SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 10 MET A 114
ALA A 106
LEU A  82
LEU A  81
ILE A  27
 None
 1.26A 1a52B-4dqdA:
undetectable		 1a52B-4dqdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 9 MET A 114
ALA A 106
LEU A  82
LEU A  81
ILE A  27
 None
 1.25A 1ereA-4dqdA:
undetectable		 1ereA-4dqdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 9 MET A 114
ALA A 106
LEU A  82
LEU A  81
ILE A  27
 None
 1.25A 1ereB-4dqdA:
undetectable		 1ereB-4dqdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 9 MET A 114
ALA A 106
LEU A  82
LEU A  81
ILE A  27
 None
 1.27A 1ereC-4dqdA:
undetectable		 1ereC-4dqdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 9 MET A 114
ALA A 106
LEU A  82
LEU A  81
ILE A  27
 None
 1.25A 1ereD-4dqdA:
undetectable		 1ereD-4dqdA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 5 SER A 199
LEU A 205
GLY A 202
ARG A 234
 None
None
GOL  A 403 (-3.5A)
None
 1.21A 2j2pA-4dqdA:
undetectable
2j2pB-4dqdA:
undetectable		 2j2pA-4dqdA:
19.83
2j2pB-4dqdA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.83A 2v2gA-4dqdA:
undetectable
2v2gB-4dqdA:
undetectable		 2v2gA-4dqdA:
21.25
2v2gB-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.87A 2v2gA-4dqdA:
undetectable
2v2gB-4dqdA:
undetectable		 2v2gA-4dqdA:
21.25
2v2gB-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.85A 2v2gC-4dqdA:
undetectable
2v2gD-4dqdA:
undetectable		 2v2gC-4dqdA:
21.25
2v2gD-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 7 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.87A 2v2gC-4dqdA:
undetectable
2v2gD-4dqdA:
undetectable		 2v2gC-4dqdA:
21.25
2v2gD-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.87A 2v32A-4dqdA:
undetectable
2v32B-4dqdA:
undetectable		 2v32A-4dqdA:
21.25
2v32B-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.87A 2v32A-4dqdA:
undetectable
2v32B-4dqdA:
undetectable		 2v32A-4dqdA:
21.25
2v32B-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.83A 2v32C-4dqdA:
undetectable
2v32D-4dqdA:
undetectable		 2v32C-4dqdA:
21.25
2v32D-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 THR A  96
PRO A  97
VAL A  98
SER A  99
 PPY  A 401 (-3.9A)
PPY  A 401 (-4.7A)
None
None
 0.86A 2v32C-4dqdA:
undetectable
2v32D-4dqdA:
undetectable		 2v32C-4dqdA:
21.25
2v32D-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 4 ALA A 265
TYR A 241
ALA A 146
TYR A 150
 None
 1.24A 2wlkA-4dqdA:
undetectable
2wlkB-4dqdA:
undetectable		 2wlkA-4dqdA:
21.20
2wlkB-4dqdA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 SER A 199
ARG A 232
THR A 201
VAL A 204
ILE A 162
 None
 1.28A 2xpvA-4dqdA:
undetectable		 2xpvA-4dqdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 5 ALA A  74
LEU A  81
GLY A  28
THR A  47
 None
 0.94A 3dl9A-4dqdA:
undetectable		 3dl9A-4dqdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 ASP A 213
ALA A 156
GLY A 184
THR A 188
 None
 0.83A 3el9A-4dqdA:
undetectable		 3el9A-4dqdA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 5 TYR A 292
ILE A  91
LEU A 308
PHE A 288
 None
 1.26A 3ls4L-4dqdA:
undetectable		 3ls4L-4dqdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 118
GLY A  37
ALA A 220
SER A  93
HIS A 244
 PPY  A 401 (-3.6A)
None
PPY  A 401 (-3.4A)
None
PPY  A 401 (-3.6A)
 1.18A 3mg02-4dqdA:
undetectable
3mg0V-4dqdA:
undetectable		 3mg02-4dqdA:
19.95
3mg0V-4dqdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		3 / 3 ALA A 220
VAL A 246
GLN A 242
 PPY  A 401 (-3.4A)
None
None
 0.70A 3of4B-4dqdA:
undetectable		 3of4B-4dqdA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 6 SER A 219
TYR A 193
VAL A 200
THR A 189
 None
 1.15A 3tneA-4dqdA:
undetectable		 3tneA-4dqdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 PHE A 379
ILE A 303
PHE A 264
GLY A 221
 None
 1.01A 4fgjA-4dqdA:
4.5
4fgjB-4dqdA:
undetectable		 4fgjA-4dqdA:
20.32
4fgjB-4dqdA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 6 ALA A  78
ASN A  77
ASP A  67
GLU A  68
 None
 0.92A 4g24A-4dqdA:
2.3		 4g24A-4dqdA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 5 GLY A 221
ALA A  39
PHE A 251
GLU A 250
 None
GOL  A 402 ( 3.8A)
None
PG4  A 405 ( 3.9A)
 1.04A 4m93B-4dqdA:
undetectable
4m93C-4dqdA:
undetectable		 4m93B-4dqdA:
20.78
4m93C-4dqdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 MET A 114
LEU A 102
ALA A 106
LEU A  82
LEU A  81
 None
 1.13A 4pxmA-4dqdA:
undetectable		 4pxmA-4dqdA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 5 GLY A  37
ALA A  38
GLY A 221
PRO A 223
 None
GOL  A 402 (-3.7A)
None
None
 0.93A 4u9uA-4dqdA:
6.0		 4u9uA-4dqdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 5 GLY A  37
ALA A  38
GLY A 221
PRO A 223
 None
GOL  A 402 (-3.7A)
None
None
 0.91A 4u9uB-4dqdA:
6.0		 4u9uB-4dqdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 4 GLY A 256
VAL A 225
PHE A 236
ILE A 240
 None
 1.06A 4xv2B-4dqdA:
undetectable		 4xv2B-4dqdA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 11 MET A 114
LEU A 102
ALA A 106
LEU A  82
LEU A  81
 None
 1.12A 5dxgB-4dqdA:
undetectable		 5dxgB-4dqdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 12 GLN A  44
LEU A  95
GLY A 221
TYR A 168
GLY A 245
 None
PPY  A 401 (-4.1A)
None
PPY  A 401 (-3.8A)
PPY  A 401 (-3.6A)
 1.25A 5e3iA-4dqdA:
4.0		 5e3iA-4dqdA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		6 / 12 MET A 114
LEU A 102
ALA A 106
LEU A  82
LEU A  81
ILE A  27
 None
 1.24A 5gtrA-4dqdA:
undetectable		 5gtrA-4dqdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 11 MET A 114
LEU A 102
ALA A 106
LEU A  82
LEU A  81
 None
 1.14A 5hyrB-4dqdA:
undetectable		 5hyrB-4dqdA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		4 / 8 ILE A  55
PRO A  52
ILE A  91
LEU A 323
 None
3PY  A 404 (-3.9A)
None
None
 1.01A 5ieoA-4dqdA:
undetectable		 5ieoA-4dqdA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR
(Rhodopseudomonas
palustris) 		5 / 10 MET A 114
LEU A 102
ALA A 106
LEU A  82
ILE A  27
 None
 1.20A 6cbzB-4dqdA:
undetectable		 6cbzB-4dqdA:
14.19