SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dwd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		3 / 3 ASP A 327
THR A 300
GLU A 249
 None
 0.80A 1pj7A-4dwdA:
undetectable		 1pj7A-4dwdA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 11 GLY A 232
ASN A 200
SER A 203
VAL A 204
ALA A 207
 CL  A 503 (-3.5A)
None
None
None
None
 0.95A 3dcmX-4dwdA:
2.1		 3dcmX-4dwdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 9 ASP A  34
GLY A  35
ALA A  32
ILE A   5
LEU A   3
 None
 1.00A 3ogpA-4dwdA:
undetectable		 3ogpA-4dwdA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_1
(PROLINE--TRNA LIGASE)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		3 / 3 GLU A 223
THR A 300
HIS A 298
 None
 0.85A 4q15A-4dwdA:
undetectable		 4q15A-4dwdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		4 / 8 LEU A 214
ASP A 177
ALA A 181
VAL A 184
 None
 0.86A 4zbqA-4dwdA:
1.0		 4zbqA-4dwdA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 12 GLY A  38
LEU A 109
ILE A 100
ILE A 357
GLY A 111
 None
 0.94A 5d4uC-4dwdA:
undetectable		 5d4uC-4dwdA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 12 GLY A  38
LEU A 109
ILE A 100
ILE A 357
GLY A 111
 None
 1.01A 5d4uD-4dwdA:
undetectable		 5d4uD-4dwdA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		4 / 6 CYH A  98
LEU A  63
HIS A  71
LEU A  75
 None
 0.86A 5hpuC-4dwdA:
undetectable
5hpuD-4dwdA:
undetectable		 5hpuC-4dwdA:
4.85
5hpuD-4dwdA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		4 / 5 TYR A 252
LYS A 274
GLU A 249
GLY A 248
 None
None
None
CL  A 502 (-3.5A)
 1.49A 5jhdJ-4dwdA:
undetectable		 5jhdJ-4dwdA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		3 / 3 ARG A 337
ILE A 357
PHE A 336
 None
 0.72A 5kirA-4dwdA:
undetectable		 5kirA-4dwdA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		4 / 8 GLY A 303
ALA A 308
PHE A 336
PHE A  27
 None
 0.96A 5mvsB-4dwdA:
undetectable		 5mvsB-4dwdA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 12 ARG A 240
PHE A 222
ALA A 207
VAL A 204
SER A 203
 None
 1.07A 6c2mC-4dwdA:
undetectable		 6c2mC-4dwdA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN
(Paracoccus
denitrificans) 		5 / 10 VAL A 312
LEU A 316
PHE A 295
GLY A 280
GLY A 305
 None
 1.18A 6eu9B-4dwdA:
undetectable		 6eu9B-4dwdA:
11.81