SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dvz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 7 ASP A 403
PHE A 426
ASN A 400
SER A 605
 None
 1.39A 1rqpB-4dvzA:
undetectable		 1rqpB-4dvzA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 7 ASP A 403
PHE A 426
ASN A 400
SER A 605
 None
 1.36A 2v7uB-4dvzA:
undetectable		 2v7uB-4dvzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		3 / 3 SER A 689
ASP A 787
ASN A 791
 None
 0.79A 3lsfB-4dvzA:
undetectable
3lsfE-4dvzA:
undetectable		 3lsfB-4dvzA:
20.25
3lsfE-4dvzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		3 / 3 ASP A 787
ASN A 791
SER A 689
 None
 0.81A 3lsfB-4dvzA:
undetectable
3lsfE-4dvzA:
undetectable		 3lsfB-4dvzA:
20.25
3lsfE-4dvzA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 6 ILE A 664
PHE A 543
ALA A 668
ASN A 586
 None
 0.74A 3pgyA-4dvzA:
undetectable
3pgyB-4dvzA:
undetectable		 3pgyA-4dvzA:
23.58
3pgyB-4dvzA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		3 / 3 ASP A 814
LEU A 815
PHE A 818
 None
 0.44A 4pthA-4dvzA:
undetectable		 4pthA-4dvzA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		5 / 11 LEU A 418
LEU A 415
GLU A 406
ALA A 409
LEU A 408
 None
 1.00A 4wg0F-4dvzA:
undetectable
4wg0G-4dvzA:
undetectable
4wg0H-4dvzA:
undetectable		 4wg0F-4dvzA:
2.73
4wg0G-4dvzA:
2.73
4wg0H-4dvzA:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		4 / 7 ASN A 544
LYS A 499
TYR A 473
LEU A 494
 None
 1.20A 4yv5B-4dvzA:
undetectable		 4yv5B-4dvzA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 4dvz CYTOTOXICITY-ASSOCIA
TED IMMUNODOMINANT
ANTIGEN
(Helicobacter
pylori) 		3 / 3 ILE A 449
ILE A 463
MET A 405
 None
 0.67A 5i9yA-4dvzA:
undetectable		 5i9yA-4dvzA:
19.72