SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4dwq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.02A 1cqeA-4dwqA:
undetectable		 1cqeA-4dwqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.02A 1cqeB-4dwqA:
undetectable		 1cqeB-4dwqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 8 SER A  88
SER A 270
ILE A 256
GLY A  85
 None
 0.56A 1me7A-4dwqA:
undetectable		 1me7A-4dwqA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 8 SER A  88
SER A 270
ILE A 256
GLY A  85
 None
 0.67A 1meiA-4dwqA:
undetectable		 1meiA-4dwqA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		3 / 3 GLU A 253
TRP A 263
LYS A 413
 None
 1.12A 1qu2A-4dwqA:
undetectable		 1qu2A-4dwqA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		6 / 10 LEU A 148
ALA A 192
ILE A 137
GLY A 135
GLY A 196
ILE A 144
 None
 1.45A 1sdvA-4dwqA:
undetectable		 1sdvA-4dwqA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 10 LEU A 148
GLY A 191
ALA A 192
ILE A 137
GLY A 196
 None
 1.02A 1t7iA-4dwqA:
undetectable		 1t7iA-4dwqA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 0.93A 2aylA-4dwqA:
undetectable		 2aylA-4dwqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.03A 2aylB-4dwqA:
undetectable		 2aylB-4dwqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 11 ALA A 284
ALA A 192
GLY A 191
ALA A 187
ASP A 247
 None
None
None
None
PO4  A 507 ( 4.9A)
 1.12A 2f16H-4dwqA:
undetectable
2f16I-4dwqA:
undetectable		 2f16H-4dwqA:
19.46
2f16I-4dwqA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 11 ALA A 284
ALA A 192
GLY A 191
ALA A 187
ASP A 247
 None
None
None
None
PO4  A 507 ( 4.9A)
 1.14A 2f16V-4dwqA:
undetectable
2f16W-4dwqA:
undetectable		 2f16V-4dwqA:
19.46
2f16W-4dwqA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 LEU A 148
GLY A 191
ALA A 192
ILE A 137
GLY A 196
 None
 0.91A 2hs1B-4dwqA:
undetectable		 2hs1B-4dwqA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		6 / 12 LEU A 268
GLY A  91
ILE A  61
GLY A  75
ILE A  74
VAL A  50
 None
None
None
None
POP  A 509 ( 4.6A)
None
 1.48A 2nnkB-4dwqA:
undetectable		 2nnkB-4dwqA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		6 / 12 LEU A 148
GLY A 191
ALA A 192
ILE A 137
GLY A 196
ILE A 144
 None
 1.25A 2qakA-4dwqA:
undetectable		 2qakA-4dwqA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 9 ILE A 256
PRO A 272
ILE A  87
PHE A  72
VAL A  28
 None
 1.16A 2ygpA-4dwqA:
undetectable		 2ygpA-4dwqA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 MET A 381
ALA A 450
THR A 383
PHE A 204
GLY A 407
 5GP  A 501 (-4.4A)
None
None
5GP  A 501 (-3.6A)
5GP  A 501 (-3.3A)
 1.31A 3aodC-4dwqA:
1.6		 3aodC-4dwqA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 TYR A 386
GLY A 449
ALA A 415
ASP A 455
VAL A 454
 None
 1.05A 3dmfA-4dwqA:
undetectable		 3dmfA-4dwqA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		6 / 10 LEU A 148
GLY A 191
ALA A 192
ILE A 137
GLY A 196
ILE A 144
 None
 1.29A 3ekpD-4dwqA:
undetectable		 3ekpD-4dwqA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 PHE A 311
VAL A 127
VAL A 112
LEU A 107
THR A 105
 None
 1.36A 3elzA-4dwqA:
0.4		 3elzA-4dwqA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 ASP A  65
LEU A   5
ARG A  27
PRO A  73
GLY A  76
 None
 1.02A 3j6pB-4dwqA:
undetectable		 3j6pB-4dwqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		3 / 3 ARG A 350
GLU A 171
TYR A 325
 None
 0.65A 3k37B-4dwqA:
undetectable		 3k37B-4dwqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 5 SER A 197
ARG A 238
GLY A 201
GLU A 445
 None
PO4  A 506 ( 4.3A)
None
None
 1.26A 3k9fA-4dwqA:
0.9
3k9fB-4dwqA:
0.9
3k9fC-4dwqA:
undetectable		 3k9fA-4dwqA:
22.78
3k9fB-4dwqA:
22.78
3k9fC-4dwqA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 11 ALA A 284
ALA A 192
GLY A 191
ALA A 187
ASP A 247
 None
None
None
None
PO4  A 507 ( 4.9A)
