SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ds2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 LEU A  16
LEU A  50
PRO A  82
VAL A  84
 None
 1.17A 2dqyC-4ds2A:
undetectable		 2dqyC-4ds2A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 SER A 117
GLU A  18
ASP A  12
 None
 0.78A 2zthA-4ds2A:
undetectable		 2zthA-4ds2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 SER A 117
GLU A  18
ASP A  12
 None
 0.78A 3bwmA-4ds2A:
undetectable		 3bwmA-4ds2A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 SER A 117
GLU A  18
ASP A  12
 None
 0.77A 3bwyA-4ds2A:
undetectable		 3bwyA-4ds2A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 GLU A  98
GLY A  97
VAL A  95
GLY A 161
TYR A  91
 None
 1.27A 4fimA-4ds2A:
undetectable		 4fimA-4ds2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 TYR A  77
HIS A 115
ARG A   8
 None
 1.03A 4htfA-4ds2A:
undetectable		 4htfA-4ds2A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 SER A 117
GLU A  18
ASP A  12
 None
 0.77A 4xudA-4ds2A:
undetectable		 4xudA-4ds2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 PHE A 128
LYS A  53
GLY A  61
TYR A  60
 None
 1.25A 4yshB-4ds2A:
undetectable		 4yshB-4ds2A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 PHE A  73
HIS A 115
LEU A  16
PRO A  82
 None
 1.02A 5csyB-4ds2A:
undetectable		 5csyB-4ds2A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4ds2 UBIQUITIN-CONJUGATIN
G ENZYME E2,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 ASP A 137
ARG A 135
ARG A 144
GLN A 152
 None
 0.86A 6fbvD-4ds2A:
undetectable		 6fbvD-4ds2A:
8.58