SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 11 HIS A 167
HIS A  28
PHE A  20
PHE A  83
TYR A 180
 FE  A 301 (-3.3A)
FE  A 301 (-3.3A)
None
None
None
 1.39A 1c3sA-4dvhA:
undetectable		 1c3sA-4dvhA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 TRP A 165
GLY A 149
ASN A  71
PRO A 151
 None
 1.15A 1dedA-4dvhA:
undetectable		 1dedA-4dvhA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 167
HIS A  28
PHE A  20
PHE A  83
TYR A 180
 FE  A 301 (-3.3A)
FE  A 301 (-3.3A)
None
None
None
 1.35A 1t69A-4dvhA:
undetectable		 1t69A-4dvhA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 11 PHE A  20
PHE A 115
VAL A 116
TRP A 185
TYR A 180
 None
 1.45A 2vcdA-4dvhA:
undetectable		 2vcdA-4dvhA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 ILE A  57
ASN A  78
PRO A 158
LEU A 152
 None
 1.28A 3oi8A-4dvhA:
undetectable		 3oi8A-4dvhA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 TYR A 180
HIS A  28
HIS A  79
TYR A  82
 None
FE  A 301 (-3.3A)
FE  A 301 (-3.2A)
None
 1.43A 4df2A-4dvhA:
undetectable		 4df2A-4dvhA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 11 HIS A 167
HIS A  28
PHE A  20
PHE A  83
TYR A 180
 FE  A 301 (-3.3A)
FE  A 301 (-3.3A)
None
None
None
 1.37A 4qa0B-4dvhA:
undetectable		 4qa0B-4dvhA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 167
HIS A  28
PHE A  20
PHE A  83
TYR A 180
 FE  A 301 (-3.3A)
FE  A 301 (-3.3A)
None
None
None
 1.47A 5eenB-4dvhA:
undetectable		 5eenB-4dvhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		5 / 12 HIS A 167
HIS A  28
PHE A  20
PHE A  83
TYR A 180
 FE  A 301 (-3.3A)
FE  A 301 (-3.3A)
None
None
None
 1.50A 5ef8B-4dvhA:
undetectable		 5ef8B-4dvhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 8 TRP A 127
ALA A 161
HIS A  28
HIS A  79
 None
None
FE  A 301 (-3.3A)
FE  A 301 (-3.2A)
 1.18A 5km8A-4dvhA:
undetectable
5km8B-4dvhA:
undetectable		 5km8A-4dvhA:
20.38
5km8B-4dvhA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4dvh SUPEROXIDE DISMUTASE
(Trypanosoma
cruzi) 		4 / 4 ILE A  57
LEU A  40
HIS A   0
ALA A   3
 None
 0.65A 6ck2C-4dvhA:
undetectable
6ck2D-4dvhA:
undetectable		 6ck2C-4dvhA:
13.40
6ck2D-4dvhA:
10.06