 1.08A 3mg0V-4dwqA:
undetectable
3mg0W-4dwqA:
undetectable		 3mg0V-4dwqA:
19.46
3mg0W-4dwqA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.05A 3n8wA-4dwqA:
undetectable		 3n8wA-4dwqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.02A 3n8zA-4dwqA:
undetectable		 3n8zA-4dwqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.02A 3n8zB-4dwqA:
undetectable		 3n8zB-4dwqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 0.99A 3nt1A-4dwqA:
undetectable		 3nt1A-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.00A 3nt1B-4dwqA:
undetectable		 3nt1B-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 LEU A 148
GLY A 191
ALA A 192
ILE A 137
GLY A 196
 None
 0.96A 3nu5B-4dwqA:
undetectable		 3nu5B-4dwqA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 10 LEU A 148
GLY A 191
ALA A 192
ILE A 137
GLY A 196
 None
 1.00A 3oxwC-4dwqA:
undetectable		 3oxwC-4dwqA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 LEU A 148
GLY A 191
ALA A 192
ILE A 137
GLY A 196
 None
 0.98A 3oxxC-4dwqA:
undetectable		 3oxxC-4dwqA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.08A 3pghA-4dwqA:
undetectable		 3pghA-4dwqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.08A 3pghD-4dwqA:
undetectable		 3pghD-4dwqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 8 VAL A 324
VAL A 210
MET A 473
TYR A 222
 None
 0.82A 3remA-4dwqA:
undetectable		 3remA-4dwqA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 8 VAL A 324
VAL A 210
MET A 473
TYR A 222
 None
 0.85A 3remB-4dwqA:
undetectable		 3remB-4dwqA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		3 / 3 PHE A  80
SER A 270
SER A  88
 None
 0.87A 3ufgB-4dwqA:
undetectable		 3ufgB-4dwqA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		3 / 3 ARG A 250
ASP A 265
GLN A  46
 None
 0.83A 4azsA-4dwqA:
undetectable		 4azsA-4dwqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 SER A 401
GLN A  46
THR A  43
ARG A 350
HIS A  67
 None
None
None
None
POP  A 509 (-3.7A)
 1.45A 4c49D-4dwqA:
undetectable		 4c49D-4dwqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 6 GLY A 372
VAL A 364
PRO A 358
GLY A 400
 None
 0.86A 4dxuA-4dwqA:
undetectable		 4dxuA-4dwqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 GLU A 171
GLU A 170
GLY A 173
ARG A 101
VAL A 348
 None
 1.35A 4ffwA-4dwqA:
undetectable		 4ffwA-4dwqA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 7 GLY A 372
VAL A 364
PRO A 358
GLY A 400
 None
 0.84A 4forA-4dwqA:
undetectable		 4forA-4dwqA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 6 GLU A 316
ARG A 304
ASP A 322
ARG A 168
 PO4  A 508 (-4.1A)
None
None
None
 1.34A 4kcnA-4dwqA:
undetectable		 4kcnA-4dwqA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOX_A_CLSA205_1
(UNCHARACTERIZED
PROTEIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 11 TYR A  94
GLY A  93
ASN A 330
TYR A 281
ARG A 190
 None
MLI  A 503 (-3.6A)
MLI  A 503 (-4.1A)
None
PO4  A 506 (-3.7A)
 1.45A 4koxA-4dwqA:
undetectable		 4koxA-4dwqA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.08A 4otyB-4dwqA:
undetectable		 4otyB-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.09A 4rrwA-4dwqA:
undetectable		 4rrwA-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.09A 4rrwB-4dwqA:
undetectable		 4rrwB-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.10A 4rrxA-4dwqA:
undetectable		 4rrxA-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.09A 4rrxB-4dwqA:
undetectable		 4rrxB-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.09A 4rrzA-4dwqA:
undetectable		 4rrzA-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.09A 4rrzB-4dwqA:
undetectable		 4rrzB-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 9 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.02A 4rs0A-4dwqA:
undetectable		 4rs0A-4dwqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 11 LEU A 240
