SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ds3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 4ds3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 11 SER A  11
GLY A  14
SER A  15
LEU A  88
ASP A  39
 None
GOL  A 305 (-3.7A)
GOL  A 305 (-4.7A)
None
None
 1.42A 2c2bE-4ds3A:
undetectable
2c2bF-4ds3A:
2.7		 2c2bE-4ds3A:
18.05
2c2bF-4ds3A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 4ds3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 GLY A  14
SER A  15
ALA A  19
LEU A  20
PHE A  37
 GOL  A 305 (-3.7A)
GOL  A 305 (-4.7A)
None
None
None
 1.10A 2yvlA-4ds3A:
3.7		 2yvlA-4ds3A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 4ds3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 GLY A  14
SER A  15
ALA A  19
LEU A  20
PHE A  37
 GOL  A 305 (-3.7A)
GOL  A 305 (-4.7A)
None
None
None
 1.06A 2yvlC-4ds3A:
3.9		 2yvlC-4ds3A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ds3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 ALA A  24
ALA A  23
GLN A  25
VAL A 139
ILE A 110
 None
 0.89A 3e00A-4ds3A:
undetectable		 3e00A-4ds3A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ds3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 10 ALA A  24
ALA A  23
GLN A  25
VAL A 139
ILE A 110
 None
 0.87A 3falA-4ds3A:
undetectable		 3falA-4ds3A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4ds3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Brucella
melitensis) 		4 / 8 ILE A  85
ALA A  31
PHE A  29
ALA A  23
 None
 0.96A 3hrdA-4ds3A:
undetectable
3hrdB-4ds3A:
undetectable		 3hrdA-4ds3A:
18.24
3hrdB-4ds3A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 4ds3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 ILE A  85
ALA A  35
ALA A  24
PHE A 187
PRO A  30
 None
 1.07A 3jayA-4ds3A:
undetectable		 3jayA-4ds3A:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4ds3 PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Brucella
melitensis) 		5 / 12 ALA A  24
ALA A  23
GLN A  25
VAL A 139
ILE A 110
 None
 0.97A 3oapA-4ds3A:
undetectable		 3oapA-4ds3A:
24.62