SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4du6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4du6 GTP CYCLOHYDROLASE 1
(Yersinia
pestis) 		5 / 11 ALA A 120
VAL A 140
VAL A 170
LEU A  15
ALA A 160
 None
 1.25A 1n4hA-4du6A:
undetectable		 1n4hA-4du6A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4du6 GTP CYCLOHYDROLASE 1
(Yersinia
pestis) 		3 / 3 ARG A 214
GLU A 211
GLN A 210
 None
 1.08A 2p16A-4du6A:
undetectable		 2p16A-4du6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4du6 GTP CYCLOHYDROLASE 1
(Yersinia
pestis) 		5 / 12 PHE A 143
ILE A 157
VAL A 140
ILE A 136
ALA A 160
 None
 0.87A 3fpjA-4du6A:
undetectable		 3fpjA-4du6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4du6 GTP CYCLOHYDROLASE 1
(Yersinia
pestis) 		5 / 12 PHE A 143
VAL A 140
ILE A 136
ALA A 160
VAL A 170
 None
 1.01A 3fpjA-4du6A:
undetectable		 3fpjA-4du6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4du6 GTP CYCLOHYDROLASE 1
(Yersinia
pestis) 		5 / 10 ALA A 123
LEU A 198
LEU A 213
VAL A 216
THR A  99
 None
 1.13A 3jw5B-4du6A:
undetectable		 3jw5B-4du6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4du6 GTP CYCLOHYDROLASE 1
(Yersinia
pestis) 		5 / 10 GLU A  21
LEU A  15
ILE A 139
LEU A 164
PHE A  82
 None
 1.18A 3jw5B-4du6A:
undetectable		 3jw5B-4du6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4du6 GTP CYCLOHYDROLASE 1
(Yersinia
pestis) 		5 / 11 LEU A 161
VAL A 140
ALA A 120
ALA A 123
THR A  99
 None
 1.10A 3mdtB-4du6A:
undetectable		 3mdtB-4du6A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 4du6 GTP CYCLOHYDROLASE 1
(Yersinia
pestis) 		5 / 12 LEU A 161
ILE A  85
ILE A 157
ALA A 144
PHE A  82
 None
 1.37A 3vw1B-4du6A:
undetectable		 3vw1B-4du6A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 4du6 GTP CYCLOHYDROLASE 1
(Yersinia
pestis) 		4 / 5 THR A 108
THR A 104
GLN A 141
ASP A 102
 None
 1.43A 6ecxA-4du6A:
undetectable		 6ecxA-4du6A:
20.87