PHE A 291
ALA A 288
THR A 235
ILE A 299
 None
 1.34A 4uuuA-4dwqA:
undetectable
4uuuB-4dwqA:
undetectable		 4uuuA-4dwqA:
15.56
4uuuB-4dwqA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 7 ALA A 394
THR A 391
VAL A 375
LYS A 468
 None
 1.11A 5ecnA-4dwqA:
undetectable		 5ecnA-4dwqA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 8 VAL A 147
LEU A 148
GLY A 191
ALA A 192
 None
 0.72A 5f1aA-4dwqA:
undetectable		 5f1aA-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 PRO A  73
GLY A  93
GLY A  91
ILE A 331
ASN A  97
 None
MLI  A 503 (-3.6A)
None
None
None
 1.08A 5fa8A-4dwqA:
undetectable		 5fa8A-4dwqA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 9 ILE A 476
PRO A 475
VAL A 303
LEU A 123
TYR A 434
 None
 1.37A 5iepA-4dwqA:
undetectable		 5iepA-4dwqA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 ILE A  92
ASN A 330
HIS A 349
ALA A 353
MET A 175
 None
MLI  A 503 (-4.1A)
None
None
None
 1.22A 5igyA-4dwqA:
undetectable		 5igyA-4dwqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.09A 5ikqA-4dwqA:
undetectable		 5ikqA-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.11A 5ikqB-4dwqA:
undetectable		 5ikqB-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 0.97A 5ikrA-4dwqA:
undetectable		 5ikrA-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.05A 5ikrB-4dwqA:
undetectable		 5ikrB-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.08A 5iktB-4dwqA:
undetectable		 5iktB-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.04A 5jvzA-4dwqA:
undetectable		 5jvzA-4dwqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.05A 5jvzB-4dwqA:
undetectable		 5jvzB-4dwqA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 4 ASN A 295
LEU A 195
SER A 237
LEU A 148
 None
 1.31A 5kb5A-4dwqA:
undetectable		 5kb5A-4dwqA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 VAL A 147
ALA A 284
GLY A 191
ALA A 192
LEU A 139
 None
 0.95A 5kirB-4dwqA:
undetectable		 5kirB-4dwqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 8 SER A 270
ILE A 256
LEU A  53
PRO A 272
 None
 1.08A 5u4sB-4dwqA:
undetectable		 5u4sB-4dwqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 4 LEU A 268
ASP A 265
GLN A  46
VAL A 334
 None
 1.36A 6bzoF-4dwqA:
0.8		 6bzoF-4dwqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 GLN A 194
GLY A 191
ILE A 299
GLY A 135
ALA A 294
 PO4  A 506 (-3.6A)
None
None
None
None
 1.17A 6c2mB-4dwqA:
undetectable		 6c2mB-4dwqA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 8 TYR A  59
VAL A 339
VAL A 348
VAL A 346
 None
MLI  A 504 ( 4.4A)
None
None
 1.08A 6cp4A-4dwqA:
undetectable		 6cp4A-4dwqA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 LEU A 148
GLY A 191
ALA A 192
ILE A 137
GLY A 196
 None
 1.02A 6dh3B-4dwqA:
undetectable		 6dh3B-4dwqA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 LEU A 148
GLY A 191
ALA A 192
ILE A 137
GLY A 196
 None
 1.05A 6dh6B-4dwqA:
undetectable		 6dh6B-4dwqA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_0
(ADENOSYLHOMOCYSTEINA
SE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		5 / 12 HIS A  67
GLN A  46
THR A  43
ASN A 330
HIS A 404
 POP  A 509 (-3.7A)
None
None
MLI  A 503 (-4.1A)
5GP  A 501 (-3.0A)
 1.49A 6exiC-4dwqA:
undetectable		 6exiC-4dwqA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 8 TYR A 248
VAL A 244
PRO A  89
ILE A  92
 PO4  A 507 ( 4.8A)
None
None
None
 0.95A 6hzpA-4dwqA:
undetectable		 6hzpA-4dwqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 8 ALA A 289
GLY A 151
ALA A 178
GLU A 176
 None
 0.74A 6mdqA-4dwqA:
undetectable		 6mdqA-4dwqA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4dwq TRNA-SPLICING LIGASE
RTCB
(Pyrococcus
horikoshii) 		4 / 7 ASP A 455
ARG A 472
TYR A 386
ASP A 211
 None
 1.27A 6mn5E-4dwqA:
undetectable		 6mn5E-4dwqA:
10.71