SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 6 ASN A 375
LEU A 376
TRP A  92
PHE A 318
 None
 1.22A 1ru9H-4dshA:
undetectable
1ru9L-4dshA:
undetectable		 1ru9H-4dshA:
19.46
1ru9L-4dshA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 6 PHE A 144
PHE A 102
ASN A 105
ASN A 157
 None
None
None
UDP  A 501 (-2.7A)
 1.46A 1t9uA-4dshA:
2.4		 1t9uA-4dshA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 9 ALA A 328
LEU A 346
TRP A  97
PHE A 318
LEU A 310
 None
 1.34A 1y7iA-4dshA:
2.1		 1y7iA-4dshA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 8 VAL A 448
ASP A 446
THR A   6
PRO A   7
 None
 0.87A 1z2bB-4dshA:
2.6		 1z2bB-4dshA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 8 GLY A  18
GLY A  20
ALA A  22
ALA A  21
PHE A 438
 None
 1.19A 2ha4A-4dshA:
undetectable		 2ha4A-4dshA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 7 GLY A  18
GLY A  20
ALA A  22
ALA A  21
PHE A 438
 None
 1.14A 2ha4B-4dshA:
undetectable		 2ha4B-4dshA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 6 LEU A 268
VAL A  23
ILE A  11
MET A 414
 None
 1.14A 2hyyC-4dshA:
undetectable		 2hyyC-4dshA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 LEU A  35
GLY A  20
ALA A  21
GLY A 422
ILE A  11
 None
None
None
FDA  A 502 (-3.3A)
None
 0.91A 2ienA-4dshA:
undetectable		 2ienA-4dshA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 6 PRO A  42
GLY A  15
ILE A  11
GLY A  13
 None
FDA  A 502 (-3.2A)
None
FDA  A 502 (-3.3A)
 0.86A 2jkjA-4dshA:
undetectable		 2jkjA-4dshA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 6 PRO A  42
GLY A  15
ILE A  11
GLY A  13
 None
FDA  A 502 (-3.2A)
None
FDA  A 502 (-3.3A)
 0.86A 2jkjB-4dshA:
undetectable		 2jkjB-4dshA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 6 PRO A  42
GLY A  15
ILE A  11
GLY A  13
 None
FDA  A 502 (-3.2A)
None
FDA  A 502 (-3.3A)
 0.86A 2jkjC-4dshA:
undetectable		 2jkjC-4dshA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 372
GLY A 370
ALA A 328
LEU A 316
PHE A 318
 None
 1.12A 2oz7A-4dshA:
undetectable		 2oz7A-4dshA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		6 / 12 LEU A  35
GLY A  20
ALA A  21
ILE A   9
VAL A 448
ILE A  11
 None
 1.40A 2rkgA-4dshA:
undetectable		 2rkgA-4dshA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 7 ASP A  72
SER A  66
GLU A 443
ASP A 446
 None
 1.32A 3bc9A-4dshA:
undetectable		 3bc9A-4dshA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 297
GLY A 299
SER A 345
THR A 329
LYS A 311
 None
 1.04A 3bjwB-4dshA:
undetectable		 3bjwB-4dshA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 11 VAL A 297
GLY A 299
SER A 345
THR A 329
LYS A 311
 None
 1.10A 3bjwE-4dshA:
undetectable		 3bjwE-4dshA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 VAL A 297
GLY A 299
SER A 345
THR A 329
LYS A 311
 None
 1.04A 3bjwF-4dshA:
undetectable		 3bjwF-4dshA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 441
GLY A  13
GLY A  15
GLY A  20
ILE A  12
 None
FDA  A 502 (-3.3A)
FDA  A 502 (-3.2A)
None
FDA  A 502 (-4.6A)
 0.99A 3eluA-4dshA:
2.8		 3eluA-4dshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 441
GLY A  13
GLY A  15
GLY A  20
ILE A  12
 None
FDA  A 502 (-3.3A)
FDA  A 502 (-3.2A)
None
FDA  A 502 (-4.6A)
 1.03A 3embA-4dshA:
