SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.93A 1drbB-4dq6A:
undetectable		 1drbB-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.97A 1ra2A-4dq6A:
undetectable		 1ra2A-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.93A 1ra8A-4dq6A:
undetectable		 1ra8A-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.95A 1rb2A-4dq6A:
undetectable		 1rb2A-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.92A 1rd7A-4dq6A:
undetectable		 1rd7A-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		4 / 5 ILE A 198
ILE A 155
ILE A 114
LEU A 183
 None
 0.83A 1zgyA-4dq6A:
undetectable		 1zgyA-4dq6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 11 HIS A 171
VAL A 120
TYR A 121
ASP A 200
LEU A 167
 None
None
PLP  A 401 (-3.5A)
PLP  A 401 (-2.8A)
None
 1.21A 2a5hA-4dq6A:
undetectable		 2a5hA-4dq6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_B_SAMB417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 HIS A 171
VAL A 120
TYR A 121
ASP A 200
LEU A 167
 None
None
PLP  A 401 (-3.5A)
PLP  A 401 (-2.8A)
None
 1.22A 2a5hB-4dq6A:
undetectable		 2a5hB-4dq6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 HIS A 171
VAL A 120
TYR A 121
ASP A 200
LEU A 167
 None
None
PLP  A 401 (-3.5A)
PLP  A 401 (-2.8A)
None
 1.23A 2a5hC-4dq6A:
undetectable		 2a5hC-4dq6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 HIS A 171
VAL A 120
TYR A 121
ASP A 200
LEU A 167
 None
None
PLP  A 401 (-3.5A)
PLP  A 401 (-2.8A)
None
 1.22A 2a5hD-4dq6A:
undetectable		 2a5hD-4dq6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.96A 2d0kB-4dq6A:
undetectable		 2d0kB-4dq6A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		4 / 7 ASP A 259
TYR A  69
ILE A  73
ASN A  70
 None
 1.06A 3avpA-4dq6A:
undetectable		 3avpA-4dq6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		4 / 8 SER A 356
ASN A 352
ASN A 355
TRP A 326
 None
 1.28A 3n62A-4dq6A:
undetectable		 3n62A-4dq6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		4 / 8 SER A 356
ASN A 352
ASN A 355
TRP A 326
 None
 1.33A 3n66B-4dq6A:
undetectable		 3n66B-4dq6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 11 ILE A 116
ILE A 104
VAL A 128
PHE A 124
VAL A 127
 None
 1.23A 3rf4A-4dq6A:
undetectable
3rf4B-4dq6A:
undetectable		 3rf4A-4dq6A:
13.78
3rf4B-4dq6A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 11 ILE A 116
ILE A 104
VAL A 128
PHE A 124
VAL A 127
 None
 1.26A 3rf4B-4dq6A:
undetectable
3rf4C-4dq6A:
undetectable		 3rf4B-4dq6A:
13.78
3rf4C-4dq6A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.95A 4ej1A-4dq6A:
undetectable		 4ej1A-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.99A 4i13A-4dq6A:
undetectable		 4i13A-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		4 / 7 SER A 356
ASN A 352
ASN A 355
TRP A 326
 None
 1.30A 4kcnB-4dq6A:
undetectable		 4kcnB-4dq6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 1.05A 4kjjA-4dq6A:
undetectable		 4kjjA-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.94A 4kjkA-4dq6A:
undetectable		 4kjkA-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		6 / 12 ILE A 387
PHE A 329
ILE A 367
ARG A 366
LEU A 351
ILE A 383
 None
 1.44A 4kjlA-4dq6A:
undetectable		 4kjlA-4dq6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 1.01A 4p3qA-4dq6A:
undetectable		 4p3qA-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 1.02A 4p3rA-4dq6A:
undetectable		 4p3rA-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 LEU A 351
ILE A 387
ILE A 367
ALA A 379
ILE A 307
 None
 1.06A 4rp8C-4dq6A:
undetectable		 4rp8C-4dq6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.88A 4x5iA-4dq6A:
undetectable		 4x5iA-4dq6A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		4 / 5 LEU A 167
PHE A 124
ILE A 198
ILE A 100
 None
 0.89A 5dzk4-4dq6A:
undetectable
5dzkg-4dq6A:
undetectable
5dzkm-4dq6A:
undetectable
5dzkn-4dq6A:
undetectable		 5dzk4-4dq6A:
5.71
5dzkg-4dq6A:
19.49
5dzkm-4dq6A:
18.95
5dzkn-4dq6A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.96A 5eajA-4dq6A:
undetectable		 5eajA-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.98A 5ujxA-4dq6A:
undetectable		 5ujxA-4dq6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		4 / 8 SER A 356
ASN A 352
ASN A 355
TRP A 326
 None
 1.31A 5vuoB-4dq6A:
undetectable		 5vuoB-4dq6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.99A 5z6jA-4dq6A:
undetectable		 5z6jA-4dq6A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.98A 5z6kA-4dq6A:
undetectable		 5z6kA-4dq6A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		4 / 8 SER A 356
ASN A 352
ASN A 355
TRP A 326
 None
 1.34A 6auuB-4dq6A:
undetectable		 6auuB-4dq6A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4dq6 PUTATIVE PYRIDOXAL
PHOSPHATE-DEPENDENT
TRANSFERASE
(Clostridioides
difficile) 		5 / 12 ILE A 387
PHE A 329
ILE A 367
LEU A 351
ILE A 383
 None
 0.95A 7dfrA-4dq6A:
undetectable		 7dfrA-4dq6A:
18.09