SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 6 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 1.08A 3ablP-4dpzX:
undetectable
3ablW-4dpzX:
undetectable		 3ablP-4dpzX:
18.93
3ablW-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 7 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.99A 3ag2P-4dpzX:
undetectable
3ag2W-4dpzX:
undetectable		 3ag2P-4dpzX:
18.93
3ag2W-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 7 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.95A 3x2qC-4dpzX:
undetectable
3x2qJ-4dpzX:
undetectable		 3x2qC-4dpzX:
18.93
3x2qJ-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 7 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.98A 3x2qP-4dpzX:
undetectable
3x2qW-4dpzX:
undetectable		 3x2qP-4dpzX:
18.93
3x2qW-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 6 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.94A 5z84P-4dpzX:
undetectable
5z84W-4dpzX:
undetectable		 5z84P-4dpzX:
18.93
5z84W-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 7 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.92A 5z85C-4dpzX:
undetectable
5z85J-4dpzX:
undetectable		 5z85C-4dpzX:
18.93
5z85J-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 6 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.96A 5z85P-4dpzX:
undetectable
5z85W-4dpzX:
undetectable		 5z85P-4dpzX:
18.93
5z85W-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 6 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.91A 5z86C-4dpzX:
undetectable
5z86J-4dpzX:
undetectable		 5z86C-4dpzX:
18.93
5z86J-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 6 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.96A 5z86P-4dpzX:
undetectable
5z86W-4dpzX:
undetectable		 5z86P-4dpzX:
18.93
5z86W-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 7 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.93A 5zcoC-4dpzX:
undetectable
5zcoJ-4dpzX:
undetectable		 5zcoC-4dpzX:
18.93
5zcoJ-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 6 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.99A 5zcoP-4dpzX:
undetectable
5zcoW-4dpzX:
undetectable		 5zcoP-4dpzX:
18.93
5zcoW-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 6 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.91A 5zcpC-4dpzX:
undetectable
5zcpJ-4dpzX:
undetectable		 5zcpC-4dpzX:
18.93
5zcpJ-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 6 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.95A 5zcpP-4dpzX:
undetectable
5zcpW-4dpzX:
undetectable		 5zcpP-4dpzX:
18.93
5zcpW-4dpzX:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dpz HRAS-LIKE SUPPRESSOR
2
(Homo
sapiens) 		4 / 7 ARG X2095
GLN X2102
PHE X2116
LEU X2120
 None
 0.91A 5zcqP-4dpzX:
undetectable
5zcqW-4dpzX:
undetectable		 5zcqP-4dpzX:
18.93
5zcqW-4dpzX:
17.99