SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dpy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 8 SER A 143
SER A  33
ASN A  31
LYS A  21
 None
2P0  A 401 ( 4.8A)
None
2P0  A 401 (-2.6A)
 1.22A 1hwiB-4dpyA:
3.3		 1hwiB-4dpyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 8 SER A 143
SER A  33
ASN A  31
LYS A  21
 None
2P0  A 401 ( 4.8A)
None
2P0  A 401 (-2.6A)
 1.22A 1hwkA-4dpyA:
undetectable		 1hwkA-4dpyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 8 SER A 143
SER A  33
ASN A  31
LYS A  21
 None
2P0  A 401 ( 4.8A)
None
2P0  A 401 (-2.6A)
 1.25A 1hwkC-4dpyA:
3.3		 1hwkC-4dpyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 8 SER A 143
SER A  33
ASN A  31
LYS A  21
 None
2P0  A 401 ( 4.8A)
None
2P0  A 401 (-2.6A)
 1.26A 1hwkD-4dpyA:
3.4		 1hwkD-4dpyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 6 LEU A 176
TRP A 172
PHE A 150
VAL A  36
 None
 1.29A 1ibgH-4dpyA:
undetectable		 1ibgH-4dpyA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 7 SER A 132
ALA A 142
SER A 162
ALA A 164
 None
 0.85A 1k5qA-4dpyA:
undetectable
1k5qB-4dpyA:
undetectable		 1k5qA-4dpyA:
22.39
1k5qB-4dpyA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 12 LEU A 176
SER A 177
VAL A  36
GLY A 149
SER A 320
 None
 1.06A 1pxxC-4dpyA:
undetectable		 1pxxC-4dpyA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 11 ILE A 146
ALA A 116
ALA A 115
LEU A 114
ALA A   7
 None
 1.09A 2aclE-4dpyA:
undetectable		 2aclE-4dpyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 12 ARG A   8
THR A  43
ASP A  56
ILE A  73
LEU A 114
 None
 1.36A 3iv6C-4dpyA:
undetectable		 3iv6C-4dpyA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 11 LEU A 122
LEU A 134
VAL A  47
GLY A   5
ALA A 117
 None
 1.21A 3pghB-4dpyA:
undetectable		 3pghB-4dpyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		3 / 3 LYS A 295
GLU A 293
TRP A 172
 None
 0.93A 3v4tH-4dpyA:
undetectable		 3v4tH-4dpyA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 8 TYR A 279
VAL A 290
ILE A 179
GLU A 269
 None
 0.92A 4a97G-4dpyA:
2.2		 4a97G-4dpyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 7 TYR A 279
VAL A 290
ILE A 179
GLU A 269
 None
 0.95A 4a97H-4dpyA:
undetectable		 4a97H-4dpyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 8 ILE A  92
ASP A  56
ILE A  73
SER A 141
GLY A 138
 None
None
None
2P0  A 401 (-2.7A)
None
 1.45A 4acaC-4dpyA:
undetectable		 4acaC-4dpyA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 8 ASN A  12
VAL A 323
ILE A 146
SER A 109
 None
 1.02A 4eyzA-4dpyA:
undetectable		 4eyzA-4dpyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 11 GLY A 149
GLY A 148
GLY A 322
ALA A 151
HIS A 165
 None
 1.18A 4l8fB-4dpyA:
undetectable		 4l8fB-4dpyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 12 LEU A 176
SER A 177
VAL A  36
GLY A 149
SER A 320
 None
 1.08A 4otyB-4dpyA:
undetectable		 4otyB-4dpyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 12 LEU A 176
SER A 177
VAL A  36
GLY A 149
SER A 320
 None
 0.99A 4rrwD-4dpyA:
undetectable		 4rrwD-4dpyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 12 LEU A 176
SER A 177
VAL A  36
GLY A 149
SER A 320
 None
 0.99A 4rrzD-4dpyA:
undetectable		 4rrzD-4dpyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 8 ALA A 105
ALA A 142
SER A 145
ALA A 110
 None
 0.66A 4twdF-4dpyA:
0.9
4twdG-4dpyA:
1.3
4twdH-4dpyA:
undetectable
4twdI-4dpyA:
undetectable
4twdJ-4dpyA:
undetectable		 4twdF-4dpyA:
21.63
4twdG-4dpyA:
21.63
4twdH-4dpyA:
21.63
4twdI-4dpyA:
21.63
4twdJ-4dpyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 8 ALA A 105
ALA A 142
SER A 145
ALA A 110
 None
 0.69A 4twdF-4dpyA:
0.9
4twdG-4dpyA:
1.3
4twdH-4dpyA:
undetectable
4twdI-4dpyA:
undetectable
4twdJ-4dpyA:
undetectable		 4twdF-4dpyA:
21.63
4twdG-4dpyA:
21.63
4twdH-4dpyA:
21.63
4twdI-4dpyA:
21.63
4twdJ-4dpyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		4 / 8 ALA A 142
SER A 145
ALA A 110
ALA A 105
 None
 0.70A 4twdF-4dpyA:
0.9
4twdG-4dpyA:
1.3
4twdH-4dpyA:
undetectable
4twdI-4dpyA:
undetectable
4twdJ-4dpyA:
undetectable		 4twdF-4dpyA:
21.63
4twdG-4dpyA:
21.63
4twdH-4dpyA:
21.63
4twdI-4dpyA:
21.63
4twdJ-4dpyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		3 / 3 LEU A 134
ARG A 137
ARG A 133
 None
 0.87A 4yiaB-4dpyA:
undetectable		 4yiaB-4dpyA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 11 SER A  35
SER A 132
LEU A 160
ASN A  32
GLY A 166
 None
 1.38A 4zjqA-4dpyA:
4.5		 4zjqA-4dpyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 10 GLY A 322
ALA A   7
VAL A 323
GLU A 324
ILE A 146
 None
 1.20A 5i3cB-4dpyA:
undetectable		 5i3cB-4dpyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 12 LEU A 217
HIS A 165
ALA A 164
SER A 132
GLY A 149
 None
 1.13A 5syeB-4dpyA:
undetectable		 5syeB-4dpyA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 10 SER A 132
LEU A  34
SER A  35
ILE A 167
GLY A 166
 None
 1.48A 6dlzA-4dpyA:
undetectable
6dlzD-4dpyA:
2.1		 6dlzA-4dpyA:
14.63
6dlzD-4dpyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 10 ILE A 167
GLY A 166
SER A 132
LEU A  34
SER A  35
 None
 1.48A 6dlzB-4dpyA:
undetectable
6dlzC-4dpyA:
undetectable		 6dlzB-4dpyA:
14.63
6dlzC-4dpyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 10 SER A 132
LEU A  34
SER A  35
ILE A 167
GLY A 166
 None
 1.48A 6dm1A-4dpyA:
undetectable
6dm1D-4dpyA:
2.1		 6dm1A-4dpyA:
14.63
6dm1D-4dpyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4dpy MEVALONATE
DIPHOSPHATE
DECARBOXYLASE
(Staphylococcus
epidermidis) 		5 / 10 ILE A 167
GLY A 166
SER A 132
LEU A  34
SER A  35
 None
 1.48A 6dm1B-4dpyA:
2.1
6dm1C-4dpyA:
undetectable		 6dm1B-4dpyA:
14.63
6dm1C-4dpyA:
14.63