SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4drr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GMK_C_DVAC8_0 (GRAMICIDIN A)	4drr	OUTER CAPSID PROTEIN VP4 (Rotavirus sp.)	3 / 4	VAL A 199 TRP A 102 TRP A 167	None	1.35A	1gmkC-4drrA: undetectable 1gmkD-4drrA: undetectable	1gmkC-4drrA: 8.41 1gmkD-4drrA: 8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LW1_H_ADNH401_1 (MITOGEN-ACTIVATED PROTEIN KINASE 8)	4drr	OUTER CAPSID PROTEIN VP4 (Rotavirus sp.)	5 / 9	GLY A 90 VAL A 106 ALA A 104 VAL A 126 LEU A 128	None	0.86A	5lw1H-4drrA: undetectable	5lw1H-4drrA: 17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N8J_E_DVAE7_0 (GLY-DTY-GLY-DLE-DAL- DSG-DVA-DAS-DGL-DSN- DSN-GLY STREPTAVIDIN)	4drr	OUTER CAPSID PROTEIN VP4 (Rotavirus sp.)	3 / 3	TYR A 175 SER A 187 TRP A 81	None	0.74A	5n8jB-4drrA: undetectable	5n8jB-4drrA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N8J_O_DVAO7_0 (GLY-DTY-GLY-DLE-DAL- DSG-DVA-DAS-DGL-DSN- DSN-GLY STREPTAVIDIN)	4drr	OUTER CAPSID PROTEIN VP4 (Rotavirus sp.)	3 / 3	TYR A 175 SER A 187 TRP A 81	None	0.75A	5n8jA-4drrA: undetectable	5n8jA-4drrA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N8J_P_DVAP5_0 (GLY-DTY-GLY-DLE-DAL- DSG-DVA-DAS-DGL-DSN- DSN-GLY STREPTAVIDIN)	4drr	OUTER CAPSID PROTEIN VP4 (Rotavirus sp.)	3 / 3	TYR A 175 SER A 187 TRP A 81	None	0.73A	5n8jD-4drrA: undetectable	5n8jD-4drrA: 21.51

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GMK_C_DVAC8_0","GRAMICIDIN A","4drr","OUTER CAPSID PROTEIN VP4","Rotavirus sp.",3,"VAL A 199;TRP A 102;TRP A 167","None","1.35A","1gmkC-4drrA:undetectable;1gmkD-4drrA:undetectable","1gmkC-4drrA:8.41;1gmkD-4drrA:8.41"],["5LW1_H_ADNH401_1","MITOGEN-ACTIVATED PROTEIN KINASE 8","4drr","OUTER CAPSID PROTEIN VP4","Rotavirus sp.",5,"GLY A  90;VAL A 106;ALA A 104;VAL A 126;LEU A 128","None","0.86A","5lw1H-4drrA:undetectable","5lw1H-4drrA:17.79"],["5N8J_E_DVAE7_0","GLY-DTY-GLY-DLE-DAL-DSG-DVA-DAS-DGL-DSN-DSN-GLY;STREPTAVIDIN","4drr","OUTER CAPSID PROTEIN VP4","Rotavirus sp.",3,"TYR A 175;SER A 187;TRP A  81","None","0.74A","5n8jB-4drrA:undetectable","5n8jB-4drrA:21.51"],["5N8J_O_DVAO7_0","GLY-DTY-GLY-DLE-DAL-DSG-DVA-DAS-DGL-DSN-DSN-GLY;STREPTAVIDIN","4drr","OUTER CAPSID PROTEIN VP4","Rotavirus sp.",3,"TYR A 175;SER A 187;TRP A  81","None","0.75A","5n8jA-4drrA:undetectable","5n8jA-4drrA:21.51"],["5N8J_P_DVAP5_0","GLY-DTY-GLY-DLE-DAL-DSG-DVA-DAS-DGL-DSN-DSN-GLY;STREPTAVIDIN","4drr","OUTER CAPSID PROTEIN VP4","Rotavirus sp.",3,"TYR A 175;SER A 187;TRP A  81","None","0.73A","5n8jD-4drrA:undetectable","5n8jD-4drrA:21.51"]]