SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dqv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 308
VAL A 337
THR A 415
ASP A 435
 None
 1.11A 1dz9A-4dqvA:
undetectable		 1dz9A-4dqvA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 5 ARG A  87
ALA A 125
ASP A 127
GLY A 134
 None
 1.15A 1e7cA-4dqvA:
undetectable		 1e7cA-4dqvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 10 ASN A 158
SER A 153
GLY A  65
ARG A  66
GLY A  59
 None
 1.43A 1ho5B-4dqvA:
undetectable		 1ho5B-4dqvA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 5 SER A 192
THR A 193
GLU A 236
GLY A 235
 None
 1.27A 1icrA-4dqvA:
undetectable
1icrB-4dqvA:
undetectable		 1icrA-4dqvA:
18.98
1icrB-4dqvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 236
GLY A 235
SER A 192
THR A 193
 None
 1.27A 1icrA-4dqvA:
undetectable
1icrB-4dqvA:
undetectable		 1icrA-4dqvA:
18.98
1icrB-4dqvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 5 SER A 192
THR A 193
GLU A 236
GLY A 235
 None
 1.27A 1icvC-4dqvA:
undetectable
1icvD-4dqvA:
undetectable		 1icvC-4dqvA:
18.98
1icvD-4dqvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 236
GLY A 235
SER A 192
THR A 193
 None
 1.27A 1icvC-4dqvA:
undetectable
1icvD-4dqvA:
undetectable		 1icvC-4dqvA:
18.98
1icvD-4dqvA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 236
GLY A 235
SER A 192
THR A 193
 None
 1.26A 1kqbA-4dqvA:
undetectable
1kqbB-4dqvA:
undetectable		 1kqbA-4dqvA:
17.51
1kqbB-4dqvA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 315
LYS A 426
VAL A 427
 None
 0.75A 1l2iA-4dqvA:
undetectable		 1l2iA-4dqvA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 SER A 215
ILE A 211
TYR A 335
VAL A 252
ALA A 251
 None
 1.08A 1tlsA-4dqvA:
undetectable		 1tlsA-4dqvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 SER A 215
ILE A 211
TYR A 335
VAL A 252
ALA A 251
 None
 1.10A 1tsnA-4dqvA:
undetectable		 1tsnA-4dqvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 236
TYR A 190
SER A 215
ASP A 195
 None
 1.27A 1vidA-4dqvA:
6.8		 1vidA-4dqvA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 236
TYR A 190
SER A 215
ASP A 195
 None
 1.26A 2cl5B-4dqvA:
6.3		 2cl5B-4dqvA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_E_H4BE1004_1
(HYPOTHETICAL PROTEIN
PH0634)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 11 TYR A 335
VAL A 422
HIS A 341
THR A 415
GLU A 207
 None
 1.36A 2dttD-4dqvA:
undetectable
2dttE-4dqvA:
undetectable		 2dttD-4dqvA:
15.35
2dttE-4dqvA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 151
PHE A 188
ILE A 179
LEU A 135
ASP A 127
 None
 1.17A 2iyfB-4dqvA:
5.9		 2iyfB-4dqvA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 214
GLU A 236
VAL A 237
PHE A 332
ARG A 254
 None
 1.21A 2no0B-4dqvA:
1.6		 2no0B-4dqvA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 8 ARG A  75
PRO A 437
VAL A 427
GLY A 428
 None
 0.77A 2qd3A-4dqvA:
undetectable		 2qd3A-4dqvA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 418
THR A 415
ALA A 413
ILE A 436
ASN A 339
 None
 1.12A 2rlcA-4dqvA:
undetectable		 2rlcA-4dqvA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 236
TYR A 190
SER A 215
ASP A 195
 None
 1.29A 2zvjA-4dqvA:
undetectable		 2zvjA-4dqvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 SER A 192
THR A 193
ASP A 210
ILE A 214
ASP A 195
 None
 1.34A 3iv6B-4dqvA:
6.9		 3iv6B-4dqvA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 228
SER A 153
PHE A 253
VAL A 337
ASN A 158
 None
 1.34A 3nbrA-4dqvA:
undetectable		 3nbrA-4dqvA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 228
SER A 153
PHE A 253
VAL A 337
ASN A 158
 None
 1.28A 3nhxA-4dqvA:
undetectable		 3nhxA-4dqvA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 228
SER A 153
PHE A 253
VAL A 337
ASN A 158
 None
 1.25A 3nuvA-4dqvA:
undetectable		 3nuvA-4dqvA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 240
ARG A 254
ASP A 208
 None
 0.84A 3wipG-4dqvA:
undetectable
3wipH-4dqvA:
undetectable		 3wipG-4dqvA:
18.31
3wipH-4dqvA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 166
GLY A 235
LEU A  28
VAL A 237
 None
 0.94A 4dubA-4dqvA:
undetectable		 4dubA-4dqvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 6 PHE A 166
GLY A 235
LEU A  28
VAL A 237
 None
 0.93A 4dubB-4dqvA:
undetectable		 4dubB-4dqvA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 12 SER A 215
ILE A 211
TYR A 335
VAL A 252
ALA A 251
 None
 1.03A 4foxD-4dqvA:
undetectable		 4foxD-4dqvA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		3 / 3 TYR A  67
ARG A  74
HIS A 112
 None
 0.94A 4fubA-4dqvA:
undetectable		 4fubA-4dqvA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 428
ASP A 435
PRO A 437
HIS A 341
 None
 1.18A 4lajA-4dqvA:
undetectable
4lajB-4dqvA:
undetectable		 4lajA-4dqvA:
21.30
4lajB-4dqvA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 11 ASP A  27
PRO A 168
VAL A 170
ALA A 171
PHE A 166
 None
 1.26A 4mmaA-4dqvA:
undetectable		 4mmaA-4dqvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 128
LYS A 232
ALA A 155
 None
 1.30A 4ot2A-4dqvA:
0.0		 4ot2A-4dqvA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 236
TYR A 190
SER A 215
ASP A 195
 None
 1.28A 5fhrA-4dqvA:
6.7		 5fhrA-4dqvA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_H_BO2H306_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 413
GLU A 207
ALA A 198
GLY A 197
ALA A 194
 None
 1.14A 5lf3H-4dqvA:
undetectable
5lf3I-4dqvA:
undetectable		 5lf3H-4dqvA:
20.25
5lf3I-4dqvA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 413
GLU A 207
ALA A 198
GLY A 197
ALA A 194
 None
 1.13A 5lf3V-4dqvA:
undetectable
5lf3W-4dqvA:
undetectable		 5lf3V-4dqvA:
20.25
5lf3W-4dqvA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		3 / 3 GLY A 256
THR A 193
ASN A 158
 None
 0.63A 5odiG-4dqvA:
5.3		 5odiG-4dqvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 335
PHE A 418
PHE A 312
VAL A 319
 None
 1.22A 6huoC-4dqvA:
undetectable
6huoD-4dqvA:
undetectable		 6huoC-4dqvA:
10.33
6huoD-4dqvA:
11.60