SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4drf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4drf METHYLTRANSFERASE
TYPE 12
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU B 179
LEU B 178
LEU B  52
ILE B  93
PHE B  29
 None
 1.29A 1fmlA-4drfB:
undetectable		 1fmlA-4drfB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4drf METHYLTRANSFERASE
TYPE 12
(Ruminiclostridiu
m
thermocellum) 		4 / 8 GLY B  98
THR B  99
ALA B 100
TYR B  40
 None
 0.81A 2a1hA-4drfB:
undetectable
2a1hB-4drfB:
undetectable		 2a1hA-4drfB:
20.83
2a1hB-4drfB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4drf METHYLTRANSFERASE
TYPE 12
(Ruminiclostridiu
m
thermocellum) 		5 / 10 GLY B  98
THR B  99
ALA B 100
TYR B  40
VAL B  50
 None
 0.92A 2coiA-4drfB:
undetectable
2coiB-4drfB:
undetectable		 2coiA-4drfB:
19.74
2coiB-4drfB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4drf METHYLTRANSFERASE
TYPE 12
(Ruminiclostridiu
m
thermocellum) 		5 / 10 TYR B  40
VAL B  50
GLY B  98
THR B  99
ALA B 100
 None
 0.91A 2coiA-4drfB:
undetectable
2coiB-4drfB:
undetectable		 2coiA-4drfB:
19.74
2coiB-4drfB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4drf METHYLTRANSFERASE
TYPE 12
(Ruminiclostridiu
m
thermocellum) 		5 / 11 GLY B  98
THR B  99
ALA B 100
TYR B  40
VAL B  50
 None
 0.93A 2cojA-4drfB:
undetectable
2cojB-4drfB:
undetectable		 2cojA-4drfB:
19.74
2cojB-4drfB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4drf METHYLTRANSFERASE
TYPE 12
(Ruminiclostridiu
m
thermocellum) 		5 / 9 TYR B  40
VAL B  50
GLY B  98
THR B  99
ALA B 100
 None
 0.86A 2cojA-4drfB:
undetectable
2cojB-4drfB:
undetectable		 2cojA-4drfB:
19.74
2cojB-4drfB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 4drf METHYLTRANSFERASE
TYPE 12
(Ruminiclostridiu
m
thermocellum) 		5 / 9 LEU B   3
VAL B 167
ILE B 134
ALA B 120
ILE B 122
 None
 0.92A 3el0B-4drfB:
undetectable		 3el0B-4drfB:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4drf METHYLTRANSFERASE
TYPE 12
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU B  52
PHE B  39
ILE B   2
 None
 0.75A 5dzk1-4drfB:
undetectable
5dzkF-4drfB:
undetectable
5dzkM-4drfB:
undetectable		 5dzk1-4drfB:
10.53
5dzkF-4drfB:
22.45
5dzkM-4drfB:
23.27