SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dte'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_A_SALA3005_1
(XANTHINE
DEHYDROGENASE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		5 / 9 LEU A 158
ARG A 315
PHE A 143
VAL A 148
LEU A 149
 None
 1.49A 1fo4A-4dteA:
undetectable		 1fo4A-4dteA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		4 / 6 LEU A 239
ASN A 243
LEU A 246
PHE A  15
 None
 1.01A 1ru9H-4dteA:
undetectable
1ru9L-4dteA:
undetectable		 1ru9H-4dteA:
19.72
1ru9L-4dteA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		4 / 6 LEU A 239
ASN A 243
LEU A 246
PHE A  15
 None
 1.00A 1rukH-4dteA:
undetectable
1rukL-4dteA:
undetectable		 1rukH-4dteA:
19.72
1rukL-4dteA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		4 / 6 ARG A 154
GLU A 151
PRO A 121
ALA A 124
 None
 1.29A 2ejfB-4dteA:
undetectable		 2ejfB-4dteA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		5 / 10 LEU A 362
SER A 248
LEU A  12
ASP A   9
ASP A   5
 None
 1.34A 2j1gE-4dteA:
undetectable
2j1gF-4dteA:
undetectable		 2j1gE-4dteA:
19.13
2j1gF-4dteA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		3 / 3 SER A  36
HIS A 356
ASP A  81
 None
 0.66A 2oxtA-4dteA:
undetectable		 2oxtA-4dteA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		3 / 3 LEU A 228
ASN A 201
ARG A 255
 None
 0.87A 2qhfA-4dteA:
undetectable		 2qhfA-4dteA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		4 / 8 GLN A 120
GLN A 115
ASP A  92
SER A 119
 None
 1.25A 2xz5C-4dteA:
undetectable
2xz5D-4dteA:
undetectable		 2xz5C-4dteA:
20.75
2xz5D-4dteA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		4 / 5 ILE A  34
SER A  30
PRO A  31
PHE A 364
 None
 1.39A 3bjwC-4dteA:
undetectable		 3bjwC-4dteA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		4 / 8 TYR A 374
GLY A 138
SER A 141
ILE A 140
 None
 0.89A 3ihzB-4dteA:
undetectable		 3ihzB-4dteA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		5 / 9 LEU A 161
ILE A  34
ALA A  35
THR A   8
ALA A 361
 None
 1.19A 3mdtA-4dteA:
undetectable		 3mdtA-4dteA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		5 / 11 VAL A 320
LEU A 318
TYR A 220
ILE A 354
LEU A 229
 None
 1.14A 3n8yA-4dteA:
undetectable		 3n8yA-4dteA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		5 / 12 TYR A  32
GLY A  11
SER A  30
ASP A   9
GLN A   7
 None
 1.13A 3nmuA-4dteA:
undetectable
3nmuF-4dteA:
undetectable		 3nmuA-4dteA:
22.17
3nmuF-4dteA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		6 / 12 GLY A  39
ARG A 295
GLY A  44
ALA A  45
ALA A 296
ASP A 289
 None
 1.34A 3sugA-4dteA:
undetectable		 3sugA-4dteA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		5 / 9 LEU A 287
ALA A  41
VAL A 309
LEU A 155
ILE A 290
 None
 1.37A 3wsjA-4dteA:
undetectable		 3wsjA-4dteA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		4 / 6 GLY A 203
TRP A 254
GLU A 245
ARG A 250
 None
 1.00A 4bqfA-4dteA:
undetectable		 4bqfA-4dteA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		4 / 7 TYR A  32
VAL A  83
ILE A 225
ILE A 354
 None
 0.60A 4lv9B-4dteA:
undetectable		 4lv9B-4dteA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		3 / 3 ALA A 160
ASN A 159
LEU A 158
 None
 0.49A 5i1oA-4dteA:
undetectable		 5i1oA-4dteA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		4 / 4 GLN A 355
THR A 359
GLU A  80
LEU A 161
 None
 1.08A 5m66A-4dteA:
undetectable		 5m66A-4dteA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1
(Danio
rerio) 		5 / 12 GLY A 366
VAL A 312
VAL A  37
GLY A  33
ILE A  34
 None
 1.07A 5vopA-4dteA:
undetectable		 5vopA-4dteA:
22.55