SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4drs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		5 / 12 GLU A 272
ASN A 273
ILE A 115
GLY A 112
SER A 236
 GOL  A 603 (-3.9A)
None
None
None
GOL  A 603 ( 4.8A)
 1.42A 1q8jA-4drsA:
13.5		 1q8jA-4drsA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		3 / 3 TYR A 391
ARG A  44
GLN A  47
 None
 1.03A 1tw4A-4drsA:
undetectable		 1tw4A-4drsA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		4 / 6 ILE A 271
VAL A 292
ILE A 389
ASP A 354
 None
 0.65A 1uwhA-4drsA:
undetectable		 1uwhA-4drsA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		4 / 7 ARG A  93
LEU A  89
PHE A 224
LEU A 230
 ACT  A 607 (-4.1A)
ACT  A 607 ( 4.9A)
None
None
 1.02A 2eimP-4drsA:
undetectable
2eimW-4drsA:
undetectable		 2eimP-4drsA:
18.80
2eimW-4drsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		3 / 3 SER A  71
THR A 449
GLN A  43
 None
 0.85A 2fk8A-4drsA:
2.6		 2fk8A-4drsA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		4 / 8 SER A 282
ASN A 279
ILE A 283
ASP A 243
 None
 1.12A 2v57A-4drsA:
undetectable		 2v57A-4drsA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		4 / 8 SER A 282
ASN A 279
ILE A 283
ASP A 243
 None
 1.12A 2v57C-4drsA:
undetectable		 2v57C-4drsA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		4 / 7 HIS A 507
VAL A 506
VAL A 523
ALA A 503
 None
 0.91A 3kp6B-4drsA:
undetectable		 3kp6B-4drsA:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		8 / 10 THR A  51
PRO A  54
ARG A  74
ASN A  76
HIS A  79
GLY A  80
GLY A 363
ALA A 366
 ACT  A 605 ( 4.2A)
None
GOL  A 603 ( 3.6A)
GOL  A 603 ( 3.3A)
ACT  A 606 (-4.0A)
ACT  A 606 (-4.0A)
ACT  A 605 (-3.7A)
ACT  A 605 ( 4.0A)
 0.36A 3pp7B-4drsA:
56.3		 3pp7B-4drsA:
42.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		3 / 3 HIS A 399
SER A 419
GLU A 418
 None
 0.92A 3s8pA-4drsA:
undetectable		 3s8pA-4drsA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		5 / 12 GLU A 272
ASN A 273
ILE A 115
GLY A 112
SER A 236
 GOL  A 603 (-3.9A)
None
None
None
GOL  A 603 ( 4.8A)
 1.42A 4djfA-4drsA:
13.4		 4djfA-4drsA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		4 / 5 ILE A 149
LEU A 134
LYS A 135
ASN A 145
 None
 1.12A 4g19A-4drsA:
undetectable		 4g19A-4drsA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		5 / 12 ILE A 429
ALA A 452
ILE A 412
PRO A 409
ASN A 518
 None
 1.06A 4gh8B-4drsA:
undetectable		 4gh8B-4drsA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		5 / 12 ASN A 145
ILE A 149
GLY A 118
GLU A 197
GLU A 121
 None
 1.33A 4xt8A-4drsA:
2.4		 4xt8A-4drsA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		5 / 12 ALA A 327
SER A 333
THR A 341
GLU A 364
SER A 362
 None
None
None
None
GOL  A 603 ( 3.4A)
 1.19A 5hfjE-4drsA:
undetectable		 5hfjE-4drsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		4 / 6 ARG A  93
LEU A  89
PHE A 224
LEU A 230
 ACT  A 607 (-4.1A)
ACT  A 607 ( 4.9A)
None
None
 1.12A 5x19P-4drsA:
undetectable		 5x19P-4drsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		4 / 5 ARG A  93
LEU A  89
PHE A 224
LEU A 230
 ACT  A 607 (-4.1A)
ACT  A 607 ( 4.9A)
None
None
 1.13A 5x1bP-4drsA:
undetectable		 5x1bP-4drsA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4drs PYRUVATE KINASE
(Cryptosporidium
parvum) 		3 / 3 PHE A 224
ASP A 223
LYS A 227
 None
 0.82A 6awtD-4drsA:
undetectable		 6awtD-4drsA:
15.52