASP A  89
GLY A 312
VAL A 317
 None
 1.04A 2qhcA-4dppA:
undetectable		 2qhcA-4dppA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_2
(PROTEASE RETROPEPSIN)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ASP A  83
ALA A  86
ASP A  89
GLY A 312
VAL A 317
 None
 0.96A 2qhcB-4dppA:
undetectable		 2qhcB-4dppA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 308
PRO A 301
THR A 108
GLY A 109
GLY A 105
 None
 1.12A 2uvnA-4dppA:
undetectable		 2uvnA-4dppA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 MET A 292
PRO A 290
ASN A 285
LEU A 275
 None
 1.01A 2wekA-4dppA:
0.8		 2wekA-4dppA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 MET A 292
PRO A 290
ASN A 285
LEU A 275
 None
 1.05A 2wekB-4dppA:
2.1		 2wekB-4dppA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ASP A  83
ALA A  86
ASP A  89
GLY A 312
VAL A 317
 None
 1.06A 2z54A-4dppA:
undetectable		 2z54A-4dppA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ASP A 356
PHE A 359
LEU A 361
 None
 0.67A 2zi9A-4dppA:
undetectable		 2zi9A-4dppA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 9 ASP A  83
ALA A  86
ASP A  89
GLY A 312
VAL A 317
 None
 1.15A 3em4B-4dppA:
undetectable		 3em4B-4dppA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 ASP A  83
ALA A  86
ASP A  89
GLY A 312
VAL A 317
 None
 0.99A 4dqeB-4dppA:
undetectable		 4dqeB-4dppA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ILE A 261
MET A 276
ARG A  67
 None
 0.75A 4lnwA-4dppA:
undetectable		 4lnwA-4dppA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ILE A 261
MET A 276
ARG A  67
 None
 0.75A 4lnxA-4dppA:
undetectable		 4lnxA-4dppA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 ILE A 179
ILE A 209
SER A 213
LEU A 186
 None
 0.89A 4m51A-4dppA:
6.7		 4m51A-4dppA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ALA A  65
ALA A 162
ILE A 192
ALA A 219
ILE A 137
 None
 0.92A 4o2bD-4dppA:
3.1		 4o2bD-4dppA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 337
LEU A 336
LEU A 325
ALA A 307
LEU A 311
 None
 1.07A 4otyA-4dppA:
undetectable		 4otyA-4dppA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 337
LEU A 336
LEU A 325
ALA A 307
LEU A 311
 None
 1.05A 4otyB-4dppA:
undetectable		 4otyB-4dppA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 THR A  60
THR A 152
HIS A 165
ASN A 215
 None
 1.39A 4pgfB-4dppA:
undetectable		 4pgfB-4dppA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 LEU A 291
LEU A 295
ASN A 266
VAL A 346
LEU A  90
 None
None
None
NA  A 401 (-4.8A)
None
 1.13A 4po0A-4dppA:
undetectable		 4po0A-4dppA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 337
LEU A 336
LEU A 325
ALA A 307
LEU A 311
 None
 1.06A 4rrwD-4dppA:
undetectable		 4rrwD-4dppA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 337
LEU A 336
LEU A 325
ALA A 307
LEU A 311
 None
 1.06A 4rrzD-4dppA:
undetectable		 4rrzD-4dppA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ILE A 134
VAL A 102
PHE A  82
CYH A 129
 None
 1.12A 4rzvA-4dppA:
undetectable		 4rzvA-4dppA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 PRO A 269
TYR A  87
THR A 108
ASN A 300
ILE A  72
 None
 1.44A 4xe0A-4dppA:
undetectable		 4xe0A-4dppA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LYS A  73
GLU A 110
GLY A 105
GLY A 106
 None
 1.04A 5a06D-4dppA:
2.5		 5a06D-4dppA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 4dpp DIHYDRODIPICOLINATE
SYNTHASE 2,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 HIS A 165
HIS A 181
VAL A 185
ALA A 148
 None
 1.29A 5i3bB-4dppA:
undetectable		 5i3bB-4dppA:
21.89