SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dqn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		5 / 12 ALA A 121
LEU A   5
LEU A  17
PRO A  18
THR A 119
 None
 1.15A 1jolB-4dqnA:
undetectable		 1jolB-4dqnA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 7 PHE A 226
ALA A 280
PHE A 304
PHE A 277
 None
 1.28A 1lqtA-4dqnA:
undetectable		 1lqtA-4dqnA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 7 PHE A 226
ALA A 280
PHE A 304
PHE A 277
 None
 1.29A 1lquA-4dqnA:
undetectable		 1lquA-4dqnA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 4 SER A 290
VAL A 310
PHE A 166
VAL A 221
 None
 1.43A 1o86A-4dqnA:
undetectable		 1o86A-4dqnA:
19.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		5 / 8 TYR A 124
ARG A 126
GLY A 284
THR A 285
ALA A 286
 None
 0.48A 2a1hA-4dqnA:
40.7
2a1hB-4dqnA:
40.8		 2a1hA-4dqnA:
32.19
2a1hB-4dqnA:
32.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		5 / 10 TYR A 124
ARG A 126
GLY A 284
THR A 285
ALA A 286
 None
 0.41A 2coiA-4dqnA:
40.1
2coiB-4dqnA:
40.3		 2coiA-4dqnA:
33.16
2coiB-4dqnA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		5 / 10 TYR A 124
ARG A 126
GLY A 284
THR A 285
ALA A 286
 None
 0.36A 2coiA-4dqnA:
40.1
2coiB-4dqnA:
40.3		 2coiA-4dqnA:
33.16
2coiB-4dqnA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		6 / 11 PHE A  57
TYR A 124
ARG A 126
GLY A 284
THR A 285
ALA A 286
 None
 0.45A 2cojA-4dqnA:
40.0
2cojB-4dqnA:
40.0		 2cojA-4dqnA:
33.16
2cojB-4dqnA:
33.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		5 / 9 TYR A 124
ARG A 126
GLY A 284
THR A 285
ALA A 286
 None
 0.49A 2cojA-4dqnA:
40.0
2cojB-4dqnA:
40.0		 2cojA-4dqnA:
33.16
2cojB-4dqnA:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		6 / 8 TYR A 124
ARG A 126
GLY A 284
THR A 285
ALA A 286
ALA A 287
 None
 0.34A 2ej3A-4dqnA:
33.0		 2ej3A-4dqnA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		8 / 10 PHE A  57
TYR A 124
ARG A 126
TYR A 189
GLY A 284
THR A 285
ALA A 286
ALA A 287
 None
 0.51A 2ej3B-4dqnA:
33.7		 2ej3B-4dqnA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		5 / 9 VAL A 135
GLY A 133
SER A  47
LEU A  50
SER A  44
 None
 1.42A 2j2pB-4dqnA:
undetectable
2j2pC-4dqnA:
undetectable		 2j2pB-4dqnA:
21.13
2j2pC-4dqnA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		6 / 12 SER A 242
ALA A 182
GLY A 181
ASN A 188
ALA A 176
GLY A 187
 None
 1.37A 2pkmA-4dqnA:
undetectable		 2pkmA-4dqnA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 6 PRO A 195
SER A 192
GLU A 220
TYR A 209
 None
 1.32A 2x7hA-4dqnA:
undetectable		 2x7hA-4dqnA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 6 ASN A  76
ILE A 100
GLU A  80
ASN A  78
 None
 1.34A 3kp6A-4dqnA:
undetectable
3kp6B-4dqnA:
undetectable		 3kp6A-4dqnA:
18.55
3kp6B-4dqnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		3 / 3 PRO A 163
SER A 306
ASN A 165
 None
 0.90A 3lslG-4dqnA:
undetectable		 3lslG-4dqnA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 5 VAL A 132
GLY A 133
TYR A 144
ASP A 142
 None
 1.44A 3w9tA-4dqnA:
undetectable		 3w9tA-4dqnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 5 VAL A 132
GLY A 133
TYR A 144
ASP A 142
 None
 1.45A 3w9tB-4dqnA:
undetectable		 3w9tB-4dqnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 5 VAL A 132
GLY A 133
TYR A 144
ASP A 142
 None
 1.45A 3w9tC-4dqnA:
undetectable		 3w9tC-4dqnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 5 VAL A 132
GLY A 133
TYR A 144
ASP A 142
 None
 1.45A 3w9tD-4dqnA:
undetectable		 3w9tD-4dqnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 5 VAL A 132
GLY A 133
TYR A 144
ASP A 142
 None
 1.44A 3w9tE-4dqnA:
undetectable		 3w9tE-4dqnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 5 VAL A 132
GLY A 133
TYR A 144
ASP A 142
 None
 1.44A 3w9tF-4dqnA:
undetectable		 3w9tF-4dqnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 5 VAL A 132
GLY A 133
TYR A 144
ASP A 142
 None
 1.44A 3w9tG-4dqnA:
undetectable		 3w9tG-4dqnA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F92_B_SANB2201_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		5 / 9 GLU A 219
TYR A 209
ASN A 188
GLY A 181
SER A 242
 None
 1.14A 4f92B-4dqnA:
0.0		 4f92B-4dqnA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 8 GLY A 131
GLY A  53
VAL A 185
GLU A  55
 None
 0.58A 4fgzB-4dqnA:
undetectable		 4fgzB-4dqnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 6 GLY A 181
ASN A 225
GLU A 220
MET A  91
 None
 1.24A 4g0vB-4dqnA:
undetectable		 4g0vB-4dqnA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		3 / 3 ARG A 126
GLU A  58
PHE A  99
 None
 0.76A 4kszA-4dqnA:
undetectable		 4kszA-4dqnA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		5 / 12 PHE A 149
PHE A  57
LEU A 244
THR A 248
GLY A 284
 None
 1.49A 4zjlA-4dqnA:
undetectable		 4zjlA-4dqnA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 4 GLU A 266
PRO A 238
ILE A 243
LEU A 239
 None
 1.30A 5m45A-4dqnA:
1.2		 5m45A-4dqnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 4 GLU A 266
PRO A 238
ILE A 243
LEU A 239
 None
 1.22A 5m45D-4dqnA:
undetectable		 5m45D-4dqnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 4 GLU A 266
PRO A 238
ILE A 243
LEU A 239
 None
 1.29A 5m45G-4dqnA:
undetectable		 5m45G-4dqnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 4 GLU A 266
PRO A 238
ILE A 243
LEU A 239
 None
 1.23A 5m45J-4dqnA:
undetectable		 5m45J-4dqnA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		4 / 5 PHE A 301
VAL A 221
PRO A 163
VAL A 303
 None
 1.34A 6ekzA-4dqnA:
undetectable		 6ekzA-4dqnA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE
(Streptococcus
mutans) 		3 / 3 ASP A 142
SER A  46
SER A  44
 None
 0.68A 6mxtA-4dqnA:
undetectable		 6mxtA-4dqnA:
22.36