SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		4 / 8 THR A  47
GLY A  50
THR A  70
ALA A  71
 None
 0.77A 2a1hA-4dt5A:
undetectable
2a1hB-4dt5A:
undetectable		 2a1hA-4dt5A:
13.97
2a1hB-4dt5A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 12 ALA A  25
ALA A  44
ALA A  13
GLY A  48
GLY A   8
 None
 1.08A 2igtA-4dt5A:
undetectable		 2igtA-4dt5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 12 ALA A  25
ALA A  44
ALA A  13
GLY A  48
GLY A   8
 None
 1.07A 2igtB-4dt5A:
undetectable		 2igtB-4dt5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 12 GLY A  27
GLY A  69
ALA A  51
ALA A  53
ALA A  73
 None
 0.96A 3sudA-4dt5A:
undetectable		 3sudA-4dt5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 12 GLY A  27
GLY A  69
ALA A  51
ALA A  53
ALA A  73
 None
 0.95A 3sudC-4dt5A:
undetectable		 3sudC-4dt5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 12 GLY A  27
GLY A  69
ALA A  51
ALA A  53
ALA A  73
 None
 0.94A 3sudD-4dt5A:
undetectable		 3sudD-4dt5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 11 ALA A  44
SER A  36
SER A  42
GLY A  34
THR A  15
 None
 1.31A 4mmaA-4dt5A:
undetectable		 4mmaA-4dt5A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 11 SER A  75
THR A  41
GLY A  81
ALA A  83
THR A 101
 None
 1.50A 4qvlV-4dt5A:
undetectable
4qvlb-4dt5A:
undetectable		 4qvlV-4dt5A:
18.49
4qvlb-4dt5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 11 SER A  75
THR A  41
GLY A  81
ALA A  83
THR A 101
 None
 1.50A 4qvlH-4dt5A:
undetectable
4qvlN-4dt5A:
undetectable		 4qvlH-4dt5A:
18.49
4qvlN-4dt5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 11 THR A  52
ALA A  28
GLY A  27
THR A  26
ALA A  25
 None
 1.12A 4qvvH-4dt5A:
undetectable		 4qvvH-4dt5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 11 THR A  52
ALA A  28
GLY A  27
THR A  26
ALA A  25
 None
 1.12A 4qvvV-4dt5A:
undetectable		 4qvvV-4dt5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 11 THR A  52
ALA A  28
GLY A  27
THR A  26
ALA A  25
 None
 1.12A 4qvyH-4dt5A:
undetectable		 4qvyH-4dt5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 11 SER A  75
THR A  41
GLY A  81
ALA A  83
THR A 101
 None
 1.49A 5bxnV-4dt5A:
undetectable
5bxnb-4dt5A:
undetectable		 5bxnV-4dt5A:
19.83
5bxnb-4dt5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 11 SER A  75
THR A  41
GLY A  81
ALA A  83
THR A 101
 None
 1.48A 5bxnH-4dt5A:
undetectable
5bxnN-4dt5A:
undetectable		 5bxnH-4dt5A:
19.83
5bxnN-4dt5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 11 THR A  52
ALA A  28
GLY A  27
THR A  26
ALA A  25
 None
 1.13A 5d0xV-4dt5A:
undetectable		 5d0xV-4dt5A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 12 THR A 132
THR A  86
THR A  88
SER A  98
ALA A  73
 None
 1.40A 5lf3b-4dt5A:
undetectable		 5lf3b-4dt5A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 4dt5 ANTIFREEZE PROTEIN
(Rhagium
inquisitor) 		5 / 12 THR A 132
THR A  86
THR A  88
SER A  98
ALA A  73
 None
 1.40A 5lf3N-4dt5A:
undetectable		 5lf3N-4dt5A:
22.69