SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.85A 1jnoA-4dvgA:
undetectable		 1jnoA-4dvgA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.85A 1jnoB-4dvgA:
undetectable		 1jnoB-4dvgA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.90A 1jo3A-4dvgA:
undetectable		 1jo3A-4dvgA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.90A 1jo3B-4dvgA:
undetectable		 1jo3B-4dvgA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		4 / 7 GLU B 246
LEU B 226
MET B 177
LEU B 173
 None
 1.15A 1linA-4dvgB:
undetectable		 1linA-4dvgB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.90A 1magA-4dvgA:
undetectable		 1magA-4dvgA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.90A 1magB-4dvgA:
undetectable		 1magB-4dvgA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.87A 1ng8A-4dvgA:
undetectable		 1ng8A-4dvgA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.86A 1ng8B-4dvgA:
undetectable		 1ng8B-4dvgA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.92A 1nruA-4dvgA:
undetectable		 1nruA-4dvgA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ALA A  76
VAL A  26
TRP A 114
 None
 0.92A 1nruB-4dvgA:
undetectable		 1nruB-4dvgA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		4 / 7 ASP A  28
ASN A 109
TRP A 114
ARG A  85
 None
 1.45A 1rqpB-4dvgA:
undetectable		 1rqpB-4dvgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		3 / 3 PRO B 317
ASP B 315
ASP B 267
 None
 0.74A 1sqfA-4dvgB:
undetectable		 1sqfA-4dvgB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_2
(DEOXYCYTIDINE KINASE)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		4 / 4 ILE B 184
ASP B 144
LEU B 176
ARG B 234
 None
 1.21A 2a7qA-4dvgB:
undetectable		 2a7qA-4dvgB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 4dvg DIAPHANOUS PROTEIN
RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		3 / 3 ASP A 108
THR B 236
PRO B 237
 None
 0.72A 2pynB-4dvgA:
undetectable		 2pynB-4dvgA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		4 / 7 ASP A  28
ASN A 109
TRP A 114
ARG A  85
 None
 1.46A 2v7uB-4dvgA:
undetectable		 2v7uB-4dvgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4dvg RHO-LIKE SMALL
GTPASE
DIAPHANOUS PROTEIN
(Entamoeba
histolytica;
Entamoeba
histolytica) 		4 / 6 ARG A  83
SER B 162
PHE B 163
ASP B 113
 None
 1.44A 3jqaA-4dvgA:
5.8		 3jqaA-4dvgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 4dvg RHO-LIKE SMALL
GTPASE
DIAPHANOUS PROTEIN
(Entamoeba
histolytica;
Entamoeba
histolytica) 		4 / 6 ARG A  83
SER B 162
PHE B 163
ASP B 113
 None
 1.40A 3jqaC-4dvgA:
5.8		 3jqaC-4dvgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 4dvg RHO-LIKE SMALL
GTPASE
DIAPHANOUS PROTEIN
(Entamoeba
histolytica;
Entamoeba
histolytica) 		4 / 6 ARG A  83
SER B 162
PHE B 163
ASP B 113
 None
 1.41A 3jqaD-4dvgA:
5.9		 3jqaD-4dvgA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4dvg RHO-LIKE SMALL
GTPASE
DIAPHANOUS PROTEIN
(Entamoeba
histolytica;
Entamoeba
histolytica) 		3 / 3 ASN A 103
ASP A  28
ARG B 197
 None
 0.95A 3k13C-4dvgA:
2.9		 3k13C-4dvgA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 4dvg RHO-LIKE SMALL
GTPASE
DIAPHANOUS PROTEIN
(Entamoeba
histolytica;
Entamoeba
histolytica) 		3 / 3 ASP B 238
GLU A  79
SER B 297
 None
 0.61A 3p2kA-4dvgB:
undetectable		 3p2kA-4dvgB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		4 / 6 SER A 111
GLU A 148
ASP A 143
ASP A 108
 None
 1.38A 4blvA-4dvgA:
undetectable		 4blvA-4dvgA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		4 / 6 VAL A 128
VAL A  94
ILE A  23
LEU A  36
 None
 0.89A 4l1wB-4dvgA:
undetectable		 4l1wB-4dvgA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		5 / 12 ALA A  39
ALA A 164
SER A 166
LEU A  96
ILE A 162
 None
None
GSP  A 200 (-3.6A)
None
None
 1.16A 4lnxA-4dvgA:
undetectable		 4lnxA-4dvgA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		6 / 11 LEU A 172
VAL A  25
LEU A  96
CYH A  98
LEU A 132
ALA A 164
 None
 1.50A 4p65B-4dvgA:
undetectable
4p65D-4dvgA:
undetectable
4p65G-4dvgA:
undetectable
4p65H-4dvgA:
undetectable		 4p65B-4dvgA:
10.71
4p65D-4dvgA:
10.71
4p65G-4dvgA:
8.86
4p65H-4dvgA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		3 / 3 ALA B 273
ASN B 276
LEU B 277
 None
 0.33A 5i1nB-4dvgB:
undetectable		 5i1nB-4dvgB:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		3 / 3 ALA B 273
ASN B 276
LEU B 277
 None
 0.33A 5i1oC-4dvgB:
undetectable		 5i1oC-4dvgB:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		3 / 3 ALA B 273
ASN B 276
LEU B 277
 None
 0.32A 5i1pA-4dvgB:
undetectable		 5i1pA-4dvgB:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		5 / 12 ALA B 305
LEU B 245
PHE B 302
SER B 299
LEU B 226
 None
 1.35A 5uanB-4dvgB:
undetectable		 5uanB-4dvgB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		5 / 12 LEU B 176
LEU B 173
GLY B 172
GLY B 171
VAL B 170
 None
 0.95A 5uc1A-4dvgB:
undetectable		 5uc1A-4dvgB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		5 / 12 LEU B 176
LEU B 173
GLY B 172
GLY B 171
VAL B 170
 None
 0.97A 5uc1B-4dvgB:
undetectable		 5uc1B-4dvgB:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		4 / 8 ILE B 243
PHE B 290
ALA B 273
LEU B 277
 None
 0.88A 5y7pC-4dvgB:
undetectable		 5y7pC-4dvgB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 4dvg RHO-LIKE SMALL
GTPASE
DIAPHANOUS PROTEIN
(Entamoeba
histolytica;
Entamoeba
histolytica) 		3 / 3 ARG B 197
LYS B 198
ARG A  83
 None
 1.02A 6c06D-4dvgB:
0.7		 6c06D-4dvgB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4dvg DIAPHANOUS PROTEIN
(Entamoeba
histolytica) 		5 / 10 GLY B 222
LEU B 226
VAL B 206
ALA B 212
LEU B 203
 None
 1.12A 6czmA-4dvgB:
undetectable
6czmC-4dvgB:
undetectable		 6czmA-4dvgB:
21.15
6czmC-4dvgB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4dvg RHO-LIKE SMALL
GTPASE
(Entamoeba
histolytica) 		4 / 7 ARG A  85
TYR A  89
GLU A 117
GLU A  79
 None
 1.25A 6mn5B-4dvgA:
undetectable		 6mn5B-4dvgA:
15.96