SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dth'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		5 / 10 LEU A 182
VAL A 167
ILE A 336
TYR A 218
ILE A 222
 None
 1.41A 1q6iB-4dthA:
undetectable		 1q6iB-4dthA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		4 / 5 ALA A 230
TYR A 236
ILE A 237
ASP A 241
 None
 1.12A 1upfC-4dthA:
undetectable		 1upfC-4dthA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		4 / 7 VAL A 165
SER A  11
LEU A 182
THR A 177
 None
 1.08A 2f78B-4dthA:
undetectable		 2f78B-4dthA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		4 / 6 ALA A  20
LEU A  19
ALA A 103
THR A 104
 None
 0.88A 3b6hA-4dthA:
undetectable		 3b6hA-4dthA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		4 / 6 ALA A  20
LEU A  19
ALA A 103
THR A 104
 None
 0.93A 3b6hB-4dthA:
undetectable		 3b6hB-4dthA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		5 / 11 LEU A 347
SER A 349
ILE A  13
CYH A  84
ASP A  87
 None
 1.35A 3ko0A-4dthA:
undetectable
3ko0B-4dthA:
undetectable
3ko0C-4dthA:
undetectable
3ko0D-4dthA:
undetectable		 3ko0A-4dthA:
13.44
3ko0B-4dthA:
13.44
3ko0C-4dthA:
13.44
3ko0D-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		5 / 11 ASP A  87
LEU A 347
SER A 349
ILE A  13
CYH A  84
 None
 1.31A 3ko0C-4dthA:
undetectable
3ko0D-4dthA:
undetectable
3ko0E-4dthA:
undetectable
3ko0F-4dthA:
undetectable		 3ko0C-4dthA:
13.44
3ko0D-4dthA:
13.44
3ko0E-4dthA:
13.44
3ko0F-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE202_1
(PROTEIN S100-A4)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		5 / 11 LEU A 347
SER A 349
ILE A  13
CYH A  84
ASP A  87
 None
 1.36A 3ko0C-4dthA:
undetectable
3ko0D-4dthA:
undetectable
3ko0E-4dthA:
undetectable
3ko0F-4dthA:
undetectable		 3ko0C-4dthA:
13.44
3ko0D-4dthA:
13.44
3ko0E-4dthA:
13.44
3ko0F-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		5 / 11 ASP A  87
LEU A 347
SER A 349
ILE A  13
CYH A  84
 None
 1.39A 3ko0E-4dthA:
undetectable
3ko0F-4dthA:
undetectable
3ko0G-4dthA:
undetectable
3ko0H-4dthA:
undetectable		 3ko0E-4dthA:
13.44
3ko0F-4dthA:
13.44
3ko0G-4dthA:
13.44
3ko0H-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		5 / 12 ASP A  87
LEU A 347
SER A 349
ILE A  13
CYH A  84
 None
 1.40A 3ko0G-4dthA:
undetectable
3ko0H-4dthA:
undetectable
3ko0I-4dthA:
undetectable
3ko0J-4dthA:
undetectable		 3ko0G-4dthA:
13.44
3ko0H-4dthA:
13.44
3ko0I-4dthA:
13.44
3ko0J-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		5 / 11 ASP A  87
LEU A 347
SER A 349
ILE A  13
CYH A  84
 None
 1.37A 3ko0K-4dthA:
undetectable
3ko0L-4dthA:
undetectable
3ko0M-4dthA:
undetectable
3ko0N-4dthA:
undetectable		 3ko0K-4dthA:
13.44
3ko0L-4dthA:
13.44
3ko0M-4dthA:
13.44
3ko0N-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		5 / 11 LEU A 347
SER A 349
ILE A  13
CYH A  84
ASP A  87
 None
 1.36A 3ko0O-4dthA:
undetectable
3ko0P-4dthA:
undetectable
3ko0Q-4dthA:
undetectable
3ko0R-4dthA:
undetectable		 3ko0O-4dthA:
13.44
3ko0P-4dthA:
13.44
3ko0Q-4dthA:
13.44
3ko0R-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		5 / 10 LEU A 347
SER A 349
ILE A  13
CYH A  84
ASP A  87
 None
 1.35A 3ko0O-4dthA:
undetectable
3ko0P-4dthA:
undetectable
3ko0Q-4dthA:
undetectable
3ko0R-4dthA:
undetectable		 3ko0O-4dthA:
13.44
3ko0P-4dthA:
13.44
3ko0Q-4dthA:
13.44
3ko0R-4dthA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		3 / 3 LYS A 270
PRO A 271
SER A 272
 None
 0.40A 4k50I-4dthA:
undetectable		 4k50I-4dthA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 4dth VGRG PROTEIN
(Vibrio
cholerae) 		3 / 3 TRP A 263
ILE A 222
GLU A 315
 None
 0.83A 6hcxA-4dthA:
undetectable		 6hcxA-4dthA:
10.96