SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4du5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		3 / 3 MET A 140
GLU A  61
ASN A  63
 None
 1.01A 3a27A-4du5A:
3.6		 3a27A-4du5A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		3 / 3 PRO A 127
PHE A  53
LYS A 119
 None
 1.22A 3bjwG-4du5A:
undetectable		 3bjwG-4du5A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		5 / 10 VAL A 291
LEU A 331
SER A 293
GLY A 308
TRP A 310
 None
 1.31A 3ls4H-4du5A:
undetectable		 3ls4H-4du5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		5 / 12 GLY A  59
ALA A  60
ASN A  63
GLY A 282
ASP A 285
 CL  A 401 ( 3.8A)
CL  A 401 ( 4.3A)
None
None
None
 0.63A 3uq6B-4du5A:
30.1		 3uq6B-4du5A:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		5 / 12 GLY A  59
ALA A  60
ASN A  63
GLY A 282
ASP A 285
 CL  A 401 ( 3.8A)
CL  A 401 ( 4.3A)
None
None
None
 0.62A 3vaqB-4du5A:
30.4		 3vaqB-4du5A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		5 / 12 LEU A 197
ALA A  60
ASN A  63
GLY A 282
ASP A 285
 None
CL  A 401 ( 4.3A)
None
None
None
 0.96A 4dc3A-4du5A:
30.5		 4dc3A-4du5A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		5 / 12 LEU A 197
GLY A  59
ASN A  63
GLY A 282
ASP A 285
 None
CL  A 401 ( 3.8A)
None
None
None
 0.92A 4dc3B-4du5A:
30.6		 4dc3B-4du5A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		5 / 12 LEU A 197
GLY A  59
ASN A  63
GLY A 282
ASP A 285
 None
CL  A 401 ( 3.8A)
None
None
None
 0.90A 4n09B-4du5A:
29.7		 4n09B-4du5A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		5 / 12 LEU A 197
GLY A  59
ASN A  63
GLY A 282
ASP A 285
 None
CL  A 401 ( 3.8A)
None
None
None
 0.91A 4n09C-4du5A:
29.5		 4n09C-4du5A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		5 / 10 LEU A 228
LEU A 170
ALA A 173
ALA A 207
GLY A 160
 None
 1.32A 4rn6A-4du5A:
undetectable		 4rn6A-4du5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		4 / 7 ILE A 208
PHE A 189
THR A 169
LEU A 170
 None
 0.91A 5b3sN-4du5A:
undetectable
5b3sW-4du5A:
undetectable		 5b3sN-4du5A:
21.04
5b3sW-4du5A:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		4 / 7 ILE A 208
PHE A 189
THR A 169
LEU A 170
 None
 0.93A 5iy5N-4du5A:
undetectable
5iy5W-4du5A:
undetectable		 5iy5N-4du5A:
21.04
5iy5W-4du5A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		4 / 5 GLY A  82
ARG A  80
ASP A  84
MET A  86
 None
 1.29A 5ubbA-4du5A:
4.0		 5ubbA-4du5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4du5 PFKB
(Polaromonas
sp.
JS666) 		4 / 8 ASP A 178
HIS A 155
ARG A 181
ASP A 216
 None
 1.06A 6mn4A-4du5A:
undetectable		 6mn4A-4du5A:
25.15