SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dvy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 ALA P 168
LYS P  36
ILE P 176
LEU P 386
ARG P  60
 None
 1.28A 1d1gA-4dvyP:
undetectable		 1d1gA-4dvyP:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 ILE P 463
TYR P 473
LEU P 471
SER P 472
ILE P 449
 None
 1.12A 1fmlB-4dvyP:
undetectable		 1fmlB-4dvyP:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 TYR P 379
ASP P 447
ILE P 366
LEU P 364
VAL P 356
 None
 1.17A 1r30A-4dvyP:
undetectable		 1r30A-4dvyP:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 7 LEU P  30
GLN P  31
PHE P  34
PHE P 219
 None
 1.01A 2eijP-4dvyP:
4.0
2eijW-4dvyP:
undetectable		 2eijP-4dvyP:
13.39
2eijW-4dvyP:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 ALA P 168
LYS P  36
PHE P  34
LEU P 386
ARG P  60
 None
 1.02A 2oipB-4dvyP:
undetectable		 2oipB-4dvyP:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 ALA P 726
LEU P 699
LYS P 700
PHE P 702
SER P 703
 None
 1.29A 2oipB-4dvyP:
undetectable		 2oipB-4dvyP:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 ALA P 168
LYS P  36
PHE P  34
LEU P 386
ARG P  60
 None
 1.06A 2oipE-4dvyP:
undetectable		 2oipE-4dvyP:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 ILE P 177
ILE P  66
ILE P 181
MET P 188
PHE P  91
 None
 0.93A 2ygoA-4dvyP:
undetectable		 2ygoA-4dvyP:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 7 LEU P  30
GLN P  31
PHE P  34
PHE P 219
 None
 1.00A 2zxwC-4dvyP:
4.0
2zxwJ-4dvyP:
undetectable		 2zxwC-4dvyP:
13.39
2zxwJ-4dvyP:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 6 LEU P  30
GLN P  31
PHE P  34
PHE P 219
 None
 0.96A 2zxwP-4dvyP:
undetectable
2zxwW-4dvyP:
undetectable		 2zxwP-4dvyP:
13.39
2zxwW-4dvyP:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 6 LEU P  30
GLN P  31
PHE P  34
PHE P 219
 None
 0.99A 3ag1C-4dvyP:
undetectable
3ag1J-4dvyP:
undetectable		 3ag1C-4dvyP:
13.39
3ag1J-4dvyP:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 7 LYS P  76
LEU P  69
GLU P  72
SER P  95
 None
 1.42A 3dzgA-4dvyP:
undetectable		 3dzgA-4dvyP:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		3 / 3 ASN P 793
ASP P 787
GLN P 783
 None
 0.83A 3eeyE-4dvyP:
undetectable		 3eeyE-4dvyP:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 ALA P 168
LYS P  36
PHE P  34
LEU P 386
ARG P  60
 None
 1.16A 3hj3B-4dvyP:
undetectable		 3hj3B-4dvyP:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 8 ILE P 138
ALA P  33
PHE P 172
ALA P 168
 None
 0.91A 3hrdA-4dvyP:
undetectable
3hrdB-4dvyP:
undetectable		 3hrdA-4dvyP:
18.74
3hrdB-4dvyP:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 6 ILE P 664
PHE P 543
ALA P 668
ASN P 586
 None
 0.83A 3pgyA-4dvyP:
undetectable
3pgyB-4dvyP:
undetectable		 3pgyA-4dvyP:
19.47
3pgyB-4dvyP:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 7 ASN P 595
PHE P 596
ALA P 593
LEU P 623
 None
 1.06A 3t3sC-4dvyP:
0.0		 3t3sC-4dvyP:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 8 ILE P  66
PHE P  34
GLY P 174
ILE P 215
 None
 0.95A 4qogA-4dvyP:
undetectable
4qogB-4dvyP:
undetectable		 4qogA-4dvyP:
13.19
4qogB-4dvyP:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 9 ALA P  62
ILE P 215
GLY P 174
ALA P 173
VAL P 107
 None
 1.17A 4r1zA-4dvyP:
undetectable		 4r1zA-4dvyP:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 11 LEU P 418
LEU P 415
GLU P 406
ALA P 409
LEU P 408
 None
 1.06A 4wg0B-4dvyP:
undetectable
4wg0C-4dvyP:
undetectable
4wg0D-4dvyP:
undetectable		 4wg0B-4dvyP:
2.23
4wg0C-4dvyP:
2.23
4wg0D-4dvyP:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 11 LEU P 418
LEU P 415
GLU P 406
ALA P 409
LEU P 408
 None
 1.04A 4wg0D-4dvyP:
undetectable
4wg0E-4dvyP:
undetectable
4wg0F-4dvyP:
undetectable		 4wg0D-4dvyP:
2.23
4wg0E-4dvyP:
2.23
4wg0F-4dvyP:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 11 LEU P 418
LEU P 415
GLU P 406
ALA P 409
LEU P 408
 None
 1.06A 4wg0F-4dvyP:
undetectable
4wg0G-4dvyP:
undetectable
4wg0H-4dvyP:
undetectable		 4wg0F-4dvyP:
2.23
4wg0G-4dvyP:
2.23
4wg0H-4dvyP:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 LEU P  30
PHE P  26
SER P 130
VAL P 129
GLY P 118
 None
 1.04A 5f9zB-4dvyP:
undetectable		 5f9zB-4dvyP:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		3 / 3 ILE P 449
ILE P 463
MET P 405
 None
 0.64A 5i9yA-4dvyP:
undetectable		 5i9yA-4dvyP:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 7 SER P 142
PHE P 125
VAL P 129
ILE P  35
 None
 1.19A 5vkqA-4dvyP:
3.2
5vkqB-4dvyP:
3.2		 5vkqA-4dvyP:
19.83
5vkqB-4dvyP:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 7 SER P 142
PHE P 125
VAL P 129
ILE P  35
 None
 1.19A 5vkqC-4dvyP:
2.9
5vkqD-4dvyP:
3.2		 5vkqC-4dvyP:
19.83
5vkqD-4dvyP:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 ALA P 567
GLU P 659
LEU P 663
ILE P 664
ASP P 658
 None
 1.25A 5vlmG-4dvyP:
undetectable		 5vlmG-4dvyP:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 12 LEU P 462
GLU P 602
ALA P 603
THR P 606
LEU P 475
 None
 1.08A 6f6iA-4dvyP:
undetectable
6f6iB-4dvyP:
0.9		 6f6iA-4dvyP:
7.35
6f6iB-4dvyP:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4dvy CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 5 LEU P  30
GLN P  31
PHE P  34
PHE P 219
 None
 1.00A 6nmpP-4dvyP:
4.0
6nmpW-4dvyP:
undetectable		 6nmpP-4dvyP:
13.39
6nmpW-4dvyP:
5.03