3.1		 3embA-4dshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 441
GLY A  13
GLY A  15
GLY A  20
ILE A  12
 None
FDA  A 502 (-3.3A)
FDA  A 502 (-3.2A)
None
FDA  A 502 (-4.6A)
 0.98A 3gczA-4dshA:
3.2		 3gczA-4dshA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 9 PHE A 424
GLY A 425
PRO A 264
GLY A 432
ILE A 391
 None
None
None
FDA  A 502 (-4.6A)
EPE  A 506 ( 4.8A)
 1.42A 3ko0H-4dshA:
undetectable
3ko0I-4dshA:
undetectable		 3ko0H-4dshA:
10.67
3ko0I-4dshA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 TYR A  70
GLY A  20
ALA A  21
LEU A  25
LEU A  28
 None
 1.01A 3n8yB-4dshA:
undetectable		 3n8yB-4dshA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 8 ALA A 469
ASP A  72
ASP A 435
SER A  66
 None
 1.03A 3qj7A-4dshA:
undetectable
3qj7D-4dshA:
undetectable		 3qj7A-4dshA:
19.03
3qj7D-4dshA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 THR A 245
ILE A 239
TYR A  36
PHE A 248
PHE A 234
 None
 1.46A 3rzeA-4dshA:
undetectable		 3rzeA-4dshA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 5 ILE A 214
PRO A 207
SER A  46
GLY A 211
 None
None
FDA  A 502 (-3.1A)
None
 1.12A 3tkdB-4dshA:
undetectable		 3tkdB-4dshA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 5 ILE A 214
PRO A 207
SER A  46
GLY A 211
 None
None
FDA  A 502 (-3.1A)
None
 1.09A 3tkdA-4dshA:
undetectable		 3tkdA-4dshA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		3 / 3 LEU A 269
MET A 271
ASP A 240
 None
FDA  A 502 ( 4.9A)
None
 0.80A 3v5wA-4dshA:
undetectable		 3v5wA-4dshA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 7 ASP A  58
GLY A  44
THR A 212
PHE A  49
 None
FDA  A 502 (-3.2A)
None
None
 1.15A 3vnsA-4dshA:
undetectable		 3vnsA-4dshA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 6 ARG A 176
ASP A 435
ASN A 433
TYR A 429
 UDP  A 501 (-4.1A)
None
FDA  A 502 (-4.3A)
UDP  A 501 (-4.4A)
 1.23A 3wfaA-4dshA:
undetectable
3wfaB-4dshA:
undetectable		 3wfaA-4dshA:
20.69
3wfaB-4dshA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		3 / 3 ASN A 465
GLU A 175
ARG A 176
 None
None
UDP  A 501 (-4.1A)
 0.99A 3wxoA-4dshA:
undetectable		 3wxoA-4dshA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 8 ARG A 416
LEU A 413
TYR A 280
GLU A 412
 None
 1.23A 3zmdA-4dshA:
undetectable
3zmdB-4dshA:
undetectable		 3zmdA-4dshA:
15.02
3zmdB-4dshA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 MET A  75
ILE A  11
LEU A 228
GLY A  15
SER A  46
 None
None
None
FDA  A 502 (-3.2A)
FDA  A 502 (-3.1A)
 1.27A 4djfB-4dshA:
undetectable		 4djfB-4dshA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A  13
GLY A  15
VAL A 263
THR A 262
VAL A  10
 FDA  A 502 (-3.3A)
FDA  A 502 (-3.2A)
FDA  A 502 (-3.9A)
FDA  A 502 ( 4.4A)
None
 1.19A 4f84A-4dshA:
undetectable		 4f84A-4dshA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		3 / 3 GLU A 352
ARG A 390
HIS A 360
 None
None
SO4  A 505 (-3.9A)
 0.62A 4kf9A-4dshA:
undetectable		 4kf9A-4dshA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 7 VAL A 442
ILE A 445
LEU A 228
LEU A  35
 None
 0.91A 4l1wA-4dshA:
undetectable		 4l1wA-4dshA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 10 LEU A  35
GLY A  20
ALA A  21
GLY A 422
ILE A  11
 None
None
None
FDA  A 502 (-3.3A)
None
 0.90A 4ll3A-4dshA:
undetectable		 4ll3A-4dshA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 SER A 437
GLN A 434
ALA A  78
MET A  75
PHE A  71
 FDA  A 502 (-3.1A)
FDA  A 502 (-4.0A)
None
None
None
 1.28A 4r29A-4dshA:
undetectable		 4r29A-4dshA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		6 / 12 LEU A  35
GLY A  20
ALA A  21
ILE A   9
VAL A 448
ILE A  11
 None
 1.32A 5e5kA-4dshA:
undetectable		 5e5kA-4dshA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 8 GLY A 422
ALA A 444
THR A 457
HIS A 436
 FDA  A 502 (-3.3A)
None
None
None
 0.86A 5eezL-4dshA:
undetectable
5eezV-4dshA:
undetectable		 5eezL-4dshA:
9.36
5eezV-4dshA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 8 GLY A 422
ALA A 444
THR A 457
HIS A 436
 FDA  A 502 (-3.3A)
None
None
None
 0.87A 5ef1L-4dshA:
undetectable
5ef1V-4dshA:
undetectable		 5ef1L-4dshA:
9.36
5ef1V-4dshA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 8 GLY A 422
ALA A 444
THR A 457
HIS A 436
 FDA  A 502 (-3.3A)
None
None
None
 0.87A 5ef2L-4dshA:
undetectable
5ef2V-4dshA:
undetectable		 5ef2L-4dshA:
9.36
5ef2V-4dshA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 441
GLY A  13
GLY A  15
GLY A  20
ILE A  12
 None
FDA  A 502 (-3.3A)
FDA  A 502 (-3.2A)
None
FDA  A 502 (-4.6A)
 0.99A 5ehiA-4dshA:
2.6		 5ehiA-4dshA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 441
GLY A  13
GLY A  15
GLY A  20
ILE A  12
 None
FDA  A 502 (-3.3A)
FDA  A 502 (-3.2A)
None
FDA  A 502 (-4.6A)
 1.02A 5ehiC-4dshA:
undetectable		 5ehiC-4dshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 441
GLY A  13
GLY A  15
GLY A  20
ILE A  12
 None
FDA  A 502 (-3.3A)
FDA  A 502 (-3.2A)
None
FDA  A 502 (-4.6A)
 0.99A 5eiwA-4dshA:
undetectable		 5eiwA-4dshA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 GLY A 441
GLY A  13
GLY A  15
GLY A  20
ILE A  12
 None
FDA  A 502 (-3.3A)
FDA  A 502 (-3.2A)
None
FDA  A 502 (-4.6A)
 0.96A 5ekxA-4dshA:
2.8		 5ekxA-4dshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 5 ALA A 373
PRO A 319
GLY A 145
LEU A 109
 None
 0.93A 5eslA-4dshA:
undetectable		 5eslA-4dshA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M10_A_NCAA603_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 5 LEU A 310
PHE A 318
LEU A 346
TRP A  97
 None
 1.42A 5m10A-4dshA:
9.9		 5m10A-4dshA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		4 / 8 ILE A  11
ALA A  22
ALA A 444
ILE A 445
 None
 0.68A 5mvmA-4dshA:
undetectable
5mvmB-4dshA:
undetectable		 5mvmA-4dshA:
9.38
5mvmB-4dshA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 LEU A  35
GLY A  20
ALA A  21
GLY A 422
ILE A  11
 None
None
None
FDA  A 502 (-3.3A)
None
 0.77A 5t8hB-4dshA:
undetectable		 5t8hB-4dshA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 445
PHE A 438
PHE A 473
GLY A  18
LEU A 223
 None
 1.25A 5v5zA-4dshA:
undetectable		 5v5zA-4dshA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 ILE A  12
VAL A 458
VAL A 431
GLU A 455
VAL A 448
 FDA  A 502 (-4.6A)
None
None
None
None
 1.37A 6bzoC-4dshA:
undetectable		 6bzoC-4dshA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4dsh UDP-GALACTOPYRANOSE
MUTASE
(Trypanosoma
cruzi) 		5 / 12 PHE A 248
VAL A 254
HIS A  34
THR A 229
ALA A  21
 None
 1.13A 6djzA-4dshA:
undetectable		 6djzA-4dshA:
18.30