SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4dun PUTATIVE PHENAZINE
BIOSYNTHESIS
PHZC/PHZF PROTEIN
(Clostridioides
difficile) 		4 / 6 THR A 200
SER A 186
GLY A 172
ILE A 173
 BTB  A 302 ( 3.8A)
None
None
None
 0.86A 1gtnD-4dunA:
undetectable
1gtnE-4dunA:
undetectable		 1gtnD-4dunA:
14.71
1gtnE-4dunA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4dun PUTATIVE PHENAZINE
BIOSYNTHESIS
PHZC/PHZF PROTEIN
(Clostridioides
difficile) 		5 / 12 THR A  95
PHE A  93
PHE A 113
ALA A  19
ALA A  75
 None
 1.29A 1q23A-4dunA:
undetectable
1q23B-4dunA:
undetectable		 1q23A-4dunA:
22.38
1q23B-4dunA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 4dun PUTATIVE PHENAZINE
BIOSYNTHESIS
PHZC/PHZF PROTEIN
(Clostridioides
difficile) 		3 / 3 LEU A 207
TRP A 170
TYR A 188
 None
None
BTB  A 302 (-4.4A)
 1.01A 3aicF-4dunA:
undetectable		 3aicF-4dunA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_2
(DIPEPTIDYL PEPTIDASE
4)		 4dun PUTATIVE PHENAZINE
BIOSYNTHESIS
PHZC/PHZF PROTEIN
(Clostridioides
difficile) 		3 / 3 ARG A  58
TYR A   4
ASN A  40
 None
 0.94A 4ffwB-4dunA:
undetectable		 4ffwB-4dunA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4dun PUTATIVE PHENAZINE
BIOSYNTHESIS
PHZC/PHZF PROTEIN
(Clostridioides
difficile) 		5 / 12 LEU A 167
ILE A 173
LEU A 144
GLY A 132
VAL A 138
 None
 0.94A 4nkvB-4dunA:
undetectable		 4nkvB-4dunA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 4dun PUTATIVE PHENAZINE
BIOSYNTHESIS
PHZC/PHZF PROTEIN
(Clostridioides
difficile) 		5 / 12 ASN A  17
ASP A 197
ARG A 142
ASN A 206
LEU A 207
 BTB  A 302 ( 4.6A)
BTB  A 302 (-2.8A)
BTB  A 302 ( 4.4A)
None
None
 1.25A 5l7iA-4dunA:
undetectable		 5l7iA-4dunA:
18.34