SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dtg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TUF_B_AZ1B503_1 (DIAMINOPIMELATE DECARBOXYLASE)	4dtg	HUMANIZED RECOMBINANT FAB FRAGMENT, FAB 2021, OF A MURINE ANTIBODY, HEAVY CHAIN TISSUE FACTOR PATHWAY INHIBITOR (Homo sapiens)	4 / 6	GLU K 11 SER H 54 TYR H 59 TYR H 57	PGE H 304 ( 3.5A) None None None	1.21A	1tufA-4dtgK: undetectable 1tufB-4dtgK: undetectable	1tufA-4dtgK: 9.76 1tufB-4dtgK: 9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EAH_F_ACTF402_0 (ACTIN, ALPHA SKELETAL MUSCLE)	4dtg	HUMANIZED RECOMBINANT FAB FRAGMENT, FAB 2021, OF A MURINE ANTIBODY, HEAVY CHAIN TISSUE FACTOR PATHWAY INHIBITOR (Homo sapiens; Homo sapiens)	3 / 3	PHE H 60 ASP H 62 ARG K 17	None	0.77A	4eahF-4dtgH: undetectable	4eahF-4dtgH: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EAH_G_ACTG401_0 (ACTIN, ALPHA SKELETAL MUSCLE)	4dtg	HUMANIZED RECOMBINANT FAB FRAGMENT, FAB 2021, OF A MURINE ANTIBODY, HEAVY CHAIN TISSUE FACTOR PATHWAY INHIBITOR (Homo sapiens; Homo sapiens)	3 / 3	PHE H 60 ASP H 62 ARG K 17	None	0.77A	4eahG-4dtgH: undetectable	4eahG-4dtgH: 21.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1TUF_B_AZ1B503_1","DIAMINOPIMELATE DECARBOXYLASE;DIAMINOPIMELATE DECARBOXYLASE","4dtg","HUMANIZED RECOMBINANT FAB FRAGMENT, FAB 2021, OF A MURINE ANTIBODY, HEAVY CHAIN;TISSUE FACTOR PATHWAY INHIBITOR","Homo sapiens",4,"GLU K  11;SER H  54;TYR H  59;TYR H  57","PGE H 304 ( 3.5A);None;None;None","1.21A","1tufA-4dtgK:undetectable;1tufB-4dtgK:undetectable","1tufA-4dtgK:9.76;1tufB-4dtgK:9.76"],["4EAH_F_ACTF402_0","ACTIN, ALPHA SKELETAL MUSCLE","4dtg","HUMANIZED RECOMBINANT FAB FRAGMENT, FAB 2021, OF A MURINE ANTIBODY, HEAVY CHAIN;TISSUE FACTOR PATHWAY INHIBITOR","Homo sapiens;Homo sapiens",3,"PHE H  60;ASP H  62;ARG K  17","None","0.77A","4eahF-4dtgH:undetectable","4eahF-4dtgH:21.00"],["4EAH_G_ACTG401_0","ACTIN, ALPHA SKELETAL MUSCLE","4dtg","HUMANIZED RECOMBINANT FAB FRAGMENT, FAB 2021, OF A MURINE ANTIBODY, HEAVY CHAIN;TISSUE FACTOR PATHWAY INHIBITOR","Homo sapiens;Homo sapiens",3,"PHE H  60;ASP H  62;ARG K  17","None","0.77A","4eahG-4dtgH:undetectable","4eahG-4dtgH:21.00